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Cited by 82Neurotransmitter Receptor Influence on BehaviorZebrafish Biomedical Research ApplicationsNeuroscience and Neuropharmacology Research

Firing dynamics and modulatory actions of supraspinal dopaminergic neurons during zebrafish locomotor behavior

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Jay, Michael, De Faveri, Francesca, McDearmid, Jonathan Robert·2015·Current Biology
DOI 10.1016/j.cub.2014.12.033PMC PMC4331284
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Abstract

BACKGROUND: Dopamine (DA) has long been known to have modulatory effects on vertebrate motor circuits. However, the types of information encoded by supraspinal DAergic neurons and their relationship to motor behavior remain unknown. RESULTS: By conducting electrophysiological recordings from awake, paralyzed zebrafish larvae that can produce behaviorally relevant activity patterns, we show that supraspinal DAergic neurons generate two forms of output: tonic spiking and phasic bursting. Using paired supraspinal DA neuron and motoneuron recordings, we further show that these firing modes are associated with specific behavioral states. Tonic spiking is prevalent during periods of inactivity while bursting strongly correlates with locomotor output. Targeted laser ablation of supraspinal DA neurons reduces motor episode frequency without affecting basic parameters of motor output, strongly suggesting that these cells regulate spinal network excitability. CONCLUSIONS: Our findings reveal how vertebrate motor circuit flexibility is temporally controlled by supraspinal DAergic pathways and provide important insights into the functional significance of this evolutionarily conserved cell population.

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  • Paired recordings of diencephalospinal dopaminergic neurons and spinal MNs during swimming show that these two populations often burst together.

    “Paired recordings of diencephalospinal dopaminergic neurons and spinal MNs during swimming show that these two populations often burst together (Jay et al., 2015).”

    From Modeling spinal locomotor circuits for movements in developing zebrafish (2021) · cites this paper as Jay et al., 2015

    In Results, ‘Relationship between DDN Activity and Motor Behavior’ (page unavailable), the paper reports simultaneous recordings of DDNs and spinal motoneurons or muscle fibers; 43 of 45 DDN bursts occurred during the beat component of fictive swimming. It describes the spinal recording as rhythmic synaptic drive, however, rather than showing that motoneurons themselves burst alongside DDNs. (LLM, conf=0.82)

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Authors
Jay, M., De Faveri, F., & McDearmid, J. R.
Affiliations
University of Leicester (GB)
Corresponding author
McDearmid, Jonathan Robert
Venue
Current Biology
Publisher
Elsevier BV
Published
2015-02
Volume
25
Issue
4
Pages
435-444
ISSN
0960-9822 (ISSN-L)
DOI
10.1016/j.cub.2014.12.033
PMC
PMC4331284
OpenAlex
W1988448671
Cited by
82
References
2
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 14 · 2020: 15 · 2019: 4 · 2018: 7 · 2017: 11 · 2016: 4 · 2015: 4
FWCI
4.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Biology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion, cc-by)
Funders
Biotechnology and Biological Sciences Research Council (1068275, BBE015352)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dopamine, zebrafish larvae, locomotor behavior, tonic spiking, motor neurons, laser ablation, behavioral state
MeSH terms
Animals, Diencephalon, Locomotion, Motor Neurons, Zebrafish, Dopaminergic Neurons

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