The DOI matches its Crossref record; 146 of the 152 references it cites were found in a registry or an index.
Mechanisms of cryoablation: Clinical consequences on malignant tumors
Open accessAbstract
While the destructive actions of a cryoablative freeze cycle are long recognized, more recent evidence has revealed a complex set of molecular responses that provides a path for optimization. The importance of optimization relates to the observation that the cryosurgical treatment of tumors yields success only equivalent to alternative therapies. This is also true of all existing therapies of cancer, which while applied with curative intent; provide only disease suppression for periods ranging from months to years. Recent research has led to an important new understanding of the nature of cancer, which has implications for primary therapies, including cryosurgical treatment. We now recognize that a cancer is a highly organized tissue dependent on other supporting cells for its establishment, growth and invasion. Further, cancer stem cells are now recognized as an origin of disease and prove resistant to many treatment modalities. Growth is dependent on endothelial cells essential to blood vessel formation, fibroblasts production of growth factors, and protective functions of cells of the immune system. This review discusses the biology of cancer, which has profound implications for the diverse therapies of the disease, including cryosurgery. We also describe the cryosurgical treatment of diverse cancers, citing results, types of adjunctive therapy intended to improve clinical outcomes, and comment briefly on other energy-based ablative therapies. With an expanded view of tumor complexity we identify those elements key to effective cryoablation and strategies designed to optimize cancer cell mortality with a consideration of the now recognized hallmarks of cancer.
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“Despite these theoretical advantages, clinical response to cryoablation is highly variable and suffers from the absence of a reliable biomarker that predicts a beneficial therapeutic outcome of this approach.15”
From Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation (2023) · cites this paper as [15]
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Bonnet, D. A., & Dick, J. E. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,197
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632
Thermal dose determination in cancer therapy
Sapareto, S. A., & Dewey, W. C. (1984) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(84)90379-1 · Cited by 2,505
Mechanisms of Tissue Injury in Cryosurgery
Gage, A. A., & Baust, J. G. (1998) · Cryobiology · doi:10.1006/cryo.1998.2115 · Cited by 1,096
Self-citationHepatocellular Carcinoma: Radio-frequency Ablation of Medium and Large Lesions
Livraghi, T., Goldberg, S. N., Lazzaroni, S., Meloni, M. F., Ierace, T., Solbiati, L., & Gazelle, G. S. (2000) · Radiology · doi:10.1148/radiology.214.3.r00mr02761 · Cited by 1,011
Duration of Androgen Suppression in the Treatment of Prostate Cancer
Bolla, M., de Reijke, T. M., van Tienhoven, G., van den Bergh, A. C. M., Oddens, J. R., Poortmans, P. M., Gez, E., Kil, P. J. M., Akdaş, A., Soete, G., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810095 · Cited by 970
Guidelines for the management of basal cell carcinoma
Telfer, N. R., Colver, G. B., & Morton, C. A. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08666.x · Cited by 960
Sun, Y., Campisi, J., Higano, C., Beer, T. M., Porter, P., Coleman, I., True, L., & Nelson, P. S. (2012) · Nature Medicine · doi:10.1038/nm.2890 · Cited by 793
The cryobiology of cryosurgical injury
Hoffmann, N. E., & Bischof, J. C. (2002) · Urology · doi:10.1016/s0090-4295(02)01683-7 · Cited by 593
Research works printed but not linked: 6
- Baust, 2014, Analysis of the efficacy scn vs. Argon cryoablation devices in an in vivo-like 3-D tissue engineered prostate and renal model, Cryobiology
- Hollister, 1998, Effects of freezing on cell viability and mechanisms of cell death in a human prostate cell line, Mol. Urol., 2, 13
- Piro, 2004, Apoptosis, bcl-2 antisense, and cancer therapy, Oncology (Williston Park), 18, 5
- Van Buskirk, 2004, Hypothermic storage and cryopreservation – the issues of successful short-term and long term preservation of cells and tissues, BioProcess Int., 2, 42
- T. Van der Kwast, Histological effects of prostate therapies, in: Montréal Conference on Focal Therapy for Prostate Cancer, Montreal, Canada, 2012.
- A. Villers, Hifu (ablaterm): the French hemi-ablation study, in: Montréal Conference on Focal Therapy for Prostate Cancer, Montreal, Canada, 2012.
Cited by
Sorted by citations
Percutaneous image-guided cryoablation: current applications and results in the oncologic field
Cazzato, R. L., Garnon, J., Ramamurthy, N. K., Koch, G., Tsoumakidou, G., Caudrelier, J. M., Arrigoni, F., Zugaro, L., Barile, A., Masciocchi, C., et al. (2016) · Medical Oncology · doi:10.1007/s12032-016-0848-3 · Cited by 152
Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation
Kwak, K., Yu, B., Lewandowski, R. J., & Kim, D. (2022) · Theranostics · doi:10.7150/thno.67530 · Cited by 130
Fine, R. E., Gilmore, R. C., Dietz, J. R., Boolbol, S. K., Berry, M. P., Han, L. K., Kenler, A. S., Sabel, M. S., Tomkovich, K. R., VanderWalde, N. A., et al. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-10501-4 · Cited by 122
Immunotherapy Plus Cryotherapy: Potential Augmented Abscopal Effect for Advanced Cancers
Abdo, J., Cornell, D. L., Mittal, S. K., & Agrawal, D. K. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00085 · Cited by 122
Murphy, M. C., Wrobel, M. M., Fisher, D. A., Cahalane, A. M., & Fintelmann, F. J. (2022) · American Journal of Roentgenology · doi:10.2214/ajr.21.27099 · Cited by 94
Metadata
- Authors
- Baust, J. G., Gage, A. A., Bjerklund Johansen, T. E., & Baust, J. M.
- Affiliations
- Binghamton University (US)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Baust, J.G.
- ORCID
- Baust, J.M.
- Venue
- Cryobiology
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 68
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0011-2240 (ISSN-L)
- PMC
- PMC3976170
- OpenAlex
- W1985256611
- Cited by
- 239
- References
- 152
- Citations by year
- 2026: 29 · 2025: 20 · 2024: 22 · 2023: 22 · 2022: 23 · 2021: 26 · 2020: 17 · 2019: 17 · 2018: 14 · 2017: 17 · 2016: 12 · 2015: 11 · 2014: 4
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cryobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Keywords
- cryoablation, cryosurgery, tumor biology, tumor microenvironment, cancer stem cells, tumor angiogenesis, antitumor immunity, adjunctive therapy, cancer hallmarks
- MeSH terms
- Combined Modality Therapy, Cryosurgery, Humans, Male, Neovascularization, Pathologic, Prostate, Prostatic Neoplasms, Neoplastic Stem Cells, Apoptosis, Tumor Microenvironment
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