Insomnia and depression: clinical associations and possible mechanistic links
Abstract
Chronic insomnia is highly comorbid with multiple psychological and physical disorders, but most notably depression. While insomnia is now viewed as a risk factor for depression, and not just a 'symptom' of the disorder, the reasons for this change in classification (from symptom to risk factor) have yet to be clearly articulated. This is one goal of the present review. Furthermore, efforts to identify the mechanisms, by which insomnia is related to increases in depression is a burgeoning area of research. Here, our second goal is to highlight several potential mechanisms that can be targets for future research.
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The strong association of depressive and insomnia symptoms is consistent with evidence supporting their high level of comorbidity.
“The strong association of depressive and insomnia symptoms is consistent with evidence supporting their high level of comorbidity [35, 62–65].”
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References 64 · Cited by 95
- Authors
- Vargas, I., & Perlis, M. L.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Perlis, Michael L
- Venue
- Current Opinion in Psychology
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 34
- Pages
- 95-99
- ISSN
- 2352-250X (ISSN-L)
- OpenAlex
- W2993008853
- Cited by
- 95
- References
- 64
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 19 · 2023: 19 · 2022: 10 · 2021: 13 · 2020: 6
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32HL007953)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- chronic insomnia, depression, pathophysiological mechanisms, sleep disorders, psychiatric comorbidity
- MeSH terms
- Depression, Humans, Sleep Initiation and Maintenance Disorders, Motivation, Risk Factors
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