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Cited by 25Neural and Behavioral Psychology StudiesParkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatments

Normal aging and Parkinson's disease are associated with the functional decline of distinct frontal-striatal circuits

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Gruszka, Aleksandra, Hampshire, Adam, Barker, Roger A., Owen, Adrian M.·2017·Cortex
DOI 10.1016/j.cortex.2017.05.020PMC PMC5542042
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Abstract

Impaired ability to shift attention between stimuli (i.e. shifting attentional 'set') is a well-established part of the dysexecutive syndrome in Parkinson's Disease (PD), nevertheless cognitive and neural bases of this deficit remain unclear. In this study, an fMRI-optimised variant of a classic paradigm for assessing attentional control (Hampshire and Owen 2006) was used to contrast activity in dissociable executive circuits in early-stage PD patients and controls. The results demonstrated that the neural basis of the executive performance impairments in PD is accompanied by hypoactivation within the striatum, anterior cingulate cortex (vACC), and inferior frontal sulcus (IFS) regions. By contrast, in aging it is associated with hypoactivation of the anterior insula/inferior frontal operculum (AI/FO) and the pre-supplementary motor area (preSMA). Between group behavioural differences were also observed; whereas normally aging individuals exhibited routine-problem solving deficits, PD patients demonstrated more global task learning deficits. These findings concur with recent research demonstrating model-based reinforcement learning deficits in PD and provide evidence that the AI/FO and IFS circuits are differentially impacted by PD and normal aging.

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  • Deficits in flexible updating are consistently linked to fronto-striatal dysfunction in patients.

    “and are consistently linked to fronto-striatal dysfunction in patients [17, 28, 31–33].”

    From Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility (2024) · cites this paper as [32]

    The Discussion (‘The neural basis of set-shifting deficits in PD’; page not provided) links attentional set-shifting impairments in Parkinson’s disease to reduced activity in frontal regions and the caudate nucleus. That supports a link between a form of cognitive flexibility and fronto-striatal dysfunction, but the paper does not establish the broader claim about flexible updating consistently across patients. (LLM, conf=0.83)

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Authors
Gruszka, A., Hampshire, A., Barker, R. A., & Owen, A. M.
Affiliations
  • Jagiellonian University (PL)
  • Imperial College London (GB)
  • University of Cambridge (GB)
  • Western University (CA)
Corresponding author
Gruszka, Aleksandra
ORCID
Venue
Cortex
Publisher
Elsevier BV
Published
2017-08
Volume
93
Pages
178-192
ISSN
0010-9452 (ISSN-L)
DOI
10.1016/j.cortex.2017.05.020
PMC
PMC5542042
OpenAlex
W2620571758
Cited by
25
References
84
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 2
FWCI
1.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Cortex (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Jagiellonian University Repository (Jagiellonian University) (submittedVersion, other-oa)
  • Scholarship@Western (Western University) (submittedVersion)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Apollo (cc-by)
Funders
Wellcome Trust (WT072378MA)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Parkinson's disease, normal aging, executive function, set-shifting, frontostriatal circuits, anterior insula, inferior frontal sulcus, anterior cingulate cortex, pre-supplementary motor area, model-based reinforcement learning
MeSH terms
Adult, Aged, Aging, Attention, Cognition Disorders, Female, Frontal Lobe, Humans, Learning, Male, Middle Aged, Parkinson Disease, Neostriatum

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