The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Exercise intolerance in patients with mitochondrial myopathies: perfusive and diffusive limitations in the O2 pathway
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, these approaches primarily reflect the balance between oxygen delivery and extraction rather than measuring muscle oxidative capacity itself.”
From Effect of live‐high, train‐low strategy induced by chronic low‐dose carbon monoxide exposure on haematological parameters and performance in trained individuals (2026) · cites this paper as Porcelli et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Aerobic training is safe and improves exercise capacity in patients with mitochondrial myopathy
Jeppesen, T. D., Schwartz, M., Olsen, D. B., Wibrand, F., Krag, T., Duno, M., Hauerslev, S., & Vissing, J. (2006) · Brain · doi:10.1093/brain/awl149 · Cited by 211
Tarnopolsky, M. A. (2016) · Continuum · doi:10.1212/con.0000000000000403 · Cited by 61
Research works printed but not linked: 49
- Ahmed, 2018, Diagnosis and treatment of mitochondrial myopathies, Neurotherapeutics, 15, 943, 10.1007/s13311-018-00674-4 · DOI
- Bank, 1994, An oxidative defect in metabolic myopathies: diagnosis by noninvasive tissue oximetry, Ann Neurol, 36, 830, 10.1002/ana.410360606 · DOI
- Bowen, 2013, Slowed oxygen uptake kinetics in hypoxia correlate with the transient peak and reduced spatial distribution of absolute skeletal muscle deoxygenation, Exp Physiol, 98, 1585, 10.1113/expphysiol.2013.073270 · DOI
- Cejudo, 2005, Exercise training in mitochondrial myopathy: a randomized controlled trial, Muscle Nerve, 32, 342, 10.1002/mus.20368 · DOI
- Delaney, 2017, Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy, Proc Natl Acad Sci U S A, 114, 8402, 10.1073/pnas.1703338114 · DOI
- di Prampero, 2003, Factors limiting maximal performance in humans, Eur J Appl Physiol, 90, 420, 10.1007/s00421-003-0926-z · DOI · Paper page
- Federspiel, 1986, A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries, Microvasc Res, 32, 164, 10.1016/0026-2862(86)90052-X · DOI
- Filosto, 2019, Muscle pain in mitochondrial diseases: a picture from the Italian network, J Neurol, 266, 953, 10.1007/s00415-019-09219-x · DOI
- Fiuza-Luces, 2018, Health benefits of an innovative exercise program for mitochondrial disorders, Med Sci Sports Exerc, 50, 1142, 10.1249/MSS.0000000000001546 · DOI
- Grassi, 2007, Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy, Muscle Nerve, 35, 510, 10.1002/mus.20708 · DOI
- Grassi, 2009, Metabolic myopathies: functional evaluation by analysis of oxygen uptake kinetics, Med Sci Sports Exerc, 41, 2120, 10.1249/MSS.0b013e3181aae96b · DOI · Paper page
- Grassi, 2019, Translational medicine: exercise physiology applied to metabolic myopathies, Med Sci Sports Exerc, 10.1249/MSS.0000000000002056 · DOI
- Groebe, 1990, Calculated intra- and extracellular PO2 gradients in heavily working red muscle, Am J Physiol, 259, H84
- Heinicke, 2011, Exertional dyspnea in mitochondrial myopathy: clinical features and physiological mechanisms, Am J Physiol Regul Integr Comp Physiol, 301, R873, 10.1152/ajpregu.00001.2011 · DOI
- Hepple, 2000, Structural basis of muscle O2 diffusing capacity: evidence from muscle function in situ, J Appl Physiol, 88, 560, 10.1152/jappl.2000.88.2.560 · DOI
- Hirai, 2015, Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization, Am J Physiol Heart Circ Physiol, 309, H1419, 10.1152/ajpheart.00469.2015 · DOI
- Hogan, 1992, Role of O2 in regulating tissue respiration in dog muscle working in situ, J Appl Physiol, 73, 728, 10.1152/jappl.1992.73.2.728 · DOI
- Jeppesen, 2006, Muscle phenotype and mutation load in 51 persons with the 3243A > G mitochondrial DNA mutation, Arch Neurol, 63, 1701, 10.1001/archneur.63.12.1701 · DOI
- Jeppesen, 2012, Influence of erythrocyte oxygenation and intravascular ATP on resting and exercising skeletal muscle blood flow in humans with mitochondrial myopathy, Mitochondrion, 12, 414, 10.1016/j.mito.2011.11.003 · DOI
- Kanabus, 2014, Development of pharmacological strategies for mitochondrial disorders, Br J Pharmacol, 171, 1798, 10.1111/bph.12456 · DOI
- Karaa, 2018, Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy, Neurology, 90, e1212, 10.1212/WNL.0000000000005255 · DOI
- Koo, 2018, Metabolic myopathies and the respiratory system, Clin Chest Med, 39, 401, 10.1016/j.ccm.2018.02.001 · DOI
- Korzeniewski, 2015, Each-step activation of oxidative phosphorylation is necessary to explain muscle metabolic kinetic responses to exercise and recovery in humans, J Physiol, 5255, 10.1113/JP271299 · DOI
- Lilleker, 2018, Metabolic myopathies: a practical approach, Pract Neurol, 18, 14, 10.1136/practneurol-2017-001708 · DOI
- Linderholm, 1969, Hereditary abnormal muscle metabolism with hyperkinetic circulation during exercise, Acta Med Scand, 185, 153, 10.1111/j.0954-6820.1969.tb07314.x · DOI
- Marzorati, 2012, Exercise testing in late-onset glycogen storage disease type II patients undergoing enzyme replacement therapy, Neuromuscul Disord, 22, S230, 10.1016/j.nmd.2012.10.017 · DOI
- Murphy, 2008, Resistance training in patients with single, large-scale deletions of mitochondrial DNA, Brain, 131, 2832, 10.1093/brain/awn252 · DOI
- Nabben, 2017, Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy, Am J Physiol Regul Integr Comp Physiol, 312, R689, 10.1152/ajpregu.00264.2016 · DOI
- Padilla, 2007, Effects of Type II diabetes on muscle microvascular oxygen pressures, Respir Physiol Neurobiol, 156, 187, 10.1016/j.resp.2006.08.008 · DOI
- Poole, 2006, Capillary hemodynamics and oxygen pressures in the aging microcirculation, Microcirculation, 13, 289, 10.1080/10739680600618793 · DOI
- Poole, 2012, Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance, Am J Physiol Heart Circ Physiol, 302, H1050, 10.1152/ajpheart.00943.2011 · DOI
- Porcelli, 2010, Role of skeletal muscles impairment and brain oxygenation in limiting oxidative metabolism during exercise after bed rest, J Appl Physiol, 109, 101, 10.1152/japplphysiol.00782.2009 · DOI
- Porcelli, 2014, The “second wind” in McArdle’s disease patients during a second bout of constant work rate submaximal exercise, J Appl Physiol, 116, 1230, 10.1152/japplphysiol.01063.2013 · DOI
- Porcelli, 2016, Home-based aerobic exercise training improves skeletal muscle oxidative metabolism in patients with metabolic myopathies, J Appl Physiol, 121, 699, 10.1152/japplphysiol.00885.2015 · DOI
- Riley, 2017, Cardiopulmonary exercise testing and metabolic myopathies, Ann Am Thorac Soc, 14, S129, 10.1513/AnnalsATS.201701-014FR · DOI
- Roca, 1992, Effects of training on muscle O2 transport at V˙O2 max, J Appl Physiol, 73, 1067, 10.1152/jappl.1992.73.3.1067 · DOI
- Salvadego, 2016, Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans, J Appl Physiol, 121, 154, 10.1152/japplphysiol.00832.2015 · DOI
- Salvadego, 2018, PlanHab*: hypoxia does not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone, J Physiol, 596, 3341, 10.1113/JP275605 · DOI
- Samaja, 1981, Equations and nomogram for the relationship of human blood p50 to 2,3-diphosphoglycerate, CO2, and H+, Clin Chem, 27, 1856, 10.1093/clinchem/27.11.1856 · DOI
- Sperandio, 2012, Sildenafil improves microvascular O2 delivery-to-utilization matching and accelerates exercise O2 uptake kinetics in chronic heart failure, Am J Physiol Heart Circ Physiol, 303, H1474, 10.1152/ajpheart.00435.2012 · DOI
- Taivassalo, 2001, Aerobic conditioning in patients with mitochondrial myopathies: physiological, biochemical, and genetic effects, Ann Neurol, 50, 133, 10.1002/ana.1050 · DOI
- Taivassalo, 2002, Venous oxygen levels during aerobic forearm exercise: an index of impaired oxidative metabolism in mitochondrial myopathy, Ann Neurol, 51, 38, 10.1002/ana.10027 · DOI
- Taivassalo, 2003, The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients, Brain, 126, 413, 10.1093/brain/awg028 · DOI · Paper page
- Taivassalo, 2006, Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions, Brain, 129, 3391, 10.1093/brain/awl282 · DOI · Paper page
- Taivassalo, 2012, Increased capillaries in mitochondrial myopathy: implications for the regulation of oxygen delivery, Brain, 135, 53, 10.1093/brain/awr293 · DOI
- Trenell, 2007, Supplemental oxygen and muscle metabolism in mitochondrial myopathy patients, Eur J Appl Physiol, 99, 541, 10.1007/s00421-006-0372-9 · DOI
- Toscano, 2017, Update on diagnostics of metabolic myopathies, Curr Opin Neurol, 30, 553, 10.1097/WCO.0000000000000483 · DOI
- Wagner, 2011, Modeling O2 transport as an integrated system limiting V˙O2 max), Comput Methods Programs Biomed, 101, 109, 10.1016/j.cmpb.2010.03.013 · DOI
- Viscomi, 2015, Emerging concepts in the therapy of mitochondrial disease, Biochim Biophys Acta, 1847, 544, 10.1016/j.bbabio.2015.03.001 · DOI
Cited by
Guidelines for animal exercise and training protocols for cardiovascular studies
Poole, D. C., Copp, S. W., Colburn, T. D., Craig, J. C., Allen, D. L., Sturek, M., O’Leary, D. S., Zucker, I. H., & Musch, T. I. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00697.2019 · Cited by 139
Self-citationVillanova, S., Porcelli, S., Ekström, L., & Cardinale, D. A. (2026) · Experimental Physiology · doi:10.1113/ep093005 · Cited by 5
Self-citation
Metadata
- Authors
- Porcelli, S., Grassi, B., Poole, D. C., & Marzorati, M.
- Venue
- Current Opinion in Physiology
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 10
- Pages
- 202-209
- ISSN
- 2468-8673
- Cited by
- 13
- References
- 2
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Exercise intolerance in patients with mitochondrial myopathies: perfusive and diffusive limitations in the O2 pathway. https://app.cochat.ai/papers/10.1016/j.cophys.2019.05.011
- The paper
- Porcelli, S., Grassi, B., Poole, D. C., & Marzorati, M. (2019). Exercise intolerance in patients with mitochondrial myopathies: perfusive and diffusive limitations in the O2 pathway. Current Opinion in Physiology. https://doi.org/10.1016/j.cophys.2019.05.011
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.