The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival
Open accessAbstract
SUMMARY Plants encounter a variety of stresses and must fine-tune their growth and stress-response programs to best suit their environment. BES1 functions as a master regulator in the brassinosteroid (BR) pathway that promotes plant growth. Here, we show that BES1 interacts with the ubiquitin receptor protein DSK2 and is targeted to the autophagy pathway during stress via the interaction of DSK2 with ATG8, a ubiquitin-like protein directing autophagosome formation and cargo recruitment. Additionally, DSK2 is phosphorylated by the GSK3-like kinase BIN2, a negative regulator in the BR pathway. BIN2 phosphorylation of DSK2 flanking its ATG8 interacting motifs (AIMs) promotes DSK2-ATG8 interaction, thereby targeting BES1 for degradation. Accordingly, loss-of-function dsk2 mutants accumulate BES1, have altered global gene expression profiles, and have compromised stress responses. Our results thus reveal that plants coordinate growth and stress responses by integrating BR and autophagy pathways and identify the molecular basis of this crosstalk.
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Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationBZR1 Mediates Brassinosteroid-Induced Autophagy and Nitrogen Starvation in Tomato
Wang, Y., Cao, J.-J., Wang, K.-X., Xia, X.-J., Shi, K., Zhou, Y.-H., Yu, J.-Q., & Zhou, J. (2019) · Plant Physiology · doi:10.1104/pp.18.01028 · Cited by 168
AlphaFold2 SLiM screen for LC3-LIR interactions in autophagy
Stuke, J. F. M., & Hummer, G. (2025) · Autophagy · doi:10.1080/15548627.2025.2493999 · Cited by 8
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Metadata
- Authors
- Nolan, T. M., Brennan, B., Yang, M., Chen, J., Zhang, M., Li, Z., Wang, X., Bassham, D. C., Walley, J., & Yin, Y.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 41
- Issue
- 1
- Pages
- 33-46.e7
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2606510453
- Cited by
- 339
- References
- 83
- FWCI
- 20.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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