The cytokine network in acute myeloid leukemia (AML): a focus on pro- and anti-inflammatory mediators
Abstract
Cytokines exert profound effects on the progression of hematopoietic malignancies such as acute myeloid leukemia (AML). Critical roles of cytokines in the context of inflammation have gained special interest. While pro-inflammatory mediators such as IL-1β, TNF-α and IL-6 tend to increase AML aggressiveness, anti-inflammatory mediators such as TGF-β and IL-10 appear to impede AML progression. Dysregulation of the complex interactions between pro- and anti-inflammatory cytokines in AML may create a pro-tumorigenic microenvironment with effects on leukemic cell proliferation, survival and drug-resistance. This article summarizes current knowledge about the functions of pro- and anti-inflammatory cytokines in AML, their modes of action, and therapeutic interventions with potential to improve clinical outcomes for AML patients.
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Management of acute and chronic inflammatory conditions including infections may modify risk for clonal expansion and subsequent malignancy.
“thus supporting the concept that management of acute and chronic inflammatory conditions including infections may modify risk for clonal expansion and subsequent malignancy (Binder et al., 2018; Mantovani et al., 2018).”
From Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling (2021) · cites this paper as Binder et al., 2018
Cites
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Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling
Hormaechea-Agulla, D., Matatall, K. A., Le, D. T., Kain, B., Long, X., Kus, P., Jaksik, R., Challen, G. A., Kimmel, M., & King, K. Y. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.002 · Cited by 329 · see citing works
- Authors
- Binder, S., Luciano, M., & Horejs-Hoeck, J.
- Affiliations
- University of Salzburg (AT)
- ORCID
- Horejs-Hoeck, Jutta
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 43
- Pages
- 8-15
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2889370655
- Cited by
- 190
- References
- 6
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 28 · 2023: 23 · 2022: 36 · 2021: 27 · 2020: 27 · 2019: 7
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- County of Salzburg
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- acute myeloid leukemia, cytokine network, inflammatory cytokines, anti-inflammatory cytokines, IL-1β, TNF-α, interleukin-6, TGF-beta, IL-10, tumor microenvironment, drug resistance, leukemia cell proliferation, inflammation
- MeSH terms
- Animals, Humans, T-Lymphocytes, Leukemia, Myeloid, Acute, Cytokines, Inflammation Mediators
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