Transient Receptor Potential Channels in neuropathic pain
Abstract
Neuropathic pain caused by disease or dysfunction of the nervous system is one of the most difficult pain conditions to treat. Symptoms include a hypersensitivity to mechanical and thermal stimuli, processed by specialized nociceptors that constitute the first line of defence of the somatosensory system. The detection of these stimuli depends on the TRP ion channel family, which activates upon damaging pressure, extreme temperature, or toxic endogenous and exogenous chemicals. This review will summarize the current knowledge of the contribution of TRP channels, particularly the thermosensitive TRP, including TRPV1, TRPA1 and TRPM8 channels that play a central role in the sensitization of nociceptive transduction. We will discuss the pharmacology of these receptors and their relative success in preclinical and clinical studies.
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The prolactin-PRLR axis contributes to activation of pain-related pathways through sensitization of transient receptor potential channels that promote painful sensations.
“The prolactin-PRLR axis contributes to the activation of pain-related pathways through the sensitization of transient receptor potential channels that promote painful sensations [157,158].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [158]
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References 62 · Cited by 134
- Authors
- Basso, L., & Altier, C.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Altier, Christophe
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 32
- Pages
- 9-15
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2541941721
- Cited by
- 134
- References
- 62
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 9 · 2023: 13 · 2022: 16 · 2021: 19 · 2020: 20 · 2019: 11 · 2018: 17 · 2017: 10
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (CIHR)
- Natural Sciences and Engineering Research Council (NSERC)
- Alberta Children's Hospital Research Institute (ACHRI)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- TRP channels, neuropathic pain, TRPV1, TRPA1, TRPM8, nociceptors, sensory sensitization, analgesic drug development
- MeSH terms
- TRPA1 Cation Channel, Analgesics, Animals, Humans, Nerve Tissue Proteins, Neuralgia, Temperature, Drug Design, Calcium Channels, Transient Receptor Potential Channels, TRPM Cation Channels, TRPV Cation Channels
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