The Role of Hypoxia in Development of the Mammalian Embryo
Open accessAbstract
Hypoxia inducible factor (HIF) is a transcription factor that acts in low-oxygen conditions. The cellular response to HIF activation is transcriptional upregulation of a large group of genes. Some target genes promote anaerobic metabolism to reduce oxygen consumption, while others "alleviate" hypoxia by acting non-cell-autonomously to extend and modify the surrounding vasculature. Although hypoxia is often thought of as being a pathological phenomenon, the mammalian embryo in fact develops in a low-oxygen environment, and in this context HIF has additional responsibilities. This review describes how low oxygen and HIF affect gene expression, cell behavior, and ultimately morphogenesis of the embryo and placenta.
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HIF signaling is essential for development and tissue homeostasis.
“While HIF signaling is essential for development and tissue homeostasis”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [28]
Knockout of HIFs in mice results in failure of allantoic attachment with the chorion, impaired vascularization in the labyrinth, and abnormal differentiation of the trophoblast subpopulations.
“Knockout in mice results in failure of allantoic attachment with the chorion, impaired vascularization in the labyrinth, and abnormal differentiation of the trophoblast subpopulations (161).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [161]
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References 126 · Cited by 651
- Authors
- Dunwoodie, S. L.
- Affiliations
- Victor Chang Cardiac Research Institute (AU)
- Corresponding author
- Dunwoodie, Sally L.
- ORCID
- Dunwoodie, Sally L.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 17
- Issue
- 6
- Pages
- 755-773
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2064178384
- Semantic Scholar
- 7f3c91eefbeb062312d0d9cc4940c14b7675aab9
- Cited by
- 651
- References
- 126
- Citations by year
- 2026: 22 · 2025: 45 · 2024: 33 · 2023: 56 · 2022: 73 · 2021: 56 · 2020: 47 · 2019: 52 · 2018: 20 · 2017: 33 · 2016: 39 · 2015: 30 · 2014: 39 · 2013: 27 · 2012: 37
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- hypoxia, hypoxia-inducible factor, mammalian embryos, placenta, transcriptional regulation, anaerobic metabolism, vascular system, morphogenesis, gene expression
- MeSH terms
- Animals, Hypoxia, Embryo, Mammalian, Oxygen, Mice, Hypoxia-Inducible Factor 1
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