The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism
Open accessAbstract
Chemerin was isolated as the natural ligand of the G protein-coupled receptor ChemR23. Chemerin acts as a chemotactic factor for leukocyte populations expressing ChemR23, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Chemerin is expressed by epithelial and non-epithelial cells as an inactive precursor, present at nanomolar concentrations in plasma. Processing of the precursor C-terminus is required for generating bioactive forms of chemerin. Various proteases mediate this processing, including neutrophil serine proteases and proteases from coagulation and fibrinolytic cascades. ChemR23-expressing cells are recruited in human inflammatory diseases, such as psoriasis and lupus. In animal models, both pro-inflammatory and anti-inflammatory roles of chemerin have been reported. Recently, two other receptors for chemerin were described, GPR1 and CCRL2, but their functional relevance is largely unknown. Both chemerin and ChemR23 are also expressed by adipocytes, and the emerging role of chemerin as an adipokine regulating lipid and carbohydrate metabolism is an area of intense research.
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“Chemerin and CMKLR1 (which is expressed on immature dendritic cells, myeloid dendritic cells, macrophages, and natural killer cells) were later shown to recruit immune cells to injury sites and might affect the occurrence and development of inflammation (37, 38).”
From Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis (2021) · cites this paper as [38]
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Self-citationChemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism
Goralski, K. B., McCarthy, T. C., Hanniman, E. A., Zabel, B. A., Butcher, E. C., Parlee, S. D., Muruganandan, S., & Sinal, C. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700793200 · Cited by 867
Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic Syndrome
Bozaoglu, K., Bolton, K. A., McMillan, J. S., Zimmet, P., Jowett, J. B. M., Collier, G. R., Walder, K. R., & Segal, D. (2007) · Endocrinology · doi:10.1210/en.2007-0175 · Cited by 859
The genetic design of signaling cascades to record receptor activation
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Chemerin: at the crossroads of inflammation and obesity
Ernst, M. C., & Sinal, C. J. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.001 · Cited by 431
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The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues
Parolini, S., Santoro, A., Marcenaro, E., Luini, W., Massardi, L., Facchetti, F., Communi, D., Parmentier, M., Majorana, A., Sironi, M., et al. (2007) · Blood · doi:10.1182/blood-2006-08-038844 · Cited by 372
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Zlotnik, A., & Yoshie, O. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.008 · Cited by 1,239
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Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937
Adipokines Mediate Inflammation and Insulin Resistance
Kwon, H., & Pessin, J. E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00071 · Cited by 723
Adipokine dysregulation and adipose tissue inflammation in human obesity
Unamuno, X., Gómez‐Ambrosi, J., Rodríguez, A., Becerril, S., Frühbeck, G., & Catalán, V. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12997 · Cited by 610
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Metadata
- Authors
- Bondue, B., Wittamer, V., & Parmentier, M.
- Affiliations
- Université Libre de Bruxelles (BE)
- Corresponding author
- Parmentier, Marc
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 22
- Issue
- 5-6
- Pages
- 331-338
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2015466197
- Cited by
- 294
- References
- 61
- Citations by year
- 2026: 14 · 2025: 9 · 2024: 24 · 2023: 19 · 2022: 27 · 2021: 23 · 2020: 23 · 2019: 25 · 2018: 26 · 2017: 21 · 2016: 24 · 2015: 7 · 2014: 20 · 2013: 23 · 2012: 9
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- chemerin, ChemR23, GPR1, CCRL2, leukocyte migration, inflammation, chemotaxis, plasmacytoid dendritic cells, macrophages, natural killer cells, precursor processing, serine protease, psoriasis, lupus, adipokines, adipocytes, lipid metabolism, carbohydrate metabolism
- MeSH terms
- Amino Acid Sequence, Animals, Chemotaxis, Leukocyte, Inflammation, Oligopeptides, Chemokines, Receptors, Chemokine, Intercellular Signaling Peptides and Proteins
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