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Redox Paradox: Can Hypoxia Heal Ischemic Hearts?
Open accessAbstract
Adult cardiomyocytes are largely thought to lack proliferative and therefore regenerative potential. Reporting in Nature, Nakada et al. (2016) find that a hypoxic regime reduces mitochondrial metabolism and promotes proliferation in adult mouse cardiomyocytes, resulting in increased regeneration following myocardial infarction. These findings suggest the potential to transform post-MI care.
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“Enhancing oxygen adaptation is beneficial following ischemic injury, such as stroke or myocardial infarction [16,17]”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [17]
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References 10 · Cited by 5
Research works printed but not linked: 10
- Guimarães-Camboa, 2015, Dev. Cell, 33, 507, 10.1016/j.devcel.2015.04.021 · DOI
- Hardziyenka, 2011, J. Am. Coll. Cardiol., 57, 921, 10.1016/j.jacc.2010.08.648 · DOI
- Hirai, 2016, Circ. Res., 118, 916, 10.1161/CIRCRESAHA.115.308101 · DOI
- Jopling, 2012, Circulation, 126, 3017, 10.1161/CIRCULATIONAHA.112.107888 · DOI
- Kimura, 2015, Nature, 523, 226, 10.1038/nature14582 · DOI
- Kobs, 2005, Am. J. Physiol. Heart Circ. Physiol., 288, H1209, 10.1152/ajpheart.01129.2003 · DOI
- Nakada, 2016, Nature
- Peacock, 1998, BMJ, 317, 1063, 10.1136/bmj.317.7165.1063 · DOI
- Puente, 2014, Cell, 157, 565, 10.1016/j.cell.2014.03.032 · DOI
- Soonpaa, 2013, Biochim. Biophys. Acta, 1833, 799, 10.1016/j.bbamcr.2012.10.029 · DOI
Metadata
- Authors
- Guimarães-Camboa, N., & Evans, S. M.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 39
- Issue
- 4
- Pages
- 392-394
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC5547440
- OpenAlex
- W2556234583
- Cited by
- 5
- References
- 10
- Citations by year
- 2026: 1 · 2024: 1 · 2020: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (DP1OD006428)
- National Heart, Lung, and Blood Institute (R01HL070867, DP1HL117649)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- hypoxia, cardiomyocyte proliferation, myocardial infarction, cardiac regeneration, mitochondrial metabolism, redox signaling, adult cardiomyocytes
- MeSH terms
- Animals, Hypoxia, Myocardial Infarction, Oxidation-Reduction, Regeneration, Myocytes, Cardiac, Mice
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- The paper
- Guimarães-Camboa, N., & Evans, S. M. (2016). Redox Paradox: Can Hypoxia Heal Ischemic Hearts? Developmental Cell. https://doi.org/10.1016/j.devcel.2016.11.007
