The Ecdysone Receptor Coactivator Taiman Links Yorkie to Transcriptional Control of Germline Stem Cell Factors in Somatic Tissue
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The Hippo pathway is a conserved signaling cascade that modulates tissue growth. Although its core elements are well defined, factors modulating Hippo transcriptional outputs remain elusive. Here we show that components of the steroid-responsive ecdysone (Ec) pathway modulate Hippo transcriptional effects in imaginal disc cells. The Ec receptor coactivator Taiman (Tai) interacts with the Hippo transcriptional coactivator Yorkie (Yki) and promotes expression of canonical Yki-responsive genes. Tai enhances Yki-driven growth, while Tai loss, or a form of Tai unable to bind Yki, suppresses Yki-driven tissue growth. This growth suppression is not correlated with impaired induction of canonical Hippo-responsive genes but with suppression of a distinct pro-growth program of Yki-induced/Tai-dependent genes, including the germline stem cell factors nanos and piwi. These data reveal Hippo/Ec pathway crosstalk in the form a Yki-Tai complex that collaboratively induces germline genes as part of a transcriptional program that is normally repressed in developing somatic epithelia.
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Yki can form transcriptional complexes that cooperatively alter gene expression in cancer cells.
“Similarly, Yki can form transcriptional complexes that cooperatively alter gene expression in cancer cells, for example, Yki and the Ecdysone receptor coactivator Taiman were shown to alter transcriptional output of Yki inducible Taiman dependent genes in cells with hyperactive Yki, and neoplastic tumour growth (77).”
From A Tumour-Specific Molecular Network Promotes Tumour Growth in <i>Drosophila</i> by Enforcing a JNK-YKI Feedforward Loop (2023) · cites this paper as [77]
The Introduction and Discussion report that Yki and Tai interact and that Tai changes the transcriptional output of hyperactive Yki, including genes associated with tissue overgrowth. The experiments described in the Results use developing fly imaginal-disc cells, not cancer cells; the paper does not establish the claimed effect in cancer cells. (LLM, conf=0.87)
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References 78 · Cited by 70
Research works printed but not linked: 1
- Gaziova I Bonnette PC Henrich VC Jindra M 2004 Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis Development 131 2715 2725 15128659
- Authors
- Zhang, C., Robinson, B. S., Xu, W., Yang, L., Yao, B., Zhao, H., Byun, P. K., Jin, P., Veraksa, A., & Moberg, K. H.
- Affiliations
- Emory University (US)
- University of Massachusetts Boston (US)
- Corresponding author
- Moberg, Kenneth H.
- ORCID
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 34
- Issue
- 2
- Pages
- 168-180
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC4519380
- OpenAlex
- W1868480553
- Cited by
- 70
- References
- 78
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 1
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA123368, CA123368)
- National Institute of General Medical Sciences (T32GM008169, GM105813, R01GM105813)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- Taiman, Yorkie, Hippo signaling pathway, ecdysone signaling, pathway crosstalk, transcriptional coactivation, Nanos, Piwi, tissue growth regulation
- MeSH terms
- YAP-Signaling Proteins, Hippo Kinases, Animals, Cells, Cultured, Drosophila melanogaster, Epithelium, Nuclear Proteins, Receptors, Steroid, RNA, Messenger, Transcription Factors, Transcription, Genetic, Wings, Animal, Trans-Activators, RNA-Binding Proteins, Protein Serine-Threonine Kinases, Gene Expression Regulation, Developmental, Stem Cell Factor, Drosophila Proteins, RNA Interference, RNA, Small Interfering, Intracellular Signaling Peptides and Proteins, Argonaute Proteins
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