The DOI matches its Crossref record; 303 of the 303 references it cites were found in a registry or an index.
Immune signaling as a node of interaction between systems that sex-specifically develop during puberty and adolescence
Open accessAbstract
Adolescence is pivotal for neural and behavioral development across species. During this period, maturation occurs in several biological systems, the most well-recognized being activation of the hypothalamic-pituitary-gonadal axis marking pubertal onset. Increasing comparative studies of sex differences have enriched our understanding of systems integration during neurodevelopment. In recent years, immune signaling has emerged as a key node of interaction between a variety of biological signaling processes. Herein, we review the age- and sex-specific changes that occur in neural, hypothalamic-pituitary, and microbiome systems during adolescence. We then describe how immune signaling interacts with these systems, and review recent preclinical evidence indicating that immune signaling may play a central role in integrating changes in their typical and atypical development during adolescence. Finally, we discuss the translational relevance of these preclinical studies to human health and wellness.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“it is increasingly recognized to be evolutionarily conserved, with animal species also showing distinct markers of an adolescent state [35–40].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604
Brain development during childhood and adolescence: a longitudinal MRI study
Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., Paus, T., Evans, A. C., & Rapoport, J. L. (1999) · Nature Neuroscience · doi:10.1038/13158 · Cited by 5,552
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774
Cited by
Sorted by citations
Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice
Reynolds, L. M., Hernandez, G., MacGowan, D., Popescu, C., Nouel, D., Cuesta, S., Burke, S., Savell, K. E., Zhao, J., Restrepo-Lozano, J. M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39665-1 · Cited by 30
Reynolds, L. M., Faure, P., & Barik, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03110-0 · Cited by 26
Qiu, T., Li, X., Chen, W., He, J., Shi, L., Zhou, C., Zheng, A., Lei, Z., Tang, C., Yu, Q., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1132791 · Cited by 13
Petrican, R., Fornito, A., & Boyland, E. J. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.06.023 · Cited by 14
Adolescent social isolation induces sex-specific behavioral and neural alterations
Albanese, N. C., Poggini, S., Reccagni, A., Barezzi, C., Salciccia, C., Poleggi, A., & Branchi, I. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107264 · Cited by 10
An emerging view on vascular fibrosis molecular mediators and relevant disorders: from bench to bed
Hua, R., Gao, H., He, C., Xin, S., Wang, B., Zhang, S., Gao, L., Tao, Q., Wu, W., Sun, F., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1273502 · Cited by 10
Huang, H., Zhang, K. P., Sun, K. K., & Yu, G. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1292071 · Cited by 7
Petrican, R., Fornito, A., Murgatroyd, C., Boyland, E. J., & Hardman, C. A. (2025) · Nature Communications · doi:10.1038/s41467-025-60686-5 · Cited by 5
Ibouzine‐Dine, L., Berkiks, I., Mallouk, H., Lamtai, M., Marzouki, Z. E., Dimaoui, A., Mesfioui, A., & Hessni, A. E. (2024) · Advances in Animal and Veterinary Sciences · doi:10.17582/journal.aavs/2024/12.10.1976.1988 · Cited by 3
Petrican, R., Chopra, S., Segal, A., Fallon, N., & Fornito, A. (2025) · Nature Mental Health · doi:10.1038/s44220-024-00352-9 · Cited by 3
Duan, X., Tao, Y., Situ, M., Yu, X.-P., Jing, D., Liu, P., Yang, Z., & Huang, Y. (2025) · Depression and Anxiety · doi:10.1155/da/9546609 · Cited by 2
Feng, M., He, J., Wen, Q., Yao, J., Zeng, Y., Tan, Y., Li, H., Wang, Y., Wang, G., Dong, L., et al. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-07779-7 · Cited by 2
Williamson, V. G., Allen, N. B., & Pfeifer, J. H. (2026) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2026.06.010 · Cited by 2
Figueroa, C., Edgar, E. L., Kirkland, J. M., Patel, I., King’uyu, D. N., & Kopec, A. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.27.538622 · Cited by 1
Self-citationKirkland, J. M., Patel, I., & Kopec, A. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.02.539121 · Cited by 1
Self-citationNingrum, N. Y. S., Rasni, H., & Kurdi, F. (2025) · Journal of Rural Community Nursing Practice · doi:10.58545/jrcnp.v3i1.465
Metadata
- Authors
- Granata, L., Gildawie, K. R., Ismail, N., Brenhouse, H. C., & Kopec, A. M.
- Affiliations
- Northeastern University (US)
- Tufts University (US)
- University of Ottawa (CA)
- Albany Medical College (US)
- Corresponding author
- Kopec, Ashley M.
- Venue
- Developmental Cognitive Neuroscience
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 57
- Pages
- 101143
- ISSN
- 1878-9293 (ISSN-L)
- PMC
- PMC9357835
- OpenAlex
- W4289527871
- Cited by
- 15
- References
- 300
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 6
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Developmental Cognitive Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R03AG07011)
- Natural Sciences and Engineering Research Council of Canada
- National Institute on Aging (R03AG070111)
- National Institute of Mental Health (R01MH127850)
- National Institute on Drug Abuse (R01DA052889)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- immune signaling, adolescence, puberty, sex differences, hypothalamic-pituitary-gonadal axis, microbiome, brain development, system integration, hypothalamic-pituitary axis, atypical development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
