Atypical lateralization of ERP response to native and non-native speech in infants at risk for autism spectrum disorder
Open accessAbstract
Language impairment is common in autism spectrum disorders (ASD) and is often accompanied by atypical neural lateralization. However, it is unclear when in development language impairment or atypical lateralization first emerges. To address these questions, we recorded event-related-potentials (ERPs) to native and non-native speech contrasts longitudinally in infants at risk for ASD (HRA) over the first year of life to determine whether atypical lateralization is present as an endophenotype early in development and whether these infants show delay in a very basic precursor of language acquisition: phonemic perceptual narrowing. ERP response for the HRA group to a non-native speech contrast revealed a trajectory of perceptual narrowing similar to a group of low-risk controls (LRC), suggesting that phonemic perceptual narrowing does not appear to be delayed in these high-risk infants. In contrast there were significant group differences in the development of lateralized ERP response to speech: between 6 and 12 months the LRC group displayed a lateralized response to the speech sounds, while the HRA group failed to display this pattern. We suggest the possibility that atypical lateralization to speech may be an ASD endophenotype over the first year of life.
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Infants at high risk for ASD, regardless of whether they ultimately meet diagnostic criteria for ASD, have different developmental trajectories within the first year of life compared to low-risk infants.
“There is now accumulating evidence from electroencephalographic (EEG) studies suggesting that infants at high risk for ASD, regardless of whether they ultimately meet diagnostic criteria for ASD, have different developmental trajectories within the first year of life compared to low-risk infants [10–20].”
From EEG power at 3 months in infants at high familial risk for autism (2017) · cites this paper as [18]
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References 64 · Cited by 84
- Authors
- Seery, A. M., Vogel-Farley, V., Tager-Flusberg, H., & Nelson, C. A.
- Affiliations
- Boston University (US)
- Boston Children's Hospital (US)
- Corresponding author
- Seery, Anne M.
- Venue
- Developmental Cognitive Neuroscience
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 5
- Pages
- 10-24
- ISSN
- 1878-9293 (ISSN-L)
- PMC
- PMC3676696
- OpenAlex
- W2034453622
- Cited by
- 84
- References
- 64
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 11 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 5 · 2013: 2
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cognitive Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIDCD (R21 DC 08637, R01 DC 10290)
- Simons Foundation (137186)
- Autism Speaks Pilot Grants Program
- Autism Speaks Dennis Weatherstone Predoctoral Fellowship Program
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- autism spectrum disorder, event-related potentials, speech perception, endophenotypes, language development, native vs non-native speech, longitudinal development
- MeSH terms
- Acoustic Stimulation, Child Development Disorders, Pervasive, Cross-Sectional Studies, Evoked Potentials, Auditory, Female, Follow-Up Studies, Humans, Infant, Functional Laterality, Longitudinal Studies, Male, Risk Factors, Speech, Endophenotypes
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