Neuronal regulation of the spatial patterning of neurogenesis
Open accessAbstract
Precise regulation of neurogenesis is achieved in specific regions of the vertebrate nervous system by formation of distinct neurogenic and nonneurogenic zones. We have investigated how neurogenesis becomes confined to zones adjacent to rhombomere boundaries in the zebrafish hindbrain. The nonneurogenic zone at segment centers comprises a distinct progenitor population that expresses fibroblast growth factor (fgfr) 2, erm, sox9b, and the retinoic acid degrading enzyme, cyp26b1. FGF receptor activation upregulates expression of these genes and inhibits neurogenesis in segment centers. Cyp26 activity is a key effector inhibiting neuronal differentiation, suggesting antagonistic interactions with retinoid signaling. We identify the critical FGF ligand, fgf20a, which is expressed by specific neurons located in the mantle region at the center of segments, adjacent to the nonneurogenic zone. Fgf20a mutants have ectopic neurogenesis and lack the segment center progenitor population. Our findings reveal how signaling from neurons induces formation of a nonneurogenic zone of neural progenitors.
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The authors observed expression of FGF ligands in multiple neuronal subtypes, whereas neural progenitors at later stages upregulated Fgfr3 and Fgfbp3.
“Lastly, we observed the expression of FGF ligands in multiple neuronal subtypes, whereas neural progenitors at later stages upregulated FGF receptor3 (Fgfr3) and FGF-binding protein 3 (Fgfbp3) (Gonzalez-Quevedo et al., 2010; Kang et al., 2012).”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Gonzalez-Quevedo et al., 2010
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References 72 · Cited by 75
Research works printed but not linked: 1
- Xu Q Wilkinson DG Wilkinson D In situ hybridisation of mRNA with hapten labelled probes In situ hybridisation: A practical approach 1998 Oxford Oxford University Press 87 106
- Authors
- Gonzalez-Quevedo, R., Lee, Y., Poss, K. D., & Wilkinson, D. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- National Institute for Medical Research (GB)
- Corresponding author
- Wilkinson, David G.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 18
- Issue
- 1
- Pages
- 136-147
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC2822724
- OpenAlex
- W2023826146
- Cited by
- 75
- References
- 72
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pew Charitable Trusts
- National Institutes of Health
- Medical Research Council
- National Heart, Lung, and Blood Institute (R01HL081674)
- National Institute of General Medical Sciences (R01GM074057)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- neurogenesis, spatial patterning, FGF receptor 2, CYP26B1, retinoic acid signaling, neuronal regulation, neural progenitor cells, sox9b, ERM
- MeSH terms
- Retinoic Acid 4-Hydroxylase, Animals, Cell Communication, Cytochrome P-450 Enzyme System, DNA-Binding Proteins, Fibroblast Growth Factors, Neurons, Rhombencephalon, Stem Cells, Transcription Factors, Zebrafish, Signal Transduction, Fibroblast Growth Factor 2, Gene Expression Regulation, Developmental, Body Patterning, Zebrafish Proteins, Neurogenesis, SOX9 Transcription Factor
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