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Cited by 367Axon Guidance and Neuronal SignalingAngiogenesis and VEGF in CancerDevelopmental Biology and Gene Regulation

Semaphorin-Plexin Signaling Guides Patterning of the Developing Vasculature

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Torres-Vázquez, Jesús, Gitler, Aaron D, Fraser, Sherri D, Berk, Jason D, Van N. Pham, Fishman, Mark C, Childs, Sarah, Epstein, Jonathan A +1 more·2004·Developmental Cell
DOI 10.1016/j.devcel.2004.06.008
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Abstract

Major vessels of the vertebrate circulatory system display evolutionarily conserved and reproducible anatomy, but the cues guiding this stereotypic patterning remain obscure. In the nervous system, axonal pathways are shaped by repulsive cues provided by ligands of the semaphorin family that are sensed by migrating neuronal growth cones through plexin receptors. We show that proper blood vessel pathfinding requires the endothelial receptor PlexinD1 and semaphorin signals, and we identify mutations in plexinD1 in the zebrafish vascular patterning mutant out of bounds. These results reveal the fundamental conservation of repulsive patterning mechanisms between axonal migration in the central nervous system and vascular endothelium during angiogenesis.

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  • Neural guidance molecules such as netrins and semaphorins also shape the growing cerebrovasculature and BBB functions.

    “and neural guidance molecules such as netrins and semaphorins also shape the growing cerebrovasculature and BBB functions (22, 475, 596, 628).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [596]

    The Introduction (page unavailable) reports that semaphorin–plexin signaling patterns developing zebrafish intersegmental vessels. It does not establish a role for netrins, specifically cerebrovascular development, or blood–brain barrier functions. (LLM, conf=0.88)

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References 31 · Cited by 367

Research works printed but not linked: 28

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Authors
Torres-Vázquez, J., Gitler, A. D., Fraser, S. D., Berk, J. D., Pham, V. N., Fishman, M. C., Childs, S., Epstein, J. A., & Weinstein, B. M.
Affiliations
  • University of Pennsylvania (US)
  • University of Calgary (CA)
  • National Institutes of Health (US)
  • Massachusetts General Hospital (US)
ORCID
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2004-07
Volume
7
Issue
1
Pages
117-123
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2004.06.008
OpenAlex
W2014562769
Cited by
367
References
31
Citations by year
2026: 8 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 13 · 2021: 10 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 24 · 2016: 12 · 2015: 20 · 2014: 15 · 2013: 23 · 2012: 16
FWCI
11.62
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
Damon Runyon Cancer Research Foundation
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
semaphorin signaling, PlexinD1, vascular patterning, endothelial cells, angiogenesis, zebrafish, repulsive guidance cues, axon guidance, growth cones, vascular development
MeSH terms
Animals, Blood Vessels, Cell Line, Humans, Membrane Glycoproteins, Molecular Sequence Data, Mutation, Nerve Tissue Proteins, Receptors, Cell Surface, Zebrafish, Signal Transduction, Gene Expression Regulation, Developmental, Neovascularization, Physiologic, Somites, Body Patterning, Zebrafish Proteins, Semaphorins, Intracellular Signaling Peptides and Proteins, Mice

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