The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice
Abstract
The hypothesis of this study was that cells of the monocyte/macrophage lineage (Mo/Mp) exhibit an impaired transition from pro-inflammatory to pro-healing phenotypes in wounds of diabetic mice, which contributes to deficient healing. Mo/Mp isolated from excisional wounds in non-diabetic db/+ mice exhibited a pro-inflammatory phenotype on day 5 post-injury, with high level expression of the pro-inflammatory molecules interleukin-1β, matrix metalloprotease-9 and inducible nitric oxide synthase. Wound Mo/Mp exhibited a less inflammatory phenotype on day 10 post-injury, with decreased expression of the pro-inflammatory molecules and increased expression of the alternative activation markers CD206 and CD36. In contrast, in db/db mice, the pro-inflammatory phenotype persisted through day 10 post-injury and was associated with reduced expression of insulin-like growth factor-1, transforming growth factor-β1 and vascular endothelial growth factor. Reduced levels of these growth factors in wounds of db/db mice may have contributed to impaired wound closure, reduced granulation tissue formation, angiogenesis and collagen deposition. The persistent pro-inflammatory wound Mo/Mp phenotype in db/db mice may have resulted from elevated levels of pro-inflammatory interleukin-1β and interferon-γ and reduced levels of anti-inflammatory interleukin-10 in the wound environment. Our findings are consistent with the hypothesis that dysregulation of Mo/Mp phenotypes contributes to impaired healing of diabetic wounds.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We recently demonstrated that Mp exhibit a sustained proinflammatory phenotype in wounds of diabetic mice (14)”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [14]
In the citing paper
“Bone marrow transfer from wild-type to db/db mice resulted in wound healing that was similar to db/db mice that had not received bone marrow transfer (compare Fig. 7A–D with Fig. 6A–D and refs. 14,15)”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [14]
In the citing paper
“We and others have observed a persistent proinflammatory wound Mp phenotype in diabetic humans and mice (14,29) and in chronic venous ulcers (30).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [14]
In the citing paper
“Recent studies have shown that Mp phenotypes change over the different phases of tissue repair and that the sequential appearance of these phenotypes may be required for efficient repair (11,14,29,49,50).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [14]
In the citing paper
“In fact, either premature changes in phenotype or delayed/impaired changes in phenotype have been associated with impaired healing (14,29,49).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [14]
In the citing paper
“Indeed, in mouse and human skin wounds and in injured mouse kidney, Mp expression of CD206 increases during the later stages of repair [33,60,61,63].”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [60]
In the citing paper
“In mouse skin wounds, IL-4 mRNA and protein are not detectable at early or late time-points [60,71].”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [60]
In the citing paper
“Mp expression of mRNA and protein for these cytokines exhibits an early peak and subsequent decline after skin wounding [33,60] or toxin-induced muscle injury in mice [65], consistent with an early M1-like phenotype.”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [60]
In the citing paper
“The M1-associated cytokines IL-1, TNF-␣, IL-6, and IL-12 are expressed by Mp during the first few hours to days after acute injury in numerous tissues, including skin [33,60,61], liver [62], kidney [63], and skeletal muscle [57,64].”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [60]
In the citing paper
“Indeed, during mouse skin wound healing, Mp expression of TGF- mRNA and protein increases over the first 7-10 days postinjury, whereas proinflammatory cytokine production decreases [33,60], consistent with the expression of an M2a-like phenotype during the later stages of repair.”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [60]
In the citing paper
“Additionally, a comprehensive in vivo Mp phenotype cannot be deduced solely from a limited set of phenotypic markers, as different M2a-associated genes or proteins can exhibit entirely different temporal regulation and can be coexpressed with M1-associated markers [19,25,33,60,78].”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [60]
Citations
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Human skin wounds: A major and snowballing threat to public health and the economy
Sen, C. K., Gordillo, G. M., Roy, S., Kirsner, R., Lambert, L., Hunt, T. K., Gottrup, F., Gurtner, G. C., & Longaker, M. T. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00543.x · Cited by 2,965
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
(1975) · PubMed Central · Cited by 1,437
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205
Cited by
Sorted by citations
Items 201–300 of 342
Diabetes Inhibits Gr-1+ Myeloid Cell Maturation via Cebpa Deregulation
Wicks, K., Torbica, T., Umehara, T., Amin, S., Bobola, N., & Mace, K. A. (2015) · Diabetes · doi:10.2337/db14-1895 · Cited by 17
Human macrophage response to microbial supernatants from diabetic foot ulcers
Deusenbery, C. B., Kalan, L., Meisel, J. S., Gardner, S. E., Grice, E. A., & Spiller, K. L. (2019) · Wound Repair and Regeneration · doi:10.1111/wrr.12752 · Cited by 19
Halfter, N., Espinosa‐Cano, E., Pontes-Quero, G. M., Ramírez-Jiménez, R. A., Heinemann, C., Möller, S., Schnabelrauch, M., Wiesmann, H., Hintze, V., & Aguilar, M. R. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14030160 · Cited by 16
Guo, M., Xia, Z., Hong, Y., Ji, H., Li, F., Liu, W., Li, S., Xin, H., Tan, K. W., & Lian, Z. (2023) · Journal of Inflammation · doi:10.1186/s12950-023-00357-8 · Cited by 16
Ding, X., Yang, C., Li, Y., He, T., Xu, Y., Cheng, X., Song, J., Xue, N., Min, W., Feng, W., et al. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae037 · Cited by 16
Pericytes in Cutaneous Wound Healing
Morikawa, S., Iribar, H., Gutiérrez‐Rivera, A., Ezaki, T., & Izeta, A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-16908-4_1 · Cited by 17
Skin Wounding–Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency
Barman, P. K., Pang, J., Urao, N., & Koh, T. J. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801481 · Cited by 16
Self-citationG-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds
Cooper, P. O., Kleb, S. S., Noonepalle, S. K. R., Amuso, V. M., Varshney, R., Rudolph, M. C., Dhaliwal, T. K., Nguyen, D. V., Mazumder, M. F., Babirye, N. S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114288 · Cited by 15
Silva, J. C., Fantuzzi, G., Minshall, R. D., Wu, S., Oddo, V. M., & Koh, T. J. (2024) · Wound Repair and Regeneration · doi:10.1111/wrr.13200 · Cited by 16
Self-citationMondal, N. S., Islam, A., Gautam, M. K., Mondal, S., Ahmed, M., Jamir, S. I., Khongwir, L. D., & Mahajon, B. (2025) · Current Diabetes Reviews · doi:10.2174/0115733998368222250509185511 · Cited by 15
Wang, B., Kasper, M., Laffer, B., zu Hörste, G. M., Wasmuth, S., Busch, M., Jalilvand, T. V., Thanos, S., Heiligenhaus, A., Bauer, D., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573955 · Cited by 14
Wang, Y., He, Y., Abraham, B., Rouhani, F. N., Brantly, M., Scott, D. E., & Reed, J. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051078 · Cited by 14
Wound Healing Effects of Rose Placenta in a Mouse Model of Full-Thickness Wounds
Kim, Y. W., Baek, S. R., Lee, E. S., Lee, S. H., Moh, S. H., Kim, S. Y., Moh, J. H., Kondo, C., & Cheon, Y. W. (2015) · Archives of Plastic Surgery · doi:10.5999/aps.2015.42.6.686 · Cited by 14
Advances in chitosan-based materials for oral ulcer treatment
Zhang, X., Lei, J., Qu, T., & Zhang, X. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124110 · Cited by 13
Applications of chitosan-based hydrogels in diabetic wound healing: A review
Li, W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147264 · Cited by 13
Ali, M. M., Ibrahim, S. F., Elrewieny, N. M., Elyamany, A. M., Khalil, W. K. B., Shalby, A. B., & Khater, S. A. (2022) · Biomedicines · doi:10.3390/biomedicines10112919 · Cited by 13
Wang, Z., Zhang, W., Jiang, Y., Chen, A.-J., Pi, J.-K., Hu, J.-G., Zhang, Y., Yang, X., Huang, F., & Xie, H. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01110 · Cited by 13
Sanjurjo, L., Castelblanco, E., Julve, J., Villalmanzo, N., Téllez, É., Ramírez‐Morros, A., Alonso, N., Mauricio, D., & Sarrias, M. (2023) · Antioxidants · doi:10.3390/antiox12051083 · Cited by 13
Haas, M. R., Nguyen, D. V., & Shook, B. A. (2021) · Biomedicines · doi:10.3390/biomedicines9121752 · Cited by 12
Liu, H., Wu, B., Shi, X., Cao, Y., Zhao, X., Liang, D., Qin, Q., Liang, X., Lu, W., Wang, D., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.903779 · Cited by 13
The mutual regulation between γδ T cells and macrophages during wound healing
Hu, W., Zhang, X., Sheng, H., Liu, Z., Chen, Y., Huang, Y., He, W., & Luo, G. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad087 · Cited by 13
Phagocytosis of apoptotic endothelial cells reprograms macrophages in skin wounds
Xu, M., Chen, Z., Chen, K., Ma, D., Chen, L., & DiPietro, L. (2021) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2021.100038 · Cited by 14
Lauterbach, A. L., Wallace, R. P., Alpar, A. T., Refvik, K. C., Reda, J. W., Ishihara, A., Beckman, T. N., Slezak, A. J., Mizukami, Y., Mansurov, A., et al. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00326-y · Cited by 12
The impact of osteoporosis and diabetes on fracture healing under different loading conditions
Zhang, E., Miramini, S., & Zhang, L. (2023) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2023.107952 · Cited by 12
Programmable Delivery of Fluoxetine via Wearable Bioelectronics for Wound Healing In Vivo
Li, H., Yang, H., Asefifeyzabadi, N., Baniya, P., Lopez, A. I. M., Gallegos, A., Zhu, K., Nguyen, T., Hernández, C., Zlobina, K., et al. (2024) · Advanced Materials Technologies · doi:10.1002/admt.202301115 · Cited by 11
Xiong, F., Jiang, X. J., Wu, Y., Xiong, J., Chen, Y., Wang, B., Ye, X., & Liang, X. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176953 · Cited by 11
Ernawati, D. S., Surboyo, M. D. C., Ayuningtyas, N. F., & Nagoro, A. A. B. (2020) · European Journal of Dentistry · doi:10.1055/s-0040-1715913 · Cited by 12
Programming and memory dynamics of innate leukocytes during tissue homeostasis and inflammation
Lee, C., Geng, S., Zhang, Y., Rahtes, A., & Li, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.6mr0117-027rr · Cited by 13
Mechanisms and Interventions of Diabetic Wound Healing
Feng, J., Lai, S., & Tang, D. (2025) · Current Diabetes Reviews · doi:10.2174/0115733998356905250706203510 · Cited by 14
Singh, K., Koroma, A. K., Pandey, R., Wang, Y., Cheng, J., Haas, P., Aghapour, M., Krug, L., Hainzl, A., Wlaschek, M., et al. (2025) · Advanced Science · doi:10.1002/advs.202504920 · Cited by 14
Chaithra, S. R., Nair, S. P., Chaithanya, S., Nagashree, K. S., Shreya, Paul, K., & Kumar, S. V. (2025) · 3 Biotech · doi:10.1007/s13205-025-04440-0 · Cited by 11
Wang, F., Wu, Q., Zhang, C., Kong, L., Zuo, R., Feng, K., Jia, G., Hou, M., Zou, J., Chai, Y., et al. (2023) · Small Structures · doi:10.1002/sstr.202300198 · Cited by 11
Pterostilbene accelerates wound healing response in diabetic mice through Nrf2 regulation
Ganesh, G. V., & Ramkumar, K. M. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.10.010 · Cited by 11
Wang, X., Zhang, W., Mao, L., Chen, J., Zhou, X., Wang, X., Chen, Y., Zhou, S., & Yang, R. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177865 · Cited by 10
Li, W., Chen, J., Yu, L., Ding, L., Zhang, X., Yan, L., & Shi, M. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102423 · Cited by 11
Chen, L., Zhu, L., & Cao, Y. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.06.009 · Cited by 8
Khashim, Z., Dai, D., Hong, D. Y., Ayers-Ringler, J. R., Herting, S. M., Jakaitis, D. R., Maitland, D. J., Kallmes, D. F., & Kadirvel, R. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6719 · Cited by 9
Transcriptional heterogeneity in human diabetic foot woundsPreprint
Sandoval-Schaefer, T., Phan, Q. M., Dash, B. C., Prassinos, A., Duan, K., Gazes, M. I., Vyce, S. D., Driskell, R. R., Hsia, H. C., & Horsley, V. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.16.528839 · Cited by 8
Cao, J., Zhang, X., Li, Z., Zhang, S., Guo, L., Liu, Z., An, W., Xu, L., Li, L., Long, X., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s519713 · Cited by 9
da Costa, A. C., Resende, D. P., Santos, B. D. P. O., Zoccal, K. F., Faccioli, L. H., Kipnis, A., & Junqueira‐Kipnis, A. P. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00623 · Cited by 7
Cai, F., Wang, P., Yuan, M., Chen, W., & Liu, Y. (2024) · Journal of Molecular Histology · doi:10.1007/s10735-024-10244-y · Cited by 6
Paredes, A. D., Benavidez, D., Cheng, J., Mangos, S., Patil, R. V., Donoghue, M. J., Benedetti, E., & Bartholomew, A. M. (2019) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2018.4494 · Cited by 6
He, T.-R., Tang, X.-Y., Yan, Q., Wu, X.-Y., Shi, B., & Lin, Y. (2022) · Current Medical Science · doi:10.1007/s11596-022-2602-8 · Cited by 6
Galstyan, K. O., Недосугова, Л. В., Martirosian, N. S., Nikiforov, N. G., Elizova, N. V., Kolmychkova, K. I., Sobenin, I. A., & Orekhov, A. N. (2019) · Biology · doi:10.3390/biology9010003 · Cited by 6
Nanotechnology in diabetic wound healing
Azeltine, M., Clark, A. R., Zgheib, C., & Ghatak, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816413-6.00021-6 · Cited by 6
Xiong, Z., Huo, M., Jia, Y., Zhou, C., Ma, X., Yin, H., Jiang, X., & Yu, W. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9050686 · Cited by 6
Lamponi, S. (2026) · Life · doi:10.3390/life16040538 · Cited by 6
Diabetic Foot - Recent Advances
Raghav, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102211 · Cited by 5
Corilagin enhances wound healing by modulating the macrophage phenotype in diabetic mice
Li, Y., Yu, S., Zeng, J., Zhou, S., Cui, X., Zhou, J., & Zhang, P. (2025) · The FASEB Journal · doi:10.1096/fj.202403085rr · Cited by 5
Simkin, J., Dawson, L., Simkin, M., & Muneoka, K. (2019) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2019.100026 · Cited by 5
Hautalterung – zelluläre Seneszenz
Scharffetter‐Kochanek, K., Wang, Y., Makrantonaki, E., Crișan, D., Wlaschek, M., Geiger, H., & Maity, P. (2023) · Die Dermatologie · doi:10.1007/s00105-023-05201-x · Cited by 5
Regulation of macrophage transcriptional dynamics during acute and chronic wound repair
Raja, S. R., Sk, M. H., Wajeed, S., Yangdol, R., Yadav, A., Jindal, H., Fatima, A., Siddiquie, A., Pulakat, L., Subramanian, R., et al. (2025) · Inflammation Research · doi:10.1007/s00011-025-02133-1 · Cited by 6
Deciphering the Iron Metabolism and Ferroptosis in Diabetic Wound Healing
Feng, Y.-S., Cao, Y.-C., Ouyang, Y., Wang, W.-X., & Feng, S.-L. (2025) · Current Diabetes Reviews · doi:10.2174/0115733998352547250107065356 · Cited by 4
Depletion of natural killer cells enhances wound healing in diabetic mice
Silva, J. C., & Koh, T. J. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf044 · Cited by 4
Self-citationHan, B. R., Sun, N., Wang, M., Shen, A., Yang, X., & Zhang, Q. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109052 · Cited by 4
The Role of Medicinal Plants in the Diabetic Wound Healing Process
Chaudhary, R. (2022) · Current Diabetes Reviews · doi:10.2174/1573399818666220224122142 · Cited by 4
Modulating monocyte-derived macrophage polarization in cerebral ischemic injury with hyperglycemia
Goh, A. R., Park, J., Sim, A. Y., Koo, B., Lee, Y., Kim, J. Y., & Lee, J. E. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114824 · Cited by 4
Obesity alters the macrophages’ response to Leishmania major in C57BL/6 mice
Martins, V. D., Vaz, L. G., Barbosa, S. C., Paixão, P. H. D. M., Torres, L., de Oliveira, M. F. A., Oliveira, M. D. A., Vieira, L. Q., Faria, A. M. C., & Maioli, T. U. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae171 · Cited by 4
Common Challenges in Tissue Regeneration
Eriksson, J., D’Angelo, W., & Badylak, S. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814879-2.00009-1 · Cited by 4
Bixa orellana L. and its implications in human health: Perspectives and new trends
da Silva, A. K. A., dos Santos, C. R., Carneiro, M. L. B., Joanitti, G. A., Luz, G. V. D. S., Rosa, S. S. R. F., Pinheiro, W. M., Rosa, M. F. F., Abreu, P. R. A., Fukuoka, F. M. G., et al. (2023) · Studies in natural products chemistry · doi:10.1016/b978-0-323-91294-5.00001-4 · Cited by 3
Ejiugwo, M., Rochev, Y. A., Gethin, G., & O’Connor, G. M. (2025) · In vitro models · doi:10.1007/s44164-024-00080-5 · Cited by 3
Lin, Y., He, X., Xie, X., Liu, Q., Chen, J., & Li, P. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/8881565 · Cited by 3
Shahnia, M. (2017) · Minerva Access (University of Melbourne) · Cited by 3
Kluth, M. A., Kerstan, A., Dieter, K., Niebergall‐Roth, E., Klingele, S., Jünger, M., Hasslacher, C., Daeschlein, G., Stemler, L., Meyer-Pannwitt, U., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1508134/v1 · Cited by 3
Deep skin fibroblast-mediated macrophage recruitment supports acute wound healingPreprint
Amuso, V. M., Haas, M. R., Cooper, P. O., Chatterjee, R., Hafiz, S., Salameh, S., Gohel, C., Mazumder, M. F., Josephson, V., Khorsandi, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.09.607357 · Cited by 3
Mazurek, Ł., Rybka, M., Zajdel, M., Jurak, J., Szudzik, M., Laskowska, A. K., Czuwara, J., Sulejczak, D., Salagierski, S., Dziadek, M., et al. (2025) · Macromolecular Bioscience · doi:10.1002/mabi.202500351 · Cited by 2
Gupta, R., Cooper, P. O., Chai, W., Mulagura, P., Lee, S. M., Theocharidis, G., Sidawy, A. N., Shook, B. A., & Nguyen, B.-N. H. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.70103 · Cited by 2
Marbourg, J. M., Vadala, C. P., Pyter, L. M., Sen, C. K., Schwab, J. M., & Popovich, P. G. (2025) · Journal of Neurotrauma · doi:10.1177/08977151251405884 · Cited by 2
Immune cells in diabetic wound repair: the key to better wound management
Ru, Y., Cai, Y., Cheng, G., Ma, X., Jiang, J., Song, J., Luo, Y., Zhang, Y., Zheng, Q., Wang, M., et al. (2025) · MedScience · doi:10.1007/s11684-025-1190-y · Cited by 2
Fan, X., Ma, Y., Ye, J., Li, L., Shen, H., Liu, Z., Bai, J., & Du, S. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121260 · Cited by 2
Zhou, J., Ma, Z., Ding, Y., Yan, X., & Tan, Q. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116767 · Cited by 2
Macrophages in Intestinal Wound Healing: Dichotomous Effects and Therapeutic Opportunities
Bungert, A. D., Winter, M., Pascher, A., & Becker, F. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104508 · Cited by 3
Liang, R., Shaker, E., Zhao, M., King, G. E., & Moalli, P. (2024) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2024.02.282 · Cited by 3
Hasegawa, A., Obara, K., Takaoka, N., Shirai, K., Hamada, Y., Arakawa, N., Aki, R., Hoffman, R. M., & Amoh, Y. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304676 · Cited by 2
Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases
Zhu, J., Liu, S., Liu, P., Zhai, K., & Liu, H. (2025) · Journal of Natural Medicines · doi:10.1007/s11418-025-01927-1 · Cited by 2
New Approaches in Heart Research: Prevention Instead of Cardiomyoplasty?
Gaebel, R., Lang, C. I., Vasudevan, P., Lührs, L., de Carvalho, K. A. T., Abdelwahid, E., & David, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24109017 · Cited by 2
[Analysis of sudden death caused by intestinal obstruction].
Hitosugi, M., Kitamura, O., Shigeta, A., Takatsu, A., Yoshino, Y., & Ohtsuki, M. (1997) · PubMed · Cited by 2
COMPARATIVE ANALYSIS OF RADIATION DOSES ON HEART WHEN USING VARIOUS 3D PLANNING METHODS
Brest Regional Oncology Dispensary, B., Лукьяновский, Р. В., Damashnikava, T. A., Brest Regional Oncology Dispensary, B., Hancharova, K. V., & Brest Regional Oncology Dispensary, B. (2020) · Journal of the Grodno State Medical University · doi:10.25298/2221-8785-2020-18-4-424-428 · Cited by 2
Peripheral Blood Mononuclear Cells
Carella, S., & Onesti, M. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-45453-0_26 · Cited by 2
Epigenetic integration of signaling from the regenerative environment
Geara, P., & Dilworth, F. J. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.02.003 · Cited by 1
Reeder, T. L., Zarlenga, D. S., & Dyer, R. M. (2024) · Journal of Dairy Science · doi:10.3168/jds.2023-24577 · Cited by 1
Identification of anti-inflammatory M2-like macrophages in diabetic foot ulcer
Trujillo-Páez, J. V., Campos-Rincón, P. E., Rodríguez-Carlos, A., Ayala-Luján, J. L., Rivas-Santiago, B. T., & Gonzalez-Curiel, I. E. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103044 · Cited by 1
Eager, J. M., Cortés-Troncoso, J., Kalan, L., Campbell, A. E., Rao, A. S., Weingarten, M. S., Grice, E. A., Oropallo, A., Margolis, D. J., Saçan, A., et al. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.70113 · Cited by 1
DcR3 reprograms macrophage plasticity to promote wound healing and hair regeneration.
Ou, S.-H., Chen, Y.-C., Hsieh, S.-L., & Chen, C.-C. (2026) · Journal of dermatological science (Amsterdam) · doi:10.1016/j.jdermsci.2026.01.002 · Cited by 1
Bhat, P., Satapathy, A., Yadav, N., Satapathy, A., Chandrakar, K., Satapathy, A., Bhardwaj, S. K., & Patel, N. (2026) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v16i3.7630 · Cited by 1
Xiang, W., Lei, Y., Xiang, H., Yang, Y., Jing, F., Xiong, L., Zhou, X., Wang, J., & Zhang, A. (2026) · Industrial Crops and Products · doi:10.1016/j.indcrop.2026.123829 · Cited by 1
Wu, J., Chen, Y., He, J., Mei, J., Zhu, H., & Zhou, D. (2026) · Functional & Integrative Genomics · doi:10.1007/s10142-026-01946-5 · Cited by 1
Crane, M. J., & Albina, J. E. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_12 · Cited by 1
Diabetic Cardiomyopathy: Distinct and Preventable Entity or Inevitable Consequence?
Schilling, J. D., & Mann, D. L. (2014) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-014-0417-2 · Cited by 1
Role of macrophages in systemic inflammation: wound healing
Ahmed, M. S., Rahman, M., Matin, M. A., Hossen, M. J., & Sikder, M. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822368-0.00015-3 · Cited by 1
Dermal macrophages in health and disease
Salina, A. C. G., Klopfenstein, N., Pinon, J., & Serezani, C. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821385-8.00008-1 · Cited by 2
An, H. M., Choi, Y. S., Bae, S. K., & Lee, Y. K. (2023) · Medicina · doi:10.3390/medicina59061155 · Cited by 1
Wang, P., Yin, B., Zhang, Z., Mao, S., Bao, W., Lian, W., Fan, Y., Hong, C., Su, Y., & Jia, C. (2022) · Wound Repair and Regeneration · doi:10.1111/wrr.13006 · Cited by 1
Pessoa, A. F. M. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2014.tde-20022015-085525 · Cited by 1
Mishra, M. (2017) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 1
Macrophage heterogeneity in neovascularization
Jetten, N. (2014) · doi:10.26481/dis.20140509nj · Cited by 1
Kumar, H. S., Yi, Z., Tong, S., & Annamalai, R. T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.02.556050 · Cited by 1
Geraldes, P., Robillard, S., Théroux, L., Lemay, A., Ouellet, M., Lizotte, F., & Boudreault, P. (2024) · Research Square · doi:10.21203/rs.3.rs-3840039/v1 · Cited by 1
Activated Macrophages in Repair of Skeletal Muscle Injuries
Novak, M. L. (2012) · Figshare
Movita, D. (2014) · RePub (Erasmus University Rotterdam)
Metadata
- Authors
- Mirza, R., & Koh, T. J.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Koh, Timothy J.
- ORCID
- Koh, Timothy J.
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 56
- Issue
- 2
- Pages
- 256-264
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2057864569
- Semantic Scholar
- 1f48248e2a91668cf09529b853c24fad07f4f0ba
- Cited by
- 342
- References
- 41
- Citations by year
- 2026: 20 · 2025: 32 · 2024: 29 · 2023: 35 · 2022: 30 · 2021: 23 · 2020: 29 · 2019: 25 · 2018: 21 · 2017: 21 · 2016: 18 · 2015: 21 · 2014: 17 · 2013: 10 · 2012: 10
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Illinois at Chicago
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- diabetic wound healing, macrophage polarization, inflammatory macrophages, alternative macrophage activation, db/db mice, IL-1β, MMP-9, inducible nitric oxide synthase, CD206, CD36, insulin-like growth factor I, TGF-β1, vascular endothelial growth factor, angiogenesis, granulation tissue, collagen deposition, interferon-gamma, IL-10
- MeSH terms
- Animals, Base Sequence, Diabetes Mellitus, Experimental, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Macrophages, Monocytes, Wound Healing, Wounds and Injuries, Immunophenotyping, Polymerase Chain Reaction, DNA Primers, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
