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Cited by 29Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesParkinson's Disease Mechanisms and Treatments

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Dopamine Modulates Option Generation for Behavior

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Ang, Yuen-Siang, Manohar, Sanjay, Plant, Olivia, Kienast, Annika, Le Heron, Campbell, Muhammed, Kinan, Hu, Michele, Husain, Masud·2018·Current Biology
DOI 10.1016/j.cub.2018.03.069PMC PMC5981001
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Abstract

Animals make innumerable decisions every day, each of which involves evaluating potential options for action. But how are options generated? Although much is now known about decision making when a fixed set of potential options is provided, surprisingly little progress has been made on self-generated options. Some researchers have proposed that such abilities might be modulated by dopamine. Here, we used a new measure of option generation that is quantitative, objective, and culture fair to investigate how humans generate different behavioral options. Participants were asked to draw as many different paths (options) as they could between two points within a fixed time. Healthy individuals (n = 96) exhibited a trade-off between uniqueness (how individually different their options were) and fluency (number of options), generating either many similar or few unique options. To assess influence of dopamine, we first examined patients with Parkinson's disease (n = 35) ON and OFF their dopaminergic medication and compared them to elderly healthy controls (n = 34). Then we conducted a double-blind, placebo-controlled crossover study of the D2 agonist cabergoline in healthy older people (n = 29). Across both studies, dopamine increased fluency but diminished overall uniqueness of options generated, due to the effect of fluency trading off with uniqueness. Crucially, however, when this trade-off was corrected for, dopamine was found to increase uniqueness for any given fluency. Three carefully designed control studies showed that performance on our option-generation task was not related to executing movements, planning actions, or selecting between generated options. These findings show that dopamine plays an important role in modulating option generation.

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  • Under these drugs, healthy volunteers were able to connect two points on a grid with a greater number of different trajectories in a fixed time than without pharmacological intervention.

    “Под влиянием этих препаратов здоровым добровольцам удавалось соединить две точки на решетке бjльшим количеством разных траекторий за фиксированное время, чем без фармакологического вмешательства.”

    From Когнитивные механизмы дисфункционального принятия решений при психических расстройствах (2025) · cites this paper as Ang et al., 2018

    The Results and Discussion report that healthy volunteers generated more path options after cabergoline than after placebo. The Introduction and STAR Methods describe a four-minute task drawing paths between two points on a touchscreen, not on a grid; the healthy-volunteer comparison tested cabergoline, not multiple drugs. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Pharmacologically induced activation of option generation essentially did not have a significant effect on the quality of decisions made.

    “Фармакологически индуцированная активация процесса генерации опций, по сути, не оказывала существенного влияния на качество принимаемых решений.”

    From Когнитивные механизмы дисфункционального принятия решений при психических расстройствах (2025) · cites this paper as Ang et al., 2018

    In Results and Discussion (Figure 7 and Figure S7; page not available), the paper reports that dopamine improved option generation but had no effect on fluency in an option-selection control task. That task measured how many targets participants connected, not the quality of their decisions, so the claimed lack of an effect on decision quality is not established. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • However, the expansion of the range of alternatives in them was achieved by reducing the uniqueness of each proposed variant, i.e., the many trajectories they invented differed little from each other.

    “Однако расширение круга альтернатив у них достигалось за счет снижения уникальности каждого из предлагаемых вариантов, т.е.придуманные ими многочисленные траектории мало отличались друг от друга.”

    From Когнитивные механизмы дисфункционального принятия решений при психических расстройствах (2025) · cites this paper as Ang et al., 2018

  • Since option generation is modulated by the dopaminergic system, it can be enhanced by pharmacological drugs, for example dopamine receptor agonists or reuptake inhibitors.

    “Поскольку процесс генерации опций модулируется дофаминэргической системой, его можно усилить фармакологическими препаратами, например агонистами рецепторов к дофамину (Ang et al., 2018) или ингибиторами его обратного захвата (Ang et al., 2022).”

    From Когнитивные механизмы дисфункционального принятия решений при психических расстройствах (2025) · cites this paper as Ang et al., 2018

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Metadata

Authors
Ang, Y.-S., Manohar, S., Plant, O., Kienast, A., Le Heron, C., Muhammed, K., Hu, M., & Husain, M.
Affiliations
  • John Radcliffe Hospital (GB)
  • University of Oxford (GB)
Corresponding author
Ang, Yuen-Siang
ORCID
Venue
Current Biology
Publisher
Elsevier BV
Published
2018-05
Volume
28
Issue
10
Pages
1561-1569.e3
ISSN
0960-9822 (ISSN-L)
DOI
10.1016/j.cub.2018.03.069
PMC
PMC5981001
OpenAlex
W2799519376
Cited by
29
References
2
Citations by year
2026: 1 · 2025: 7 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 3
FWCI
1.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Biology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • A∗STAR National Science Scholarship
  • Medical Research Council (MR/P00878X)
  • Wellcome Trust (206330/Z/17/Z)
  • NIH Research (NIHR) Oxford Biomedical Research Centre
  • Parkinson’s United Kingdom
  • NIHR Oxford Biomedical Research Centre
  • Dementias and Neurodegenerative Diseases Research Network (DeNDRoN
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
dopamine, option generation, decision-making, fluency, Parkinson's disease, cabergoline, dopamine D2 receptor agonist, dopaminergic therapy
MeSH terms
Cabergoline, Adult, Aged, Decision Making, Dopamine, Double-Blind Method, Female, Humans, Individuality, Male, Middle Aged, Parkinson Disease, Dopamine Agents, Dopamine Agonists, Young Adult

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