Neuroscience: Sex Hormones at Work in the Neocortex
Open accessAbstract
Sex hormones have easy access to the brain and their receptors are expressed by cortical neurons. Until recently, little was known about what impact, if any, they have on cortical processing. New data reveal that estradiol potently alters inhibitory neurotransmission in the neocortex.
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Gonadal hormones shape brain structure, function, and gene expression networks that could influence stress responses.
“Although the cause of these differences is unknown, other studies show that gonadal hormones shape brain structure (23–26), function (27), and gene expression networks (28) that could influence stress responses.”
From Sexual differentiation of neural mechanisms of stress sensitivity during puberty (2023) · cites this paper as [24]
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Sexual differentiation of neural mechanisms of stress sensitivity during puberty
Wright, E. C., Luo, P. X., Zakharenkov, H. C., Serna Godoy, A., Lake, A. A., Prince, Z. D., Sekar, S., Culkin, H. I., Ramirez, A. V., Dwyer, T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306475120 · Cited by 34 · see citing works
- Authors
- Delevich, K., Piekarski, D., & Wilbrecht, L.
- Affiliations
- University of California, Berkeley (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Wilbrecht, Linda
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 29
- Issue
- 4
- Pages
- R122-R125
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2915495207
- Cited by
- 10
- References
- 0
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sex hormones, estradiol, neocortex, inhibitory neurotransmission, cortical neurons, sex hormone receptors, cortical processing
- MeSH terms
- Animals, Estrus, Female, Synaptic Transmission, Neurons, Gonadal Steroid Hormones, Neocortex
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