The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cell-Type-Specific TEV Protease Cleavage Reveals Cohesin Functions in Drosophila Neurons
Open accessAbstract
Cohesin is a highly conserved multisubunit complex that holds sister chromatids together in mitotic cells. At the metaphase to anaphase transition, proteolytic cleavage of the alpha kleisin subunit (Rad21) by separase causes cohesin's dissociation from chromosomes and triggers sister-chromatid disjunction. To investigate cohesin's function in postmitotic cells, where it is widely expressed, we have created fruit flies whose Rad21 can be cleaved by TEV protease. Cleavage causes precocious separation of sister chromatids and massive chromosome missegregation in proliferating cells, but not disaggregation of polytene chromosomes in salivary glands. Crucially, cleavage in postmitotic neurons is lethal. In mushroom-body neurons, it causes defects in axon pruning, whereas in cholinergic neurons it causes highly abnormal larval locomotion. These data demonstrate essential roles for cohesin in nondividing cells and also introduce a powerful tool by which to investigate protein function in metazoa.
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Cites
Krantz, I. D., McCallum, J., DeScipio, C., Kaur, M., Gillis, L. A., Yaeger, D., Jukofsky, L., Wasserman, N., Bottani, A., Morris, C. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1364 · Cited by 713
Wapl controls the dynamic association of cohesin with chromatin
Kueng, S., Hegemann, B., Peters, B. H., Lipp, J. J., Schleiffer, A., Mechtler, K., & Peters, J.-M. (2006) · Cell · doi:10.1016/j.cell.2006.09.040 · Cited by 624
Cited by
Wutz, G., Várnai, C., Nagasaka, K., Cisneros, D. A., Stocsits, R. R., Tang, W., Schoenfelder, S., Jessberger, G., Muhar, M., Hossain, M. J., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201798004 · Cited by 864
Enhancer function: new insights into the regulation of tissue-specific gene expression
Ong, C.-T., & Corces, V. G. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2957 · Cited by 929
Comparative Hi-C Reveals that CTCF Underlies Evolution of Chromosomal Domain Architecture
Vietri Rudan, M., Barrington, C., Henderson, S., Ernst, C., Odom, D. T., Tanay, A., & Hadjur, S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.004 · Cited by 680
“…activity of CTCF depends on cohesin (Parelho et al., 2008; Wendt et al., 2008), an essential protein complex required for sister chromatid cohesion during mitosis (Michaelis et al., 1997; Guacci et al., 1997), which also functions in gene regulation (Rollins et al., 1999; Pauli et al., 2008).”
Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells
Zuin, J., Dixon, J. R., van der Reijden, M. I. J. A., Ye, Z., Kolovos, P., Brouwer, R. W. W., van de Corput, M. P. C., van de Werken, H. J. G., Knoch, T. A., van IJcken, W. F. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317788111 · Cited by 779
The cohesin ring concatenates sister DNA molecules
Haering, C. H., Farcas, A.-M., Arumugam, P., Metson, J., & Nasmyth, K. (2008) · Nature · doi:10.1038/nature07098 · Cited by 494
Self-citation
Metadata
- Authors
- Pauli, A., Althoff, F., Oliveira, R. A., Heidmann, S., Schuldiner, O., Lehner, C. F., Dickson, B. J., & Nasmyth, K.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 14
- Issue
- 2
- Pages
- 239-251
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1983579777
- Cited by
- 283
- References
- 2
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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