Orbitofrontal cortex: a ‘non-rewarding’ new treatment target in depression?
Open accessAbstract
Self-perpetuating activity in lateral orbitofrontal regions has been theorized to sustain the negative thoughts and emotions of depression. A new study demonstrates that disrupting such activity may yield rapid improvements in mood state, pointing the way to novel treatment strategies.
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References 17 · Cited by 31
- Authors
- Downar, J.
- Affiliations
- University Health Network (CA)
- Corresponding author
- Downar, Jonathan
- ORCID
- Downar, Jonathan
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 29
- Issue
- 2
- Pages
- R59-R62
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2912269347
- Cited by
- 31
- References
- 17
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 6
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-03-04)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- orbitofrontal cortex, depression, negative thinking, mood improvement, treatment goals
- MeSH terms
- Depression, Electric Stimulation, Humans, Magnetic Resonance Imaging, Reward, Prefrontal Cortex
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