Dynamic alteration of soluble serum biomarkers in healthy aging
Abstract
Dysbalanced production of inflammatory cytokines is involved in immunosenescence in aging. The age-related changes of the levels of circulating inflammatory mediators and their clinical importance have not been investigated until recently. Still, little is known about the influence of aging on circulating levels of many cytokines, chemokines, growth factors, and angiogenic factors. In the present study, we evaluated the effect of aging on 30 different serum biomarkers involved in pro- and anti-inflammatory responses using multianalyte LabMAP Luminex technology. The simultaneous measurement of serological markers has been done in 397 healthy subjects between 40 and 80 years old. We demonstrated an increase in serum interferon-gamma-inducible chemokines (MIG and IP-10), eotaxin, chemoattractant for eosinophils, and soluble TNFR-II with advancing age. Serum levels of EGFR and EGF, important regulators of cell growth and differentiation, were decreased with age in healthy donors. These data suggest novel pathways, which may be involved in age-associated immunosenescence.
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CXCL9 increases with age in humans.
“Some studies in humans have found CXCL9 to increase with age93–98”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [96]
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References 54 · Cited by 95
- Authors
- Shurin, G. V., Yurkovetsky, Z. R., Chatta, G. S., Tourkova, I. L., Shurin, M. R., & Lokshin, A. E.
- Affiliations
- UPMC Hillman Cancer Center (US)
- Corresponding author
- Shurin, Galina V.
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 39
- Issue
- 2
- Pages
- 123-129
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W1970657176
- Cited by
- 95
- References
- 54
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 8 · 2017: 8 · 2016: 3 · 2015: 13 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- healthy aging, immunosenescence, serum biomarkers, inflammatory cytokines, chemokines, MIG, CXCL10, eotaxin, soluble TNF receptor 2, EGFR, epidermal growth factor, angiogenic factors, growth factors
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Epidermal Growth Factor, Female, Humans, Male, Middle Aged, Reference Values, Solubility, Biomarkers, Age Distribution, Receptors, Tumor Necrosis Factor, Type II, Chemokine CXCL10, Chemokine CXCL9, Chemokine CCL11, ErbB Receptors
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