Altered error-related brain activity in youth with major depression
Open accessAbstract
Depression is associated with impairments in cognitive control including action monitoring processes, which involve the detection and processing of erroneous responses in order to adjust behavior. Although numerous studies have reported altered error-related brain activity in depressed adults, relatively little is known about age-related changes in error-related brain activity in depressed youth. This study focuses on the error-related negativity (ERN), a negative deflection in the event-related potential (ERP) that is maximal approximately 50ms following errors. High-density ERPs were examined following responses on a flanker task in 24 youth diagnosed with MDD and 14 low-risk healthy controls (HC). Results indicate that compared to HC, MDD youth had significantly smaller ERN amplitudes and did not exhibit the normative increases in ERN amplitudes as a function of age. Also, ERN amplitudes were similar in depressed youth with and without comorbid anxiety. These results suggest that depressed youth exhibit different age-related changes in brain activity associated with action monitoring processes. Findings are discussed in terms of existing work on the neural correlates of action monitoring and depression and the need for longitudinal research studies investigating the development of neural systems underlying action monitoring in youth diagnosed with and at risk for depression.
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Studies using the Flanker task do not observe a significant difference in spatial selective attention performance between unmedicated major depressive disorder patients and healthy controls.
“More often than not, studies investigating spatial selective attention by using the Flanker task (identifying the direction of an arrow flanked by distracting arrows) do not observe a significant difference in performance between unmedicated MDD patients and healthy controls21,22.”
From Paying attention to attention in depression (2019) · cites this paper as [21]
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References 104 · Cited by 77
- Authors
- Ladouceur, C. D., Slifka, J. S., Dahl, R. E., Birmaher, B., Axelson, D. A., & Ryan, N. D.
- Affiliations
- University of Pittsburgh (US)
- University of California, Berkeley (US)
- Corresponding author
- Ladouceur, Cecile D.
- Venue
- Developmental Cognitive Neuroscience
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 2
- Issue
- 3
- Pages
- 351-362
- ISSN
- 1878-9293 (ISSN-L)
- PMC
- PMC3369189
- OpenAlex
- W2014033233
- Cited by
- 77
- References
- 104
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 1 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 4
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cognitive Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- Canadian Institutes for Health Research (CIHR)
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, adolescent depression, error-related negativity, action monitoring, cognitive control, age-related changes, flanker task, anxiety comorbidity, event-related potentials, neural correlates of depression
- MeSH terms
- Adolescent, Analysis of Variance, Brain, Brain Diseases, Child, Major Depressive Disorder, Electroencephalography, Evoked Potentials, Female, Humans, Male, Neuropsychological Tests, Photic Stimulation, Psychomotor Performance, Reaction Time, Case-Control Studies
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