The Role of Systemic Retinoids in the Treatment of Cutaneous T-Cell Lymphoma
Open accessAbstract
Retinoids are natural and synthetic vitamin A analogs with effects on cell proliferation, differentiation, and apoptosis. They have significant activity in hematologic malignancies and have been studied extensively in cutaneous T-cell lymphoma. Retinoids bind to nuclear receptors and exert their effects through moderation of gene expression. Retinoic acid receptor and retinoic X receptor exert regulatory activity in vivo, binding to distinct ligands. Studies investigating systemic retinoids as monotherapy and in combination with other agents active against cutaneous lymphoma are reviewed. Side effects associated with retinoids include teratogenicity, dyslipidemias, and hypothyroidism, which should be carefully monitored in patients receiving treatment.
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High levels of serum aminotransferase and liver injury have been reported with bexarotene.
“However, high levels of serum aminotransferase and liver injury have been reported32.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [32]
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References 76 · Cited by 52
- Authors
- Huen, A. O., & Kim, E. J.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Kim, Ellen J.
- Venue
- Dermatologic Clinics
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 33
- Issue
- 4
- Pages
- 715-729
- ISSN
- 0733-8635 (ISSN-L)
- OpenAlex
- W1649707569
- Cited by
- 52
- References
- 76
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 3
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-07-01)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Dermatologic Clinics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- systemic retinoids, cutaneous T-cell lymphoma, vitamin A analogs, retinoic acid receptor, retinoid X receptor, nuclear receptors, combination therapy, teratogenicity, dyslipidemia, hypothyroidism, adverse effects
- MeSH terms
- Bexarotene, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Combined Modality Therapy, Humans, Hyperlipidemias, Hypothyroidism, Immunologic Factors, Interferons, Mycosis Fungoides, PUVA Therapy, Retinoids, Sezary Syndrome, Skin Neoplasms, Tetrahydronaphthalenes
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