Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity
Open accessAbstract
The proinflammatory cytokine Interleukin 1 beta (IL-1beta) is elevated in obese individuals and rodents and it is implicated in impaired insulin secretion, decreased cell proliferation and apoptosis of pancreatic beta cells. In this study we describe the therapeutic effects by an IL-1beta antibody to improve glucose control in hyperglycemic mice with diet-induced obesity. After 13 weeks of treatment the IL-1beta antibody treated group showed reduced glycated hemoglobin (( *)P=0.049), reduced serum levels of proinsulin (( *)P=0.015), reduced levels of insulin and smaller islet size (( *)P=1.65E-13) relative to the control antibody treated group. Neutralization of IL-1beta also significantly reduced serum amyloid A (SAA) which is an indicator of inflammation-induced acute phase response (( *)P=0.024). While there was no improvement of obesity, a significant improvement of glycemic control and of beta cell function is achieved by this pharmacological treatment which may slow/prevent disease progression in Type 2 Diabetes.
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The NLRP-3 inflammasome plays a role in the pathophysiology of many inflammatory diseases, including obesity, insulin resistance, and diabetes.
“The NLRP-3 inflammasome plays a role in the pathophysiology of many inflammatory diseases, including obesity, insulin resistance, and diabetes (21,31–35).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [33]
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References 71 · Cited by 160
- Authors
- Osborn, O., Brownell, S. E., Sanchez-Alavez, M., Salomon, D., Gram, H., & Bartfai, T.
- Affiliations
- Scripps Research Institute (US)
- Novartis (Switzerland) (CH)
- Corresponding author
- Bartfai, T.
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 44
- Issue
- 1
- Pages
- 141-148
- ISSN
- 1043-4666 (ISSN-L)
- PMC
- PMC3063393
- OpenAlex
- W1992012350
- Cited by
- 160
- References
- 71
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 8 · 2014: 18 · 2013: 13 · 2012: 13
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Novartis
- National Institute of Neurological Disorders and Stroke (R01NS043501)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- IL-1β, diet-induced obesity, glycemic control, type 2 diabetes, beta-cell function, proinsulin, serum amyloid A, inflammation, hyperglycemia, HbA1c, islet size
- MeSH terms
- Serum Amyloid A Protein, Animals, Antibodies, Blood Glucose, Diet, Glycated Hemoglobin, Insulin Resistance, Male, Obesity, Mice, Interleukin-1beta
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