The origin of digits: Expression patterns versus regulatory mechanisms
Open accessAbstract
In the emerging discipline of Evo-Devo, the analysis of gene expression patterns can be deceptive without a clear understanding of the underlying regulatory strategies. Here, we use the paradigm of hand and foot evolution to argue that the consideration of the regulatory mechanisms controlling developmental gene expression is essential to resolve comparative conundrums. In this context, we discuss the adaptive relevance of evolving stepwise, distinct developmental regulatory mechanisms to build an arm, i.e., a composite structure with functional coherence.
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Some limb-specific elements of the GCR likely evolved in tetrapods, particularly the autopod control device and its patterning GRN, making the autopod a novel evolutionary invention relative to fish antecedents.
“some limb specific elements of the GCR likely evolved in tetrapods, particularly the autopod control device and its patterning GRN, which would make the autopod a novel evolutionary invention with respect to the fish antecedents (Gonzalez et al., 2007; Woltering and Duboule, 2010).”
From Evolution of Gene Regulatory Networks Controlling Body Plan Development (2011) · cites this paper as Woltering and Duboule, 2010
Cites
Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene
Prud'homme, B., Gompel, N., Rokas, A., Kassner, V. A., Williams, T. M., Yeh, S.-D., True, J. R., & Carroll, S. B. (2006) · Nature · doi:10.1038/nature04597 · Cited by 507 · see citing works
Control of Hoxd genes' collinearity during early limb development
Tarchini, B., & Duboule, D. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.11.014 · Cited by 222 · see citing works
Self-citationTransgenic analysis of Hoxd gene regulation during digit development
Gonzalez, F., Duboule, D., & Spitz, F. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.020 · Cited by 107 · see citing works
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Evolution of Gene Regulatory Networks Controlling Body Plan Development
Peter, I. S., & Davidson, E. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.017 · Cited by 417 · see citing works
- Authors
- Woltering, J. M., & Duboule, D.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Duboule, Denis
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 18
- Issue
- 4
- Pages
- 526-532
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1989907054
- Cited by
- 125
- References
- 3
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 16 · 2016: 15 · 2015: 6 · 2014: 9 · 2013: 14 · 2012: 14
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1203 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- École Polytechnique Fédérale de Lausanne
- EMBO
- European Commission
- Université de Genève
- European Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Congenital limb and hand anomalies
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Keywords
- hand evolution, foot evolution, gene expression patterns, developmental gene regulation, evolutionary developmental biology, composite structures, limb development, regulatory mechanisms
- MeSH terms
- Animals, Chickens, Biological Evolution, Extremities, Fishes, Models, Biological, Models, Genetic, Developmental Biology, Protein Structure, Tertiary, Homeodomain Proteins, Gene Expression Regulation, Developmental, Gene Expression Profiling
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