Metabolic adaptations after bariatric surgery: Adipokines, myokines and hepatokines
Abstract
This review addresses the impact of bariatric surgery on the endocrine aspects of white adipose tissue, muscle and the liver. We describe literature supporting the notion that adipokines, myokines and hepatokines likely act in concert and drive many of the long-term metabolic improvements following surgery. Circulating adiponectin is increased while secretion of pro-inflammatory interleukins (1, 6 and 8) decreases, alongside leptin secretion. The metabolic improvements observed in the muscle might relate to reduction of myokines contributing to insulin resistance (including myostatin, brain-derived neurotrophic factor and fibroblast growth factor-21). Subject to exception, hepatokine secretion is generally increased (such as insulin-like growth factor-binding protein 2, adropin and sex hormone-binding globulin). In conclusion, bariatric surgery restores metabolic functions by enhancing the time-dependent secretion of anti-inflammatory, insulin-sensitizing and antilipemic factors. Further research is needed to understand the molecular mechanisms by which these factors may trigger the remission of obesity-related comorbidities following bariatric surgery.
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Organokines have specific associations with insulin resistance, diabetes mellitus, obesity, metabolic syndrome, and cardiovascular disease.
“Therefore, they have specific associations with insulin resistance, diabetes mellitus, obesity, metabolic syndrome, and CVD [10].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [10]
The network of adipokines, myokines, and hepatokines may have beneficial or non-beneficial effects on the genesis of various physiological disorders and their outcomes, such as DM2, obesity, metabolic syndrome, and CVD.
“Far beyond understanding each adipokine, myokine, or hepatokine’s actions alone, it is important to underline that these cytokines act together in the body, forming a complex network of actions in different tissues, which may have beneficial or non-beneficial effects on the genesis of various physiological disorders, and their respective outcomes, such as DM2, obesity, metabolic syndrome, and CVD”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [10]
Adipokines, myokines, and hepatokines act together in the body, forming a complex network of actions in different tissues.
“Far beyond understanding each adipokine, myokine, or hepatokine’s actions alone, it is important to underline that these cytokines act together in the body, forming a complex network of actions in different tissues, which may have beneficial or non-beneficial effects on the genesis of various physiological disorders, and their respective outcomes, such as DM2, obesity, metabolic syndrome, and CVD”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [10]
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References 89 · Cited by 44
- Authors
- Faramia, J., Ostinelli, G., Drolet-Labelle, V., Picard, F., & Tchernof, A.
- Affiliations
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Corresponding author
- Picard, Frédéric
- Tchernof, André
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 52
- Pages
- 67-74
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W3043222142
- Cited by
- 44
- References
- 89
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 7 · 2023: 6 · 2022: 9 · 2021: 4 · 2020: 3
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johnson & Johnson Medical Companies
- Medtronic
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- bariatric surgery, adipokines, myokines, hepatokines, white adipose tissue, skeletal muscle, liver, adiponectin, leptin, interleukins, myostatin, brain-derived neurotrophic factor, FGF21, insulin resistance, IGFBP-2, adropin, sex hormone-binding globulin, anti-inflammatory factors, insulin sensitivity
- MeSH terms
- Adaptation, Physiological, Adipose Tissue, Humans, Liver, Obesity, Muscle, Skeletal, Bariatric Surgery, Adipokines
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