1α,25-dihydroxyvitamin D3 inhibits CD40l-induced pro-inflammatory and immunomodulatory activity in human monocytes
Abstract
CD40 ligand (CD40L) stimulation induces proinflammatory and immunomodulatory activity in monocytes. Here, we report on the effects of the steroid hormone 1alpha,25-dihydroxyvitamin D3 (1,25D3) on human blood monocytes that have been stimulated with the CD40L ligand. Co-treatment of CD40L-stimulated monocytes with 1,25D3 resulted in reduced production and secretion of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, as well as in reduced expression of the surface co-stimulatory molecules CD80 and CD86. In addition, costimulation of CD4+ T lymphocytes by monocytes co-treated with CD40L and 1,25D3 resulted in reduced cell proliferation and diminished interferon (IFN)-gamma but enhanced IL-10 production by CD4+ T cells. Finally, 1,25D3 interfered with the ability of CD40L to rescue monocytes from apoptosis induced by serum withdrawal. These findings suggest that 1,25D3 may regulate the interaction of monocytes with T cells or other cell types that express CD40L, thus influencing the outcome of the immune or inflammatory response.
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Vitamin D metabolites decrease the secretion of IL-6 and TNF-α.
“For example, vitamin D metabolites have been shown to decrease the secretion of IL-6 and TNF-α [162], enhance the expression of anti-inflammatory cytokines such as interleukin 10 (IL–10) from activated B cells [163], and to direct dendritic cells (DCs) toward a more tolerogenic state [164].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [162]
Vitamin D has an effect on the immune system and can directly affect immune cells.
“It is well known that vitamin D has an effect on immune system and can directly affect immune cells.”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [162]
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References 64 · Cited by 221
- Authors
- Almerighi, C., Sinistro, A., Cavazza, A., Ciaprini, C., Rocchi, G., & Bergamini, A.
- Affiliations
- University of Rome Tor Vergata (IT)
- University of Parma (IT)
- Corresponding author
- Bergamini, Alberto
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 45
- Issue
- 3
- Pages
- 190-197
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2045480275
- Cited by
- 221
- References
- 64
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 9 · 2023: 13 · 2022: 20 · 2021: 18 · 2020: 19 · 2019: 18 · 2018: 3 · 2017: 22 · 2016: 16 · 2015: 12 · 2014: 11 · 2013: 15 · 2012: 13
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- 1,25-dihydroxyvitamin D3, CD40 ligand, CD40, human monocytes, inflammatory cytokines, TNF-α, IL-1β, CD80, CD86, IL-10, interferon-gamma, monocyte apoptosis, serum deprivation, immunomodulation, vitamin D
- MeSH terms
- Calcitriol, Humans, Immunologic Factors, Monocytes, CD40 Ligand
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