The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
High-Resolution Expression Map of the Arabidopsis Root Reveals Alternative Splicing and lincRNA Regulation
Open accessAbstract
SUMMARY The extent to which alternative splicing and long intergenic noncoding RNAs (lincRNAs) contribute to the specialized functions of cells within an organ is poorly understood. We generated a comprehensive dataset of gene expression from individual cell types of the Arabidopsis root. Comparisons across cell types revealed that alternative splicing tends to remove parts of coding regions from a longer, major isoform, providing evidence for a progressive mechanism of splicing. Cell type-specific intron retention suggested a possible origin for this common form of alternative splicing. Coordinated alternative splicing across developmental stages pointed to a role in regulating differentiation. Consistent with this hypothesis, distinct isoforms of a transcription factor were shown to control developmental transitions. LincRNAs were generally lowly expressed at the level of individual cell types, but co-expression clusters provided clues as to their function. Our results highlight insights gained from analysis of expression at the level of individual cell types.
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Landscape of transcription in human cells
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Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
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The Evolutionary Landscape of Alternative Splicing in Vertebrate Species
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Cited by
Denyer, T., Ma, X., Klesen, S., Scacchi, E., Nieselt, K., & Timmermans, M. C. P. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.02.022 · Cited by 608
High-Throughput Single-Cell Transcriptome Profiling of Plant Cell Types
Shulse, C. N., Cole, B. J., Ciobanu, D., Lin, J., Yoshinaga, Y., Gouran, M., Turco, G. M., Zhu, Y., O’Malley, R. C., Brady, S. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.054 · Cited by 432
Shahan, R., Hsu, C.-W., Nolan, T. M., Cole, B. J., Taylor, I. W., Greenstreet, L., Zhang, S., Afanassiev, A., Vlot, A. H. C., Schiebinger, G., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.01.008 · Cited by 363
Self-citationRapid and Dynamic Alternative Splicing Impacts the Arabidopsis Cold Response Transcriptome
Calixto, C. P. G., Guo, W., James, A. B., Tzioutziou, N. A., Entizne, J. C., Panter, P. E., Knight, H., Nimmo, H. G., Zhang, R., & Brown, J. W. S. (2018) · The Plant Cell · doi:10.1105/tpc.18.00177 · Cited by 298
Metadata
- Authors
- Li, S., Yamada, M., Han, X., Ohler, U., & Benfey, P. N.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 39
- Issue
- 4
- Pages
- 508-522
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2554858735
- Cited by
- 311
- References
- 10
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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