The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Analgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain
Open accessAbstract
BACKGROUND Chronic established pain, especially that following nerve injury, is difficult to treat and represents a largely unmet therapeutic need. New insights are urgently required, and we reasoned that endogenous processes such as cooling-induced analgesia may point the way to novel strategies for intervention. Molecular receptors for cooling have been identified in sensory nerves, and we demonstrate here how activation of one of these, TRPM8, produces profound, mechanistically novel analgesia in chronic pain states. RESULTS We show that activation of TRPM8 in a subpopulation of sensory afferents (by either cutaneous or intrathecal application of specific pharmacological agents or by modest cooling) elicits analgesia in neuropathic and other chronic pain models in rats, thereby inhibiting the characteristic sensitization of dorsal-horn neurons and behavioral-reflex facilitation. TRPM8 expression was increased in a subset of sensory neurons after nerve injury. The essential role of TRPM8 in suppression of sensitized pain responses was corroborated by specific knockdown of its expression after intrathecal application of an antisense oligonucleotide. We further show that the analgesic effect of TRPM8 activation is centrally mediated and relies on Group II/III metabotropic glutamate receptors (mGluRs), but not opioid receptors. We propose a scheme in which Group II/III mGluRs would respond to glutamate released from TRPM8-containing afferents to exert an inhibitory gate control over nociceptive inputs. CONCLUSIONS TRPM8 and its central downstream mediators, as elements of endogenous-cooling-induced analgesia, represent a novel analgesic axis that can be exploited in chronic sensitized pain states.
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Cites
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
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Identification of a cold receptor reveals a general role for TRP channels in thermosensation
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ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
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A TRP Channel that Senses Cold Stimuli and Menthol
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,355
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TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista, D. M., Jordt, S.-E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,932
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
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Cited by
TRPM8 Is Required for Cold Sensation in Mice
Dhaka, A., Murray, A. N., Mathur, J., Earley, T. J., Petrus, M. J., & Patapoutian, A. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.024 · Cited by 930
Attenuated Cold Sensitivity in TRPM8 Null Mice
Colburn, R. W., Lubin, M. L., Stone, D. J., Wang, Y., Lawrence, D., D'Andrea, M. R., Brandt, M. R., Liu, Y., Flores, C. M., & Qin, N. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.017 · Cited by 771
Nilius, B., & Szallasi, A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008268 · Cited by 506
Flatters, S. J. L., Dougherty, P. M., & Colvin, L. A. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex229 · Cited by 391
Migraine pathophysiology: lessons from mouse models and human genetics
Ferrari, M. D., Klever, R. R., Terwindt, G. M., Ayata, C., & van den Maagdenberg, A. M. J. M. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70220-0 · Cited by 387
Metadata
- Authors
- Proudfoot, C. J., Garry, E. M., Cottrell, D. F., Rosie, R., Anderson, H., Robertson, D. C., Fleetwood-Walker, S. M., & Mitchell, R.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 16
- Issue
- 16
- Pages
- 1591-1605
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2113737911
- Cited by
- 419
- References
- 56
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Proudfoot, C. J., Garry, E. M., Cottrell, D. F., Rosie, R., Anderson, H., Robertson, D. C., Fleetwood-Walker, S. M., & Mitchell, R. (2006). Analgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain. Current Biology. https://doi.org/10.1016/j.cub.2006.07.061
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