The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling
Open accessAbstract
Summary Growth and expansion of ventricular chambers is essential during heart development and is achieved by proliferation of cardiac progenitors. Adult cardiomyocytes, by contrast, achieve growth through hypertrophy rather than hyperplasia. Although epicardial-derived signals may contribute to the proliferative process in myocytes, the factors and cell types responsible for development of the ventricular myocardial thickness are unclear. Using a co-culture system, we found that embryonic cardiac fibroblasts induced proliferation of cardiomyocytes, in contrast to adult cardiac fibroblasts that promoted myocyte hypertrophy. We identified fibronectin, collagen and heparin-binding EGF-like growth factor as embryonic cardiac fibroblast-specific signals that collaboratively promoted cardiomyocyte proliferation in a paracrine fashion. β1-integrin was required for this proliferative response, and ventricular cardiomyocyte-specific deletion of β1-integrin in mice resulted in reduced myocardial proliferation and impaired ventricular compaction. These findings reveal a previously unrecognized paracrine function of embryonic cardiac fibroblasts in regulating cardiomyocyte proliferation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538
Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Weber, K. T., & Brilla, C. G. (1991) · Circulation · doi:10.1161/01.cir.83.6.1849 · Cited by 2,027
Feeder-free growth of undifferentiated human embryonic stem cells
Xu, C., Inokuma, M. S., Denham, J., Golds, K., Kundu, P., Gold, J. D., & Carpenter, M. K. (2001) · Nature Biotechnology · doi:10.1038/nbt1001-971 · Cited by 1,870
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
Laugwitz, K.-L., Moretti, A., Lam, J., Gruber, P., Chen, Y., Woodard, S., Lin, L.-Z., Cai, C.-L., Lu, M. M., Reth, M., et al. (2005) · Nature · doi:10.1038/nature03215 · Cited by 1,304
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R., et al. (2008) · Nature · doi:10.1038/nature07060 · Cited by 1,019
Structural and functional characterisation of cardiac fibroblasts
CAMELLITI, P., BORG, T., & KOHL, P. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.020 · Cited by 930
A myocardial lineage derives from Tbx18 epicardial cells
Cai, C.-L., Martin, J. C., Sun, Y., Cui, L., Wang, L., Ouyang, K., Yang, L., Bu, L., Liang, X., Zhang, X., et al. (2008) · Nature · doi:10.1038/nature06969 · Cited by 784
Cited by
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
Ieda, M., Fu, J.-D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., & Srivastava, D. (2010) · Cell · doi:10.1016/j.cell.2010.07.002 · Cited by 2,454
Self-citationCardiac Fibrosis: The Fibroblast Awakens
Travers, J. G., Kamal, F. A., Robbins, J., Yutzey, K. E., & Blaxall, B. C. (2016) · Circulation Research · doi:10.1161/circresaha.115.306565 · Cited by 1,596
Single-Cell Resolution of Temporal Gene Expression during Heart Development
DeLaughter, D. M., Bick, A. G., Wakimoto, H., McKean, D., Gorham, J. M., Kathiriya, I. S., Hinson, J. T., Homsy, J., Gray, J., Pu, W., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.10.001 · Cited by 423
Smith, C. L., Baek, S. T., Sung, C. Y., & Tallquist, M. D. (2011) · Circulation Research · doi:10.1161/circresaha.110.235531 · Cited by 339
Wessels, A., van den Hoff, M. J. B., Adamo, R. F., Phelps, A. L., Lockhart, M. M., Sauls, K., Briggs, L. E., Norris, R. A., van Wijk, B., Perez-Pomares, J. M., et al. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.04.020 · Cited by 263
Zhang, J., Tao, R., Campbell, K. F., Carvalho, J. L., Ruiz, E. C., Kim, G. C., Schmuck, E. G., Raval, A. N., da Rocha, A. M., Herron, T. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09831-5 · Cited by 201
Majkut, S., Idema, T., Swift, J., Krieger, C., Liu, A., & Discher, D. E. (2013) · Current Biology · doi:10.1016/j.cub.2013.10.057 · Cited by 198
Development of a human cardiac organoid injury model reveals innate regenerative potential
Voges, H. K., Mills, R. J., Elliott, D. A., Parton, R. G., Porrello, E. R., & Hudson, J. E. (2017) · Development · doi:10.1242/dev.143966 · Cited by 196
Bargehr, J., Ong, L. P., Colzani, M., Davaapil, H., Hofsteen, P., Bhandari, S., Gambardella, L., Le Novère, N., Iyer, D., Sampaziotis, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0197-9 · Cited by 195
Cardiovascular organ-on-a-chip platforms for drug discovery and development
Ribas, J., Sadeghi, H., Manbachi, A., Leijten, J., Brinegar, K., Zhang, Y. S., Ferreira, L., & Khademhosseini, A. (2016) · Applied In Vitro Toxicology · doi:10.1089/aivt.2016.0002 · Cited by 161
Das, S., Kim, S.-W., Choi, Y.-J., Lee, S., Lee, S.-H., Kong, J.-S., Park, H.-J., Cho, D.-W., & Jang, J. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.04.026 · Cited by 150
View from the heart: cardiac fibroblasts in development, scarring and regeneration
Furtado, M. B., Nim, H. T., Boyd, S. E., & Rosenthal, N. A. (2016) · Development · doi:10.1242/dev.120576 · Cited by 144
Origins of cardiac fibroblasts
Moore-Morris, T., Cattaneo, P., Puceat, M., & Evans, S. M. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.031 · Cited by 139
Origin, development, and differentiation of cardiac fibroblasts
Lajiness, J. D., & Conway, S. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.11.003 · Cited by 130
Mechanobiology of myofibroblast adhesion in fibrotic cardiac disease
Schroer, A. K., & Merryman, W. D. (2015) · Journal of Cell Science · doi:10.1242/jcs.162891 · Cited by 127
Sullivan, K. E., Quinn, K. P., Tang, K. M., Georgakoudi, I., & Black, L. D. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt403 · Cited by 117
Cardiac fibroblasts: more than mechanical support
Doppler, S. A., Carvalho, C., Lahm, H., Deutsch, M.-A., Dreßen, M., Puluca, N., Lange, R., & Krane, M. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.03.122 · Cited by 86
Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts
Hortells, L., Johansen, A. K. Z., & Yutzey, K. E. (2019) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd6030029 · Cited by 79
Devalla, H. D., & Passier, R. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aah5457 · Cited by 75
Fibronectin mediates mesendodermal cell fate decisions
Cheng, P., Andersen, P., Hassel, D., Kaynak, B. L., Limphong, P., Juergensen, L., Kwon, C., & Srivastava, D. (2013) · Development · doi:10.1242/dev.089052 · Cited by 65
Self-citationKim, T. Y., Kofron, C. M., King, M. E., Markes, A. R., Okundaye, A. O., Qu, Z., Mende, U., & Choi, B.-R. (2018) · PLOS ONE · doi:10.1371/journal.pone.0196714 · Cited by 57
Metadata
- Authors
- Ieda, M., Tsuchihashi, T., Ivey, K. N., Ross, R. S., Hong, T.-T., Shaw, R. M., & Srivastava, D.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 16
- Issue
- 2
- Pages
- 233-244
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2118221757
- Cited by
- 580
- References
- 41
- FWCI
- 12.72
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
