The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Transcriptional Dominance of Pax7 in Adult Myogenesis Is Due to High-Affinity Recognition of Homeodomain Motifs
Open accessAbstract
SUMMARY Pax3 and Pax7 regulate stem cell function in skeletal myogenesis. However, molecular insight into their distinct roles has remained elusive. Using gene expression data combined with genome wide binding-site analysis we show that both Pax3 and Pax7 bind identical DNA motifs and jointly activate a large panel of genes involved in muscle stem cell function. Surprisingly, in adult myoblasts Pax3 binds a subset (6.4%) of Pax7 targets. Despite a significant overlap in their transcriptional network, Pax7 regulates distinct panels of genes involved in the promotion of proliferation and inhibition of myogenic differentiation. We show that Pax7 has a higher binding affinity to the homeodomain-binding motif relative to Pax3, suggesting that intrinsic differences in DNA binding contribute to the observed functional difference between Pax3 and Pax7 binding in myogenesis. Together, our data demonstrates distinct attributes of Pax7 function and provides mechanistic insight into the non-redundancy of Pax3 and Pax7 in muscle development.
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
GREAT improves functional interpretation of cis-regulatory regions
McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., Wenger, A. M., & Bejerano, G. (2010) · Nature Biotechnology · doi:10.1038/nbt.1630 · Cited by 4,502
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449 · cited 4×
“Conversely, Pax7 alone is essential for satellite cells up to a critical postnatal period (Kuang et al., 2007; Lepper et al., 2009; Oustanina et al., 2004; Relaix et al., 2006; Seale et al., 2000).”
BackgroundInfluentialSelf-citationPax7 activates myogenic genes by recruitment of a histone methyltransferase complex
McKinnell, I. W., Ishibashi, J., Le Grand, F., Punch, V. G. J., Addicks, G. C., Greenblatt, J. F., Dilworth, F. J., & Rudnicki, M. A. (2008) · Nature Cell Biology · doi:10.1038/ncb1671 · Cited by 380 · cited 3×
“We have previously shown that the presence of C-terminal TAP tag does not interfere with Pax7 function (McKinnell et al., 2008).”
BackgroundSelf-citationP38-γ–dependent gene silencing restricts entry into the myogenic differentiation program
Gillespie, M. A., Le Grand, F., Scimè, A., Kuang, S., von Maltzahn, J., Seale, V., Cuenda, A., Ranish, J. A., & Rudnicki, M. A. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907037 · Cited by 131 · cited 1×
“Reverse cross-linking and phenol/chloroform extraction of chromatin were done as described previously (Gillespie et al., 2009).”
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Cited by
Satellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719
Self-citationGene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis
Buckingham, M., & Rigby, P. W. J. (2014) · Developmental Cell · doi:10.1016/j.devcel.2013.12.020 · Cited by 667
Self-citationPax7 is critical for the normal function of satellite cells in adult skeletal muscle
von Maltzahn, J., Jones, A. E., Parks, R. J., & Rudnicki, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307680110 · Cited by 602
Self-citationGünther, S., Kim, J., Kostin, S., Lepper, C., Fan, C.-M., & Braun, T. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.07.016 · Cited by 280
Soleimani, V. D., Yin, H., Jahani-Asl, A., Ming, H., Kockx, C. E. M., van Ijcken, W. F. J., Grosveld, F., & Rudnicki, M. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.046 · Cited by 200
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Metadata
- Authors
- Soleimani, V. D., Punch, V. G., Kawabe, Y.-I., Jones, A. E., Palidwor, G. A., Porter, C. J., Cross, J. W., Carvajal, J. J., Kockx, C. E. M., van IJcken, W. F. J., Perkins, T. J., Rigby, P. W. J., Grosveld, F., & Rudnicki, M. A.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 22
- Issue
- 6
- Pages
- 1208-1220
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2072361742
- Cited by
- 191
- References
- 5
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Soleimani, V. D., Punch, V. G., Kawabe, Y.-I., Jones, A. E., Palidwor, G. A., Porter, C. J., Cross, J. W., Carvajal, J. J., Kockx, C. E. M., van IJcken, W. F. J., Perkins, T. J., Rigby, P. W. J., Grosveld, F., & Rudnicki, M. A. (2012). Transcriptional Dominance of Pax7 in Adult Myogenesis Is Due to High-Affinity Recognition of Homeodomain Motifs. Developmental Cell. https://doi.org/10.1016/j.devcel.2012.03.014
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