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A Subcortical Maternal Complex Essential for Preimplantation Mouse Embryogenesis
Open accessAbstract
SUMMARY We have identified a subcortical maternal complex (SCMC) that assembles during oocyte growth and is essential for zygotes to progress beyond the first embryonic cell divisions. At least four maternally encoded proteins contribute to this MDa complex: FLOPED, MATER and TLE6 interact with each other while Filia binds independently to MATER. Although the transcripts encoding these proteins are degraded during meiotic maturation and ovulation, the SCMC proteins persist in the early embryo. The SCMC, located in the subcortex of eggs, is excluded from regions of cell-cell contact in the cleavage-stage embryo and segregates to the outer cells of the morulae and blastocyst. Flopedtm/tm and/or Matertm/tm eggs lack the SCMC, but can be fertilized. However, these embryos do not progress beyond cleavage stage development and female mice are sterile. The proteins are conserved in humans and similar maternal effect mutations may result in recurrent embryonic loss.
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Cited by
Maternal control of early mouse development
Li, L., Zheng, P., & Dean, J. (2010) · Development · doi:10.1242/dev.039487 · Cited by 481
Self-citationDynamics of the epigenetic landscape during the maternal-to-zygotic transition
Eckersley-Maslin, M. A., Alda-Catalinas, C., & Reik, W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0008-z · Cited by 431
(2019) · doi:10.1038/s41598-019-49817-3 · Cited by 52
Metadata
- Authors
- Li, L., Baibakov, B., & Dean, J.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 15
- Issue
- 3
- Pages
- 416-425
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2089536182
- Cited by
- 326
- References
- 0
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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