Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: A cross-sectional study
Open accessAbstract
The goal of the study was to determine the association between diabetes and inflammation in clinically diagnosed diabetes patients. We hypothesized that low-grade inflammation in diabetes is associated with the level of glucose control. Using a cross-sectional design we compared pro- and anti-inflammatory cytokines in a community-recruited cohort of 367 Mexican Americans with type 2-diabetes having a wide range of blood glucose levels. Cytokines (IL-6, TNF-α, IL-1β, IL-8) and adipokines (adiponectin, resistin and leptin) were measured using multiplex ELISA. Our data indicated that diabetes as whole was strongly associated with elevated levels of IL-6, leptin, CRP and TNF-α, whereas worsening of glucose control was positively and linearly associated with high levels of IL-6, and leptin. The associations remained statistically significant even after controlling for BMI and age (p=0.01). The association between TNF-α, however, was attenuated when comparisons were performed based on glucose control. Strong interaction effects between age and diabetes and BMI and diabetes were observed for IL-8, resistin and CRP. The cytokine/adipokine profiles of Mexican Americans with diabetes suggest an association between low-grade inflammation and quality of glucose control. Unique to in our population is that the chronic inflammation is accompanied by lower levels of leptin.
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Elevated circulating concentrations of inflammatory biomarkers are consistently found in people with T2DM.
“Elevated circulating concentrations of inflammatory biomarkers are consistently found in people with T2DM. 5,6”
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References 43 · Cited by 358
- Authors
- Mirza, S., Hossain, M., Mathews, C., Martinez, P., Pino, P., Gay, J. L., Rentfro, A., McCormick, J. B., & Fisher-Hoch, S. P.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- The University of Texas at San Antonio (US)
- The University of Texas System (US)
- Corresponding author
- Mirza, S.
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 57
- Issue
- 1
- Pages
- 136-142
- ISSN
- 1043-4666 (ISSN-L)
- PMC
- PMC3270578
- OpenAlex
- W2083277816
- Cited by
- 358
- References
- 43
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 25 · 2023: 32 · 2022: 28 · 2021: 48 · 2020: 32 · 2019: 29 · 2018: 19 · 2017: 25 · 2016: 21 · 2015: 20 · 2014: 19 · 2013: 9 · 2012: 6
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley) (submittedVersion)
- Funders
- National Center on Minority Health and Health disparities (NCMHD) (MD000170 P20)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, low-grade inflammation, cytokines, adipokines, TNF-α, interleukin-6, leptin, adiponectin, resistin, interleukin-8, C-reactive protein, glycemic control, Mexican Americans, obesity
- MeSH terms
- Adult, Blood Glucose, Cross-Sectional Studies, Demography, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Male, Models, Biological, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Body Mass Index, Odds Ratio, Mexican Americans, Statistics, Nonparametric, Inflammation Mediators, Leptin, Adiponectin
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