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Case Report: Fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn's Disease
Abstract
We present the case of a 28 year old lady with refractory Crohn's Disease treated with infliximab throughout her pregnancy. Her baby was born healthy and received a Bacillus Calmette-Guérin (BCG) vaccine aged 3 months. Soon after this the infant became unwell and died aged 4.5 months. At post-mortem the cause of death was attributed to an unusual complication of the BCG vaccine, known as disseminated BCG. BCG vaccination is contraindicated in individuals who are receiving immunosuppressive drugs. We recommend physicians should exercise caution before such vaccines are used in infants born to mothers taking anti-TNF therapies or other potentially immunosuppressive IgG1 antibodies.
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Cited by
Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection
Julsgaard, M., Christensen, L. A., Gibson, P. R., Gearry, R. B., Fallingborg, J., Hvas, C. L., Bibby, B. M., Uldbjerg, N., Connell, W. R., Rosella, O., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.04.002 · Cited by 328
Psoriasis: Which therapy for which patient
Kaushik, S. B., & Lebwohl, M. G. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.06.056 · Cited by 268
Safety of dermatologic medications in pregnancy and lactation
Murase, J. E., Heller, M. M., & Butler, D. C. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.09.010 · Cited by 220
Metadata
- Authors
- Cheent, K., Nolan, J., Shariq, S., Kiho, L., Pal, A., & Arnold, J.
- Venue
- Journal of Crohn's and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11
- Volume
- 4
- Issue
- 5
- Pages
- 603-605
- ISSN
- 1873-9946 (ISSN-L)
- OpenAlex
- W2063459020
- Cited by
- 407
- References
- 0
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Case Report: Fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn's Disease. https://app.cochat.ai/papers/10.1016/j.crohns.2010.05.001
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- Cheent, K., Nolan, J., Shariq, S., Kiho, L., Pal, A., & Arnold, J. (2010). Case Report: Fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn's Disease. Journal of Crohn's and Colitis. https://doi.org/10.1016/j.crohns.2010.05.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
