The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Interplay of Pu.1 and Gata1 Determines Myelo-Erythroid Progenitor Cell Fate in Zebrafish
Open accessAbstract
The zebrafish is a powerful model system for investigating embryonic vertebrate hematopoiesis, allowing for the critical in vivo analysis of cell lineage determination. In this study, we identify zebrafish myeloerythroid progenitor cells (MPCs) that are likely to represent the functional equivalent of mammalian common myeloid progenitors. Utilizing transgenic pu.1-GFP fish, real-time MPC differentiation was correlated with dynamic changes in cell motility, morphology, and gene expression. Unlike mammalian hematopoiesis, embryonic zebrafish myelopoiesis and erythropoiesis occur in anatomically separate locations. Gene knockdown experiments and transplantation assays demonstrated the reciprocal negative regulation of pu.1 and gata1 and their non-cell-autonomous regulation that determines myeloid versus erythroid MPC fate in the distinct blood-forming regions. Furthermore, forced expression of pu.1 in the bloodless mutant cloche resulted in myelopoietic rescue, providing intriguing evidence that this gene can function in the absence of some stem cell genes, such as scl, in governing myelopoiesis.
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Cites
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617
Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308
PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors
Nerlov, C., & Graf, T. (1998) · Genes & Development · doi:10.1101/gad.12.15.2403 · Cited by 449 · cited 2×
“1 can drive myeloid differentiation by MPCs Require Gata1 for Erythroid Cell Differentiation downregulating gata1 (Kulessa et al., 1995; Nerlov and Graf, 1998).”
BackgroundMethodKulessa, H., Frampton, J., & Graf, T. (1995) · Genes & Development · doi:10.1101/gad.9.10.1250 · Cited by 418
Cited by
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570
Forcing cells to change lineages
Graf, T., & Enver, T. (2009) · Nature · doi:10.1038/nature08533 · Cited by 899
Peri, F., & Nüsslein-Volhard, C. (2008) · Cell · doi:10.1016/j.cell.2008.04.037 · Cited by 617
Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence
Espín-Palazón, R., Stachura, D. L., Campbell, C. A., García-Moreno, D., Del Cid, N., Kim, A. D., Candel, S., Meseguer, J., Mulero, V., & Traver, D. (2014) · Cell · doi:10.1016/j.cell.2014.10.031 · Cited by 333
Loss of Gata1 but Not Gata2 Converts Erythropoiesis to Myelopoiesis in Zebrafish Embryos
Galloway, J. L., Wingert, R. A., Thisse, C., Thisse, B., & Zon, L. I. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.12.001 · Cited by 242
Metadata
- Authors
- Rhodes, J., Hagen, A., Hsu, K., Deng, M., Liu, T. X., Look, A. T., & Kanki, J. P.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 8
- Issue
- 1
- Pages
- 97-108
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2055004906
- Cited by
- 353
- References
- 4
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rhodes, J., Hagen, A., Hsu, K., Deng, M., Liu, T. X., Look, A. T., & Kanki, J. P. (2005). Interplay of Pu.1 and Gata1 Determines Myelo-Erythroid Progenitor Cell Fate in Zebrafish. Developmental Cell. https://doi.org/10.1016/j.devcel.2004.11.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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