Autophagy: Starvation Relieves Transcriptional Repression of ATG Genes
Open accessAbstract
Autophagy is a highly regulated process about which relatively little is known, particularly concerning the transcriptional control of autophagy regulation. A new study identifies a key regulator of the expression of autophagy-related genes, thereby providing insights into the signalling pathways modulating autophagy.
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The authors identified 20 targets related to autophagy activation and validated them by qPCR: ATG10, ATG14, ATG16L1, ATG3, ATG4, ATG7, ATG9A, BCL2, GABARAP, GABARAPL1, MAP1LC3B, NBR1, OPTN, PINK1, SQSTM1, ULK1, ULK2, UVRAG, WDR45, WIPI1.
“In a first case, starting from experimental data available in the literature, we identified 20 targets related to autophagy activation and validated them by qPCR: ATG10, ATG14, ATG16L1, ATG3, ATG4, ATG7, ATG9A, BCL2, GABARAP, GABARAPL1, MAP1LC3B, NBR1, OPTN, PINK1, SQSTM1, ULK1, ULK2, UVRAG, WDR45, WIPI1 (Fig. 2) [18–27].”
From A gene toolbox for monitoring autophagy transcription (2021) · cites this paper as [25]
The Main Text (page unavailable) describes autophagy-related ATG genes and reports that a yeast study measured a subset by RT-qPCR; it also discusses ATG7, Atg8 and Atg9 in autophagy. It does not establish the full list of 20 targets. The citing sentence attributes the selection and qPCR validation to its own authors, not to this source. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThe restricted "induction list" for the prediction of autophagy activation state is made of 20 targets and was obtained by combining data from previous publications documenting increased mRNA expression following autophagy induction.
“The restricted “induction list” for the prediction of autophagy activation state, made by 20 targets, was obtained combining data from previous publications [18–27], in which have been documented the increase of the mRNA expression following autophagy induction.”
From A gene toolbox for monitoring autophagy transcription (2021) · cites this paper as [25]
The Main Text (page not specified) says that a subset of yeast ATG genes is strongly transcriptionally induced after nitrogen starvation, supporting the expression-increase rationale. It does not describe a 20-target induction list, its use to predict autophagy activation state, or its compilation from previous publications. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe activation list was derived from comparison of publications reporting conditions of gene up-regulation upon autophagy activation.
“A so called “activation list” has been derived from the comparison of publications, in which we reported conditions of gene up-regulation upon autophagy activation [18–27].”
From A gene toolbox for monitoring autophagy transcription (2021) · cites this paper as [25]
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A gene toolbox for monitoring autophagy transcription
Bordi, M., De Cegli, R., Testa, B., Nixon, R. A., Ballabio, A., & Cecconi, F. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04121-9 · Cited by 131 · see citing works
- Authors
- Devenish, R. J., & Prescott, M.
- Affiliations
- Monash University (AU)
- Corresponding author
- Devenish, Rodney J.
- Prescott, Mark
- ORCID
- Devenish, Rodney J.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 25
- Issue
- 6
- Pages
- R238-R240
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2166499611
- Cited by
- 9
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, starvation, autophagy-related genes, transcriptional repression, transcriptional regulation, autophagy regulation, signaling pathways
- MeSH terms
- Autophagy, Genes, Fungal, Mutation, Protein Kinases, Repressor Proteins, Saccharomyces cerevisiae, Transcription, Genetic, Signal Transduction, Saccharomyces cerevisiae Proteins, Histone Demethylases
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