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Cited by 84HIV Research and TreatmentHIV/AIDS drug development and treatmentT-cell and Retrovirus Studies

Maturation of retroviruses

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Pornillos, Owen, Ganser-Pornillos, Barbie K·2019·Current Opinion in Virology
DOI 10.1016/j.coviro.2019.05.004PMC PMC6730672
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Abstract

During retrovirus maturation, cleavage of the precursor structural Gag polyprotein by the viral protease induces architectural rearrangement of the virus particle from an immature into a mature, infectious form. The structural rearrangement encapsidates the viral RNA genome in a fullerene capsid, producing a diffusible viral core that can initiate infection upon entry into the cytoplasm of a host cell. Maturation is an important therapeutic window against HIV-1. In this review, we highlight recent breakthroughs in understanding of the structures of retroviral immature and mature capsid lattices that define the boundary conditions of maturation and provide novel insights on capsid transformation. We also discuss emerging insights on encapsidation of the viral genome in the mature capsid, as well as remaining questions for further study.

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  • The core in mature retroviruses encases the viral RNA genome along with essential enzymes, such as RT and IN, ensuring that the virus is primed for infection.

    “The core in mature retroviruses encases the viral RNA genome along with essential enzymes, such as RT and IN, ensuring that the virus is primed for infection”

    From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Pornillos and Ganser-Pornillos 2019

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Cited by

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Authors
Pornillos, O., & Ganser-Pornillos, B. K.
Affiliations
University of Virginia (US)
Corresponding author
Pornillos, Owen
ORCID
Pornillos, Owen
Venue
Current Opinion in Virology
Publisher
Elsevier BV
Published
2019-06
Volume
36
Pages
47-55
ISSN
1879-6257 (ISSN-L)
DOI
10.1016/j.coviro.2019.05.004
PMC
PMC6730672
OpenAlex
W2955761623
Cited by
84
References
11
Citations by year
2026: 8 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 26 · 2020: 10 · 2019: 2
FWCI
2.03
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Virology (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords
HIV-1, Gag protein, viral protease, capsid lattice, viral RNA encapsidation, viral core, antiviral therapy
MeSH terms
Capsid, Models, Molecular, Peptide Hydrolases, Retroviridae, RNA, Viral, Virion, HIV-1, Genome, Viral, Virus Assembly, Capsid Proteins

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