The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The pattern and outcome of acute severe colitis
Abstract
BACKGROUND: The prognosis of acute severe ulcerative colitis (ASC) influences therapeutic decisions, but data on prevalence or long-term outcome are few. METHODS: A systematic review of all patients with UC diagnosed in Oxford was performed to assess the prevalence of ASC defined by Truelove and Witts' (TW) criteria and determine whether outcome is related to disease activity on admission, likelihood of recurrence and long-term prognosis. RESULTS: 750 patients (median follow up 12.7 yr, range 0-648 mo) met inclusion criteria out of a total cohort of 1853 patients. 24.8% (186/750) had at least one admission for ASC (294 admissions in 186 patients). Overall, 12% (93/750) had a colectomy, compared to 39.8% (74/186) of patients with one or more episodes of ASC (p<0.0001) and 3.4% (19/564) in those with no admission. The colectomy rate on first admission (37/186, 19.9%) was lower than on the second or subsequent admissions (OR 2.35, 95% CI 1.33-4.14, p=0.003), being 29.0%, 36.6%, 38.2% after two, three, or subsequent episodes respectively. It was 8.5% (11/129) if patients had one TW criterion in addition to ≥6 bloody bowel motions/day, compared to 31% (29/94) if two additional criteria were present and 48% (34/71) if three or more additional criteria were present (p=1.4 × 10⁻⁵; OR 4.35, 95% CI 2.20-8.56 one criterion vs two or more). CONCLUSIONS: A quarter of all patients with ulcerative colitis experience at least one episode of ASC; 20% come to colectomy on first admission, but 40% after two admissions. The likelihood of colectomy is related to biological severity on admission.
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Satsangi, J., Silverberg, M. S., Vermeire, S., & Colombel, J.-F. (2006) · Gut · doi:10.1136/gut.2005.082909 · Cited by 3,176
Kornbluth, A., & Sachar, D. B. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.727 · Cited by 2,023
The course and prognosis of ulcerative colitis: Part I Short-term prognosis
Edwards, F. C., & Truelove, S. C. (1963) · Gut · doi:10.1136/gut.4.4.299 · Cited by 854
Turner, D., Walsh, C. M., Steinhart, A. H., & Griffiths, A. M. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.09.033 · Cited by 659
Thirty-Year Analysis of a Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis
Rutter, M. D., Saunders, B. P., Wilkinson, K. H., Rumbles, S., Schofield, G., Kamm, M. A., Williams, C. B., Price, A. B., Talbot, I. C., & Forbes, A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.12.035 · Cited by 650
Stange, E. F., Travis, S. P. L., Vermeire, S., Reinisch, W., Geboes, K., Barakauskiene, A., Feakins, R., Fléjou, J. F., Herfarth, H., Hommes, D. W., et al. (2008) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2007.11.001 · Cited by 555
Self-citationKaplan, G. G., McCarthy, E. P., Ayanian, J. Z., Korzenik, J., Hodin, R., & Sands, B. E. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.004 · Cited by 301
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Low Colectomy Rates in Ulcerative Colitis in an Unselected European Cohort Followed for 10 Years
Hoie, O., Wolters, F. L., Riis, L., Bernklev, T., Aamodt, G., Clofent, J., Tsianos, E., Beltrami, M., Odes, S., Munkholm, P., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.015 · Cited by 272
Ciclosporin use in acute ulcerative colitis: a long-term experience
Campbell, S., Travis, S., & Jewell, D. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200501000-00016 · Cited by 206
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Cited by
Lamb, C. A., Kennedy, N. A., Raine, T., Hendy, P. A., Smith, P. J., Limdi, J. K., Hayee, B., Lomer, M. C. E., Parkes, G. C., Selinger, C., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318484 · Cited by 2,346
Ordás, I., Eckmann, L., Talamini, M., Baumgart, D. C., & Sandborn, W. J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60150-0 · Cited by 2,078
Le Berre, C., Honap, S., & Peyrin-Biroulet, L. (2023) · The Lancet · doi:10.1016/s0140-6736(23)00966-2 · Cited by 1,643
Dignass, A., Lindsay, J. O., Sturm, A., Windsor, A., Colombel, J.-F., Allez, M., D'Haens, G., D'Hoore, A., Mantzaris, G., Novacek, G., et al. (2012) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2012.09.002 · Cited by 1,548
Self-citationThe burden of inflammatory bowel disease in Europe
Burisch, J., Jess, T., Martinato, M., & Lakatos, P. L. (2013) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2013.01.010 · Cited by 961
Metadata
- Authors
- Dinesen, L. C., Walsh, A. J., Protic, M. N., Heap, G., Cummings, F., Warren, B. F., George, B., Mortensen, N. J. M., & Travis, S. P. L.
- Venue
- Journal of Crohn's and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-10
- Volume
- 4
- Issue
- 4
- Pages
- 431-437
- ISSN
- 1873-9946 (ISSN-L)
- OpenAlex
- W2085161424
- Cited by
- 403
- References
- 16
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- closed
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