Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency
Molotkov, Andrei, Mazot, Pierre, Brewer, J. Richard, Cinalli, Ryan M., Soriano, Philippe·2017·Developmental Cell
Cited by (190)
Items 101–190 of 190
- Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migrationFrancesco Antonica, Lorenzo Carlo Orietti, Richard L. Mort, Magdalena Zernicka‐Goetz · 2019 · Developmental Biology
- Transcriptional network governing extraembryonic endoderm cell fate choicePaula Duyen Pham, Hanbin Lu, Han Han, Jeff Jiajing Zhou, Aarushi Madan, Wenqi Wang, Cornelis Murre, Ken W.Y. Cho · 2023 · Developmental Biology
- A FGF2-mediated incoherent feedforward loop induces Erk inhibition and promotes naïve pluripotencyBorzo Gharibi, Emanuel Gonçalves, Buhe Nashun, Alex Montoya, Katherine Mankalow, Stephanie Strohbuecker, Rahuman S. Malik‐Sheriff, Alessandro Ciccarelli, Joana Carvalho, Emma L. Nye et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Suppression of ERK signalling promotes pluripotent epiblast in the human blastocystClaire S. Simon, Afshan McCarthy, Laura M. Woods, Desislava P. Staneva, Qiulin Huang, Madeleine Linneberg-Agerholm, Alex Faulkner, Athanasios Papathanasiou, Kay T. Elder, Phil Snell et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Pulling back the curtain: The hidden functions of receptor tyrosine kinases in developmentJames F. Clark, Philippe M. Soriano · 2022 · Current topics in developmental biology/Current Topics in Developmental Biology
- Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF SignallingXiao Hu, Yawen Tang, Wei Zhao, Juan Liu, Zhize Liu, Qianyin Yang, Meiqiang Chu, Jianhui Tian, Lei An, Shumin Wang · 2025 · Cell Proliferation
- Live imaging endogenous transcription factor dynamics reveals mechanisms of epiblast and primitive endoderm fate segregationRebecca Kim, David W. Denberg, Denis F. Faerberg, Hayden Nunley, Isabella Leite, Madeleine Chalifoux, Bradley W. Joyce, Jared E. Toettcher, Bin Gu, Eszter Pósfai · 2025 · Current Biology
- Specification and role of extraembryonic endoderm lineages in the periimplantation mouse embryoKatarzyna Filimonow, Roberto de la Fuente · 2021 · Theriogenology
- The functional diversity of the POUV-class proteins across vertebratesEvgeny I. Bakhmet, Alexey N. Tomilin · 2022 · Open Biology
- A Pancancer Analysis of the Expression Landscape and Clinical Relevance of Fibroblast Growth Factor Receptor 2 in Human CancersJuanni Li, Kuan Hu, Jinzhou Huang, Lei Zhou, Yuanliang Yan, Zhijie Xu · 2021 · Frontiers in Oncology
- A NANOG‐pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamicsHanuman T Kale, Rajendra Singh Rajpurohit, Debabrata Jana, Vijay V. Vishnu, Mansi Srivastava, Preeti R Mourya, G. Srinivas, P Chandra Shekar · 2022 · EMBO Reports
- Paracrine interactions through FGFR1 and FGFR2 receptors regulate the development of preimplantation mouse chimaeric embryoKatarzyna Krawczyk, Katarzyna Wilczak, Katarzyna Szczepańska, Marek Maleszewski, Aneta Suwińska · 2022 · Open Biology
- Influence of FGF4 and BMP4 on FGFR2 dynamics during the segregation of epiblast and primitive endoderm cells in the pre-implantation mouse embryoMarcelo Demarchi Goissis, Brian Bradshaw, Eszter Pósfai, Janet Rossant · 2023 · PLoS ONE
- Capturing and Interconverting Embryonic Cell Fates in a DishJennifer L. Watts, Alyson A. Lokken, Alexandra Moauro, Amy Ralston · 2018 · Current topics in developmental biology/Current Topics in Developmental Biology
- Emerging roles of transcriptional condensates as temporal signal integratorsKirstin Meyer, Bo Huang, Orion David Weiner · 2025 · Nature Reviews Genetics
- TimeTalk uses single-cell RNA-seq datasets to decipher cell-cell communication during early embryo developmentLongteng Wang, Zheng Yang, Yu Huining Sun, Shulin Mao, Hao Li, Xiaochen Bo, Cheng Li, Hebing Chen · 2023 · Communications Biology
- Transcriptional and epigenetic control of cell fate decisions in early embryosRamiro Alberio · 2017 · Reproduction Fertility and Development
- Etv5 safeguards trophoblast stem cells differentiation from mouse EPSCs by regulating fibroblast growth factor receptor 2Kui Zhu, Yuan Liu, Chen Fan, Mengyao Zhang, Hongxia Cao, Xin He, Na Li, Dianfeng Chu, Fang Li, Min Zou et al. · 2020 · Molecular Biology Reports
- Pluripotent stem cells in the research for extraembryonic cell differentiationYayoi Toyooka · 2021 · Development Growth & Differentiation
- Charting the emergent organotypic landscape of the mammalian gut endoderm at single-cell resolutionSonja Nowotschin, Manu N. Setty, Ying-Yi Kuo, Vincent Chi Hang Lui, Vidur Garg, Roshan Sharma, Claire S. Simon, Néstor Saiz, Rui Gardner, Stéphane C. Boutet et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- Cooperative genetic networks drive a mammalian cell state transitionAndreas Lackner, Robert Sehlke, Marius Garmhausen, Giuliano Giuseppe Stirparo, Michelle Huth, Fabian Titz-Teixeira, Petra van der Lelij, Julia Ramesmayer, Henry Fabian Thomas, Meryem Ralser et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Common modes of ERK induction resolve into context-specific signalling via emergent networks and cell-type-specific transcriptional repressionMarta Perera, Joshua M. Brickman · 2024 · Development
- ETV4 and ETV5 orchestrate FGF-mediated lineage specification and epiblast maturation during early mouse developmentClaire S. Simon, Woonyung Hur, Vidur Garg, Ying-Yi Kuo, Kathy K. Niakan, Anna‐Katerina Hadjantonakis · 2025 · Development
- Three-dimensional cell neighbourhood impacts differentiation in the inner mass cells of the mouse blastocystSabine Fischer, Elena Corujo-Simón, Joaquín Lilao‐Garzón, Ernst H. K. Stelzer, Silvia Muñoz Descalzo · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Diverse Fgfr1 signaling pathways and endocytic trafficking regulate early mesoderm developmentJames F. Clark, Philippe M. Soriano · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm developmentJames F. Clark, Philippe M. Soriano · 2024 · Genes & Development
- Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determinationParaskevi Athanasouli, Tijs Vanhessche, Frederic Lluı́s · 2025 · Life Science Alliance
- FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylationIlya A. Chuykin, Sergei Y. Sokol · 2025 · Nature Communications
- Timely stimulation of early embryo promotes the acquisition of pluripotencyFengying Zhang, Changmiao Pang, Haoyun Zhu, Yanglin Chen · 2022 · Cytometry Part A
- FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic developmentJames F. Clark, Philippe M. Soriano · 2023 · Biology Open
- Lineage-specific CDK activity dynamics characterize early mammalian developmentBechara Saykali, Andy D. Tran, James A. Cornwell, Matthew A. Caldwell, Paniz Rezvan Sangsari, Nicole Y. Morgan, Michael J. Kruhlak, Steven D. Cappell, Sergio Ruiz · 2025 · Cell Reports
- Multi-level Fgf4- and apoptosis-dependent regulatory mechanism ensures the plasticity of ESC-chimaeric mouse embryoAnna Soszyńska, Katarzyna Filimonow, Magdalena Wigger, Katarzyna Wołukanis, Alicja Gross, Katarzyna Szczepańska, Aneta Suwińska · 2023 · Development
- (De)constructing the blastocyst: Lessons in self-organization from the mouseBerenika Płusa, Anna‐Katerina Hadjantonakis · 2018 · Current Opinion in Systems Biology
- Transcriptional control by Sall4 in blastocysts facilitates lineage commitment of inner cell mass cellsAnzy Miller, Sarah Gharbi, Charles-Étienne Dumeau, Ryuichi Nishinakamura, Brian Hendrich · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Human naïve stem cell models reveal the role of FGF in hypoblast specification in the human embryoAnish Dattani, Elena Corujo-Simón, Arthur Radley, Tiam Heydari, Yasaman Taheriabkenar, Francesca A. Carlisle, Simeng Lin, Jonathan S. Mill, Peter W. Zandstra, Jennifer Nichols et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Wnt/β-catenin signalling modulates the timing of cell fate decision making in the early mouse embryoJoaquín Lilao‐Garzón, Elena Corujo-Simón, Meritxell Vinyoles, Sabine Fischer, José Ángel Guillén, Tina Balayo, Silvia Muñoz Descalzo · 2026 · PLoS ONE
- Boundary-guided cell alignment drives mouse epiblast maturationTakafumi Ichikawa, Pamela C. Guruciaga, Shuchang Hu, Steffen Plunder, Mei Makino, Marina Hamaji, Anniek Stokkermans, Shinjiro Yoshida, Takashi Hiiragi, Anna Erzberger · 2026 · Nature Physics
- Developmental Hurdles That Can Compromise Pregnancy during the First Month of Gestation in CattleSavannah L. Speckhart, Mary A. Oliver, Alan D. Ealy · 2023 · Animals
- Distinct requirements for the maintenance and establishment of mouse embryonic stem cellsRiyo Konishi, Toru Nakano, Shinpei Yamaguchi · 2018 · Stem Cell Research
- Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3Mónica Román-Trufero, Constance M Ito, Conrado Pedebos, Indiana Magdalou, Yi-Fang Wang, Mohammad Mahdi Karimi, Benjamin Moyon, Zoë Webster, Aida Di Gregorio, Véronique Azuara et al. · 2020 · Molecular Biology and Evolution
- Generation, characterization, and use of EKLF(Klf1)/CRE knock-in mice for cell-restricted analysesXue Li, Kaustav Mukherjee, Kevin A. Kelley, James J. Bieker · 2024 · Frontiers in Hematology
- Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse developmentXinjian Doris He, Louis F Taylor, Xiaosu Miao, Yingchao Shi, Xinhua Lin, Zhongzhou Yang, Xin Liu, Yi‐Liang Miao, Dominique Alfandari, Wei Cui et al. · 2024 · Biology of Reproduction
- Glycosylation in Stem Cell BiologyChika Ogura, Shoko Nishihara · 2025 · Handbook of experimental pharmacology
- FGF2 and BMP4 modulate lineage allocation in porcine parthenogenetic embryos cultured in N2B27 medium.Dong-Wook Kim, Kwang-Hwan Choi, Dong-Kyung Lee, Seokjong Lee, B. S. Choo, Jinsol Jeong, Y. Ahn, Jumi Kang, Chang-Kyu Lee · 2026 · Theriogenology
- HMGB1 regulates mitochondrial structure and reactive oxygen species balance during the transition from naïve to primed pluripotencyTatiana Yu. Starkova, Sergey V. Ponomartsev, Veniamin Fishman, Нариман Рашитович Баттулин, Nikolay Aksenov, Evgeny I. Bakhmet, Andrey A. Kuzmin, Dmitry S. Bogolyubov, Sergey A. Sinenko, Alexey N. Tomilin · 2026 · Frontiers in Cell and Developmental Biology
- Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editingDaniel Price, Grigory Zemlyanskiy, Watanya Trakarnphornsombat, Ignasi Forné, Nadezda Volkova, Louis Dubusse, Alexandra J Cooper, Axel Imhof, Aliaksandra Radzisheuskaya · 2026 · Nature Genetics
- Signaling Pathways in Human Blastocyst Development: From Molecular Mechanisms to In Vitro OptimizationYan Jiao, Jiapeng Liu, Congge Li, Yuexin Hu, Sanjun Zhao · 2025 · Journal of Developmental Biology
- Behind the developing brains and beating hearts of stem cell-derived embryo modelsGianluca Amadei, David Moore Glover · 2023 · Open Biology
- Generation of pulsatile ERK activity in mouse embryonic stem cells is regulated by Raf activityYayoi Toyooka, Kazuhiro Aoki, Fumiko Matsukawa Usami, Sanae Oka, Azusa Kato, Toshihiko Fujimori · 2023 · Scientific Reports
- ERK signalling orchestrates metachronous transition from naïve to formative pluripotencyCarla Mulas, Melanie Stammers, Siiri I. Salomaa, Constanze Heinzen, David M. Suter, Austin G Smith, Kevin J. Chalut · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- ETV4 and ETV5 Orchestrate FGF-Mediated Lineage Specification and Epiblast Maturation during Early Mouse DevelopmentClaire S. Simon, Vidur Garg, Ying-Yi Kuo, Kathy K. Niakan, Anna‐Katerina Hadjantonakis · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Investigating the dynamic signaling pathways involved in the specialization and differentiation of epiblast cells in early human embryosYong Wang, Lijing Wu, Meifeng Zheng, Jianhua Zhu, Lujuan Rong, Kaimin Yang, Xinyue Hu, Lifeng Xiang, Kui Duan · 2025 · Developmental Biology
- Lineage-specific enhancer insertions regulate Prdm14 to drive the rapid transition from naïve to formative pluripotency in rodentsKazumi Matsubara, Masaki Hirota, Kentaro Kajiwara, Hinako Senga, Shunsuke Matsui, Miyu Marutani, Yoshiyuki Seki · 2025 · Development
- Distinct roles for SETα and SETβ in early cell fate decisionsPatrick Siang Lin Lim, Eden Mishne, Malka Nissim‐Rafinia, Eran Meshorer · 2026 · Nucleic Acids Research
- Harnessing the murine inner cell mass mechanical environment enhances derivation of in vitro nascent primitive endoderm precursor cellsElena Corujo-Simón, Siiri I. Salomaa, Lawrence E. Bates, Ayaka Yanagida, William M. Mansfield, Hannes Becher, Jennifer Nichols, Kevin J. Chalut · 2026 · Development
- Transformation of Pluripotency States during Morphogenesis of Mouse and Human EpiblastVepa K. Abdyev, Е. В. Алпеева, E. N. Kalistratova, Ekaterina Andreevna Vorotelyak, A. V. Vasiliev · 2023 · Russian Journal of Developmental Biology
- ICM cells can be partitioned robustly through transient synchronization using secreted FGF4Xiaochan Xu, Ala Trusina, Kim Sneppen · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Deeply conserved super-enhancers maintain stem cell pluripotency in placental mammalsJuqing Zhang, Yaqi Zhou, Wei Yue, Zhenshuo Zhu, Xiaolong Wu, Shuai Yu, Qiaoyan Shen, Qin Pan, Wenjing Xu, Rui Zhang et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Pcbp1 constrains Oct4 expression in the context of pluripotencyEvgeny I. Bakhmet, Anna S. Zinovyeva, Andrey A. Kuzmin, D. V. Smirnova, Mikhail N. Gordeev, Eugeniy Petrenko, Nicolay D. Aksenov, Alexey N. Tomilin · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Lipid rafts increase to facilitate ectoderm lineage specification of differentiating embryonic stem cellsXu Chen, Bo Cao, Yingdong Huo, Gang Niu, Michael Q. Zhang, Zi-lin Mai, Xibin Lu, Hanben Niu, Dan-ni Chen, Yanxiang Ni · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Positive feedback loop of regulating ERK phosphorylation in mESCs mediated by Etv5-Tet2-Fgfr2 axisChen Fan, Kui Zhu, Yuan Liu, Mengyao Zhang, Hongxia Cao, Na Li, Yan Wang, Jinlian Hua, Huayan Wang, Shiqiang Zhang · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- The N-end rule pathway enzyme Naa10 supports epiblast specification in mouse embryonic stem cells by modulating FGF/MAPKDaisuke Takekoshi, Yoshimi Tokuzawa, Masahiro Sakanaka, Hidemasa Kato · 2019 · In Vitro Cellular & Developmental Biology - Animal
- Manipulating Embryonic Development and Endometrial Function in RuminantsSarah R. McCoski · 2018 · VTechWorks (Virginia Tech)
- Preimplantation Development: From Germ Cells to BlastocystBernard A.J. Roelen · 2020 · Learning materials in biosciences
- Adapting CRISPR/Cas9 Lentivirus Technology for Functional Studies of GATA6 & GATA4 during Bovine Preimplantation EmbryogenesisShicheng Ni · 2020
- FGF signaling in development beyond canonical pathwaysAyan T. Ray, Pierre Mazot, J. Richard Brewer, Catarina Catela, Colin J. Dinsmore, Philippe M. Soriano · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Deregulation of epigenetic marks is correlated to differential exon usage of developmental genesHoang Thu Trang, Siba Shanak, Ahmad Barghash, Volkhard Helms · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- A NANOG-pERK reciprocal regulatory circuit mediates Nanog autoregulation and ERK signaling dynamicsHanuman T Kale, Rajendra Singh Rajpurohit, Debabrata Jana, Vijay V. Vishnu, Mansi Srivastava, Preeti R Mourya, G. Srinivas, P Chandra Shekar · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Genesis of Epithelial Polarity in Early Mammalian EmbryosXu XX, Smith ER, Pedro J. I. Salas · 2021 · SCIREA journal of biology.
- Stem cell specific interferon stimulated gene expression is regulated by the formative pluripotency network through IRF1Merrit Romeike, Stephanie Spach, Marie L. Huber, Songjie Feng, Gintautas Vainorius, Ulrich Elling, Christa Buecker · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Avaliação funcional do gene NANOG na segregação de linhagens celulares em embriões bovinosLetícia Escobar Carreiro · 2022
- FGF2 and BMP4 influence on FGFR2 dynamics during the segregation of epiblast and primitive endoderm cells in the pre-implantation mouse embryoMarcelo Demarchi Goissis, Brian Bradshaw, Eszter Pósfai, Janet Rossant · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Analysis of the “Time Spent Outside” Hypothesis using Fluorescent Tracking of Ingressing CellsGeorgia Russell · 2023
- Genesis of Epithelial Polarity in Early Mammalian EmbryosXiang‐Xi Xu, Elizabeth R. Smith · 2023 · SCIREA journal of biology.
- Common modes of ERK induction resolve into context specific signalling via a combination of signal duration and cell type specific transcriptional repressionM. Perera, J. Brickman · 2024 · bioRxiv
- Transformation of Pluripotency States during Morphogenesis of Mouse and Human EpiblastVepa K. Abdyev, Е. В. Алпеева, E. N. Kalistratova, Ekaterina Andreevna Vorotelyak, A. V. Vasiliev · 2023 · Онтогенез
- Wnt/β-catenin signalling assists cell fate decision making in the early mouse embryoJoaquín Lilao‐Garzón, Elena Corujo-Simón, Meritxell Vinyoles, Sabine Fischer, José Ángel Guillén, Tina Balayo, Silvia Muñoz Descalzo · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Upregulation of the lncRNA XACT sustains pluripotency, blocks lineage specification, and drives germ cell tumor-like transcriptional programs in human pluripotent stem cellsKenji Izumi, Nami Motosugi, Akiko Sugiyama, Natsumi Kurosaki, Yumi Iida, Misaki Higashiseto, Keiko Yokoyama, Ayumi Sasaki, Atsushi Izumi, Tohru Kiumra et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- A conserved function of EZH2-PRC2 in repression of primitive endoderm fate in mouse and human pluripotent cellsJunyu Chen, Boyen Huang, Xuzhao Zhai, Zhe Xu, Shu Sun, Jie Hu, Xinyi Dai, Guokai Chen, Dan Liang, Lin Liu et al. · 2025 · Stem Cell Reports
- Effects of FGF2 and BMP4 on porcine embryo development and lineage specification in N2B27 mediumDong-Wook Kim, Kwang‐Hwan Choi, Dong‐Kyung Lee, Seokjong Lee, BeomSeok Choo, Jinsol Jeong, Yelim Ahn, Jumi Kang, Chang‐Kyu Lee · 2025 · SSRN Electronic Journal
- FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factorsLizhu Ma, Wei Fu, Lei An, Qianying Yang, Ruiqi Hai, Guangyin Xi, Yinjuan Wang, Juan Liu, Chao Zhang, Yao Fu et al. · 2026 · The EMBO Journal
- Caractérisation de la différenciation de l'endoderme primitif : Coopération entre la voie de signalisation RTK-FGF et le facteur de transcription Gata 6Stéphanie Hermitte · 2017
- Influence des voies de signalisation IGF et MAPK sur la spécification des lignages de l'embryon de souris préimplantatoireCécilia Bassalert · 2018
- The PI3K/AKT pathway regulates cell fate identities during early mouse developmentAnna Geiselmann · 2022
- Développement et morphogenèse de l'endoderme pariétal extra-embryonnaire de la souris : implication du facteur de transcription GATA6Ronan Quenec’Hdu · 2024
- The Role of Gp130 signaling in initiation of naïve Reprogramming of hPSCsTahereh Kiani · 2025
- Hsa-miR-92a-3p regulates cell-cycle and signaling programs during human extra-embryonic lineage commitmentPauliina Paloviita, Emilia Hautala, Rebecca Granskog, Sonja Nykänen, Roosa Pulkkanen, Ida Kirjanov, Reetta Santaniemi, Heli Grym, Christel Hydén‐Granskog, Timo Tuuri et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- The dynamic expression pattern of signaling pathways involved in early embryo developmentZifan Song, Shi Song, Nan Wang, Xiaomeng Wang, Liying Yan, Jie Qiao, P B Yuan · 2026 · Cell Communication and Signaling
- A primitive endoderm-centric view of mammalian developmentRebecca Kim, Denis F. Faerberg, Eszter Pósfai · 2026 · Development
- Emergence of the Endoderm in the Mammalian Embryo: From Cell Fate Specification to Gut Tube FormationSonja Nowotschin, Anna‐Katerina Hadjantonakis · 2026 · Annual Review of Cell and Developmental Biology