The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cholesterol and prostate cancer
Open accessAbstract
Summary Prostate cancer risk can be modified by environmental factors, however the molecular mechanisms affecting susceptibility to this disease are not well understood. As a result of a series of recently published studies, the steroidal lipid, cholesterol, has emerged as a clinically relevant therapeutic target in prostate cancer. This review summarizes the findings from human studies as well as animal and cell biology models which suggest that high circulating cholesterol increases risk of aggressive prostate cancer, while cholesterol lowering strategies may confer protective benefit. Relevant molecular processes that have been experimentally tested and might explain these associations are described. We suggest that these promising results now could be applied prospectively to attempt to lower risk of prostate cancer in select populations.
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Zhuang, L., Kim, J., Adam, R. M., Solomon, K. R., & Freeman, M. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200519935 · Cited by 567
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Metadata
- Authors
- Pelton, K., Freeman, M. R., & Solomon, K. R.
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 12
- Issue
- 6
- Pages
- 751-759
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2014393189
- Cited by
- 303
- References
- 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Pelton, K., Freeman, M. R., & Solomon, K. R. (2012). Cholesterol and prostate cancer. Current Opinion in Pharmacology. https://doi.org/10.1016/j.coph.2012.07.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
