Genomic Regulatory Networks and Animal Development
Open accessAbstract
The synthesis of gene expression data and cis-regulatory analysis permits the elucidation of genomic regulatory networks. These networks provide a direct visualization of the functional interconnections among the regulatory genes and signaling components leading to cell-specific patterns of gene activity. Complex developmental processes are thereby illuminated in ways not revealed by the conventional analysis of individual genes. In this review, we describe emerging networks in several different model systems, and compare them with the gene regulatory network that controls dorsoventral patterning of the Drosophila embryo.
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The Drosophila dorsal/ventral patterning GRN has extensive cis-regulatory support and is hierarchical, with unusual structure reflecting the syncytial developmental process.
“The GRN for dorsal/ventral patterning in Drosophila14, which does have extensive cis-regulatory support, is also hierarchical, but its unusual structure reflects the unusual developmental process it controls.”
From Emerging properties of animal gene regulatory networks (2010) · cites this paper as [14]
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References 126 · Cited by 223
- Authors
- Stathopoulos, A., & Levine, M.
- Affiliations
- California Institute of Technology (US)
- University of California, Berkeley (US)
- Corresponding author
- Stathopoulos, Angelike
- Levine, Michael
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 9
- Issue
- 4
- Pages
- 449-462
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1969499963
- Cited by
- 223
- References
- 126
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 15 · 2015: 13 · 2014: 8 · 2013: 9 · 2012: 14
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2882 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institutes of Health (GM46638)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- gene regulatory networks, animal development, cis-regulatory elements, gene expression, signaling pathways, Drosophila embryo, dorsoventral patterning, model organisms
- MeSH terms
- Animals, Cell Differentiation, Embryo, Mammalian, Embryo, Nonmammalian, Models, Genetic, Morphogenesis, Regulatory Sequences, Nucleic Acid, Signal Transduction, Genes, Reporter, Gene Expression Regulation, Developmental, Cell Lineage, Body Patterning, Animals, Genetically Modified
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