EGFR-Pak signaling selectively regulates glutamine deprivation-induced macropinocytosis

Lee, Szu-Wei, Zhang, Yijuan, Jung, Michael, Cruz, Nathalia, Alas, Basheer, Commisso, Cosimo·2019·Developmental Cell

Cited by (171)

Items 101–171 of 171

  1. Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment
    Jiarui Ma, Vipul Bhardwaj, Peter Edward Lobie, Vijay Pandey · 2026 · Molecular Cancer
  2. Amino acids suppress macropinocytosis and promote release of CSF1 receptor in macrophages
    Zachary I. Mendel, Mack B. Reynolds, Basel H. Abuaita, Mary X O’Riordan, Joel A. Swanson · 2022 · Journal of Cell Science
  3. Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma
    Ari Hashimoto, Haruka Handa, Soichiro Hata, Shigeru Hashimoto · 2022 · Frontiers in Oncology
  4. Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinoma
    Silvia Brambillasca, Maria Rosaria Cera, Adrian Andronache, Sumit Kumar Dey, Giovanni Fagà, Daniele Fancelli, Emanuela Frittoli, Maurizio Pasi, Michela Robusto, Mario Varasi et al. · 2024 · Biomedicine & Pharmacotherapy
  5. Melanophilin-induced primary cilia promote pancreatic cancer metastasis
    Yu‐Ying Chao, Ruei‐Ci Lin, Ping‐Jui Su, Chu-An Wang, Ting-Yuan Tu, Ya-Chin Hou, Yi-Tzui Tsai, I‐Chen Peng, Shaw‐Jenq Tsai, Yan‐Shen Shan et al. · 2025 · Cell Death and Disease
  6. Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis that Is Restrained by IGF1R and Promote Albumin–Drug Conjugate Response
    Huiyu Hu, Thomas S.C. Ng, Mikyung Kang, Ella Scott, Ran Li, Jeremy M. Quintana, Dylan Matvey, Venkata Rao Vantaku, Ralph Weissleder, Sareh Parangi et al. · 2023 · Clinical Cancer Research
  7. Oligopeptide transporter Slc15A modulates macropinocytosis in Dictyostelium by maintaining intracellular nutrient status
    Yiwei Zhang, Hui Tu, Yazhou Hao, Dong Li, Yihong Yang, Ye Yuan, Zhonglong Guo, Lei Li, Haibin Wang, Huaqing Cai · 2022 · Journal of Cell Science
  8. EGFR Pathway Links Amino Acid Levels and Induction of Macropinocytosis
    Vajira Weeresekara, Krushna Chandra Patra, Nabeel M. Bardeesy · 2019 · Developmental Cell
  9. The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress
    Pauline Pfänder, Lucas Hensen, Mirja Tamara Prentzell, Patricia Razquin Navas, Marie Solvay, Ahmed Sadik, Deepak Sayeeram, Ulrike Rehbein, Tobias Bausbacher, Anna-Sophia Egger et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  10. A hormetic response model for glutamine stress in cancer
    Shea F. Grenier, Cosimo Commisso · 2024 · Trends in cancer
  11. Corneal epithelial cells upregulate macropinocytosis to engulf metabolically active axonal mitochondria released by injured axons
    Sonali Pal‐Ghosh, Himani Datta Majumdar, Soneha Datta, Shelly Dimri, Jordan Hally, Hugo Wehmeyer, Zhong Chen, Mitchell A. Watsky, Jian‐xing Ma, Wentao Liang et al. · 2025 · The Ocular Surface
  12. Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells
    Tingyu Chen, Yiming Xu, Fan Yang, Yanxin Pan, Ning Ji, Jing Li, Xin Ying Zeng, Qianming Chen, Lu Jiang, Yingqiang Shen · 2025 · Cellular Signalling
  13. Unraveling stress-adaptation pathways in cancer: Functional dissection through CRISPR-based genetic screens
    Fatemeh Mokhles, Mohammad Amin Moosavi, Álvaro Gutiérrez-Uzquiza, Guillermo Velasco, Min Li, Marco Cordani · 2026 · Cancer Letters
  14. Rac1 and EGFR cooperate to activate Pak in response to nutrient stress
    Szu-Wei Lee, Cosimo Commisso · 2020 · Biochemical and Biophysical Research Communications
  15. Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux
    Maria I. Matias, Valérie Dardalhon, Naomi N. Taylor · 2020 · Molecular Cell
  16. Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes
    Koen M.O. Galenkamp, Cheska Marie Galapate, Yijuan Zhang, Cosimo Commisso · 2021 · Journal of Visualized Experiments
  17. Pancreatic cancer and adaptive metabolism in a nutrient-deficient environment
    Robert Słotwiński, Sylwia Małgorzata Słotwińska · 2021 · Central European Journal of Immunology
  18. Pancreatic cancer epigenetics: adaptive metabolism reprograms starving primary tumors for widespread metastatic outgrowth
    Arnaldo Franco, Jeffrey Duryea, Oliver Gene McDonald · 2023 · Cancer and Metastasis Reviews
  19. NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress
    Yi Xu, Michael H Nipper, Angel A. Dominguez, Chenhui He, Francis E. Sharkey, Sajid Khan, Han Xu, Daohong Zhou, Lei Zheng, Yu Luan et al. · 2026 · Journal of Clinical Investigation
  20. Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation
    Wanjun Lin, Zifeng Huang, Xuening Zhang, Dayuan Zheng, Yanchao Yang, Meina Shi, Dongfang Yang, Tong Chu, Wenzhe Ma · 2025 · Frontiers in Pharmacology
  21. Metabolic regulation of EGFR effector and feedback signaling in pancreatic cancer cells requires K-Ras
    Szu-Wei Lee, Cosimo Commisso · 2020 · Biochemical and Biophysical Research Communications
  22. Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer
    Yijuan Zhang, Ling Li, Swetha Maganti, Jennifer L. Hope, Cheska Marie Galapate, Florent Carrette, Karen Duong‐Polk, Anindya Bagchi, David A. Scott, Andrew M. Lowy et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Activation of TMEM16E scramblase induces ligand independent growth factor receptor signaling and macropinocytosis for membrane repair
    Jung-Eun Kim, Woori Ko, Siwoo Jin, Jin-Nyeong Woo, Yuna Jung, Inah Bae, Han Kyoung Choe, Daeha Seo, Bertil Hille, Byung‐Chang Suh · 2025 · Communications Biology
  24. Catabolic rewiring in cancer impacts dietary interventions
    Christos Chinopoulos · 2025 · Communications Biology
  25. Macropinocytosis: the Achilles’ heel of pancreatic cancer?
    Carl Andreasson, Daniel Ansari, Fredrik Ekbom, Roland E. Andersson · 2020 · Scandinavian Journal of Gastroenterology
  26. Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma
    Ying-Na Liao, Yan-Zhi Gai, Li-Heng Qian, Hong Pan, Yifan Zhang, Pin Li, Ying Guo, Shuxin Li, Hui Nie · 2024 · Oncogenesis
  27. ATP triggers macropinocytosis that internalizes and is regulated by PANX1
    Andrew K. J. Boyce, Emma van der Slagt, Juan C. Sanchez‐Arias, Leigh Anne Swayne · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  28. p53-armed oncolytic adenovirus induces apoptosis in pancreatic cancer-associated stellate cells via macropinocytosis
    Takeyoshi Nishiyama, Hiroshi Tazawa, Yasuo Nagai, Ryohei Shoji, Yoshinori Kajiwara, Naoyuki Hashimoto, Yosuke Takahashi, Satoru Kikuchi, Shinji Kuroda, Toshiaki Ohara et al. · 2025 · Cancer Gene Therapy
  29. Quantitation of macropinocytosis in glioblastoma based on high-content analysis
    Bo Wang, Xuan Yao, Qiang Dong, Xiaofang Wang, Hang Yin, Qiao Li, Xiaoqing Wang, Yang Liu, Yawen Pan, Guoqiang Yuan · 2023 · Journal of Neuroscience Methods
  30. Hepatocyte TM4SF5-mediated cytosolic NCOA3 stabilization and macropinocytosis support albumin uptake and bioenergetics for hepatocellular carcinoma progression
    Haesong Lee, Ji Eon Kim, Eun‐Ae Shin, Yangie Dwi Pinanga, Kyung‐hee Pyo, Eun Hae Lee, Wonsik Kim, Soyeon Kim, Chang-Sup Lim, Kyung Chul Yoon et al. · 2025 · Experimental & Molecular Medicine
  31. KRAS Addiction Promotes Cancer Cell Adaptation in Harsh Microenvironment Through Macropinocytosis
    Laetitia Seguin · 2022 · Sub-cellular biochemistry/Subcellular biochemistry
  32. Stopping the fat: Repurposing an antidepressant for cancer treatment
    Deepika Bhullar, Cosimo Commisso · 2023 · The Journal of Experimental Medicine
  33. The Noncanonical Functions of Metabolites in Tumor Progression
    Siyang Wu, Yijun Qi, Weiwei Yang · 2024 · Metabolites
  34. Catabolism of extracellular glutathione supplies amino acids to support tumor growth
    Fábio Hecht, Marco Zocchi, Emily T. Tuttle, Nathan P. Ward, Bradley Smith, Yun Pyo Kang, Juliana Cazarin, Zamira Guerra Soares, Mete Emir Özgürses, Huiping Zhao et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Oxidative stress and cancer metabolism: From pathogenesis to therapeutic opportunities
    Tejas Girish Agnihotri, Shyam Sudhakar Gomte, Biswajit Rout, Vasu Peddinti, Sandeep Kr Maharana, Devaraj Yallappa, Aakanchha Jain · 2025 · Elsevier eBooks
  36. NUFIP1 at the crossroads of ribophagy and disease: unveiling therapeutic implications
    Zhiyun Li, Yichen Bao, Xingpeng Yang, Yizhao Ma, Lin Qi, Xiaohui Du, Pengyue Zhao · 2025 · Journal of Translational Medicine
  37. [A Review of Metabolic Stress and Development of Pancreatic Cancer].
    Jintao Li, Mingzhu Lei, Qun‐Ying Lei, Miao Yin · 2021 · PubMed Central
  38. Targeting aberrant amino acid metabolism for pancreatic cancer therapy: Opportunities for nanoparticles
    Xinlong Zang, Ke Lei, Jia Wang, Ruining Gong, Chao Gao, Zhenghui Jing, Jinxiao Song, He Ren · 2024 · Chemical Engineering Journal
  39. Nutrient Levels and Nutrient Sources in Pancreatic Tumors
    Sven Groessl, Wilhelm Palm · 2024 · Cancer Research
  40. A role for class I p21-activated kinases in the regulation of the excitability of the actin cytoskeleton
    Joe J. Tyler, Anthony C. Davidson, Megan E. Poxon, Montserrat Llanses, Peter J. Hume, Jason King, Vassilis E. Koronakis · 2025 · Journal of Cell Science
  41. The expression of congenital Shoc2 variants induces AKT-dependent crosstalk activation of the ERK1/2 pathway
    Patricia G. Wilson, Lina G. Abdelmoti, Tianyan Gao, Emilia Galperin · 2024 · Human Molecular Genetics
  42. ATP increases murine neuroblastoma cell size through a PANX1- and macropinocytosis-dependent mechanism
    Andrew K. J. Boyce, Emma van der Slagt, Leigh E. Wicki‐Stordeur, Leigh Anne Swayne · 2025 · Biology Open
  43. Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer
    Zecheng Yang, Madelaine Skolastika Theardy, Shuaitong Chen, Yongkun Wei, Mitsunobu Takeda, Yue Zeng, Xiaofei Wang, Jun Yao, Jennifer Li, Prapassorn Thirasastr et al. · 2026 · Cell Reports Medicine
  44. Dual targeting of SLC6A14 and autophagy/macropinocytosis enhances therapeutic efficacy in pancreatic ductal adenocarcinoma
    Mosharaf Mahmud Syed, Devaraja Rajasekaran, Souad R. Sennoune, Tanima Sharker, Oscar Sanchez, Mary Katherine Jurek, Longfa Kou, Ruijie Chen, Vadivel Ganapathy, Yangzom D. Bhutia · 2026 · Biochemical Journal
  45. Macropinocytosis inhibition attenuates profibrotic responses in lung fibroblasts and pulmonary fibrosis models
    Iván O. Rosas, Aaron K McDowell-Sanchez, Santiago Sanchez, Juan Cala-García, Alan R. Waich Cohen, Elisa Ruiz-Echartea, Scott A. Ochsner, Daniel C. Kraushaar, Lindsay J. Celada, Dandan Sun et al. · 2026 · Journal of Clinical Investigation
  46. Insights into the molecular regulatory mechanisms of tumor macropinocytosis
    Chunlan Wang, Zihang Yuan, Bo Lin, Ziru Meng, Zhe Jin, Fei Yang, Hua Su · 2025 · Chinese Science Bulletin (Chinese Version)
  47. Measuring the pH, Redox Chemistries, and Degradative Capacity of Macropinosomes using Dual-Fluorophore Ratiometric Microscopy
    Liam Wilkinson, Johnathan Canton · 2021 · Journal of Visualized Experiments
  48. GAS6-AXL signaling triggers actin remodeling and macropinocytosis that drive cancer cell invasion
    Daria Zdżalik-Bielecka, Agata Poświata, Kamila Kozik, Kamil Jastrzębski, Kay Oliver Schink, Marta Brewińska‐Olchowik, Katarzyna Piwocka, Harald Stenmark, Marta Miączyńska · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Supraphysiological glutamine as a means of depleting intracellular amino acids to enhance pancreatic cancer chemosensitivity
    Hayato Muranaka, Sandrine Billet, Carlos Cruz‐Hernández, Johanna ten Hoeve, Gabrielle Gonzales, Omer Hany Miligy Elmadbouh, Le Zhang, Bethany Smith, Mourad Tighiouart, Sungyong You et al. · 2023 · Research Square
  50. Distinct sensing of BCAAs by mTOR and c-Myc governs T cell proliferation, independent of catabolism
    Kelly Rome, Elise Hall, Tran Ngoc Van Le, Alison Jaccard, Aaron Wu, Nathaniel W. Snyder, Kathryn E. Wellen, Will Bailis · 2026 · EMBO Reports
  51. Glutamine synthetase : a potential therapeutic target in acute myeloid leukemia
    Johanna Kreitz · 2022
  52. Macropinocytosis
    Joel A. Swanson · 2022 · Elsevier eBooks
  53. Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination
    Yi-Chang Wang, Andrew A. Kelso, Adak Karamafrooz, Yi‐Hsuan Chen, Wei‐Kai Chen, Chun-Ting Cheng, Yue Qi, Long Gu, Linda H. Malkas, Hsing‐Jien Kung et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  54. The expression of congenital Shoc2 variants induces AKT-dependent feedback activation of the ERK1/2 pathway
    Patricia G. Wilson, Lina G. Abdelmoti, Tianyan Gao, Emilia Galperin · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  55. PLPP2 as a metabolic and immune marker for predicting survival and enhancing response to anti-PD1 therapy in pancreatic cancer
    Guannan Sheng, Xiaoyan Du, Bo Ni, Ziyun Liu, Chenyan Wu, Kewei Meng, Yongjie Xie, Tao Yang · 2024 · Research Square
  56. A role for class I PAKs in the regulation of the excitability of the actin cytoskeleton
    Joe J. Tyler, Anthony C. Davidson, Megan E. Poxon, Montserrat Llanses, Pete Hume, Jason King, Vassilis E. Koronakis · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
    Marianna Hellén, Isabelle Weert, Stephan A. Müller, Šárka Lehtonen, Michael Peitz, Klaus Fließbach, Mari Takalo, Marja Koskuvi, Stefan F. Lichtenthaler, Ville Leinonen et al. · 2025 · Research Square
  58. Macropinocytosis inhibition attenuates pro-fibrotic responses in lung fibroblasts and pulmonary fibrosis
    Iván O. Rosas, Aaron K McDowell-Sanchez, Santiago Sanchez, Juan Cala-García, Alan R. Waich Cohen, Maria Elisa Ruiz Echartea, Scott A. Ochsner, Daniel C. Kraushaar, Lindsay J. Celada, Dandan Sun et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  59. LncRNA AFAP1-AS1 promoting residual tumor progression after insufficient radiofrequency ablation by up-regulating macropinocytosis in hepatocellular carcinoma
    Qiuxia Wei, Shiyu Xiong, Wanrong Luo, Qi Zhang, Sui Zheng, Man Luo, Haifeng Tang, Wenyue Zhang, Baoming Luo · 2025 · Cellular Signalling
  60. PP2A activation drives aberrant macropinocytosis and cell death in pancreatic ductal adenocarcinoma
    Garima Baral, Claire M. Pfeffer, Sara N. Filippelli, Indiraa Doraivel, Brittany N. Heil, Lauren E. Gartenhaus, Kasi Hansen, Joy Wu, Goutham Narla, Emma H. Doud et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  61. Macropinocytosis enables metabolic recycling of extracellular DNA in cancer cells
    Wen‐Hsuan Yang, Olivia T. Stamatatos, Evdokia Michalopoulou, Ava Sann, Paolo Cifani, Linda Van Aelst, Justin R. Cross, Tse-Luen Wee, Michael J. Lukey · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  62. SG33, a Vaccine Strain of Myxoma Virus with Oncolytic Potential, Exploits Macropinocytosis and Clathrin-Mediated Endocytosis for Entry into Pancreatic Cancer Cells
    Nikolaos Kontopoulos, Noémie Delenclos, Lætitia Ligat, Sokunthea Top, Franck Gallardo, Stéphane Bertagnoli, Nelson Dusetti, Louis Buscail, Pierre Cordelier · 2026 · Human Gene Therapy
  63. The interplay between p21-activated kinases and tumour-infiltrating dendritic cells and T cells and its implication in pancreatic cancer immunotherapy
    Rui Jian, Yi Ma, Mehrdad Nikfarjam, Hong He · 2026 · Cell Communication and Signaling
  64. Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology
    Mao Li, Canhua Huang, Shuguang Yu · 2026 · Genes & Diseases
  65. Macropinocytosis: A central orchestrator in tumor development and therapeutic resistance
    Chuxiang Wang, Xin Wang, Ziyi Jiang, Junyi Zhao, Xiaobing Wang, Yutao Liu, Junhu Yuan, Yuchen Jiao · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  66. Beyond the scaffold: extracellular matrix uptake in breast cancer
    Elena Rainero · 2026 · Biochemical Society Transactions
  67. Glutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1 mediated metabolic reprogramming
    Jiatong Li, Ao Gu, Ziheng Jia, Mengyao Li, Jinlu Zuo, Ziyi Wang, Xuechuan Li, Jiayi Feng, Tong Xue, Shuyang Zhai et al. · 2026 · Cell Reports Medicine
  68. Unraveling the role of glutamine metabolism in cancer: from cell death mechanisms to tumor microenvironment modulation
    Xintong Peng, Shuang Liu, Yongguang Tao · 2026 · Experimental Hematology and Oncology
  69. Autophagy inhibition in pancreatic cancer: hope or hype?
    Emma Guilbaud, Edna Cukierman, Igor A. Astsaturov, Lorenzo Galluzzi · 2026 · Autophagy Reports
  70. Single-cell landscape reveals PLPP2 upregulation underlying radiotherapy resistance and immune microenvironment remodeling in pancreatic cancer
    Yifei Wang, Parhat Kaysar, Yijian Ma, Ziyun Liu, Yuxi Han, Weishuai Liu, Huifang Pang, Yaoyao Zhou · 2026 · Translational Oncology
  71. Glutamine deprivation elevates EFNB3 and its potential link to macropinocytosis in glioblastoma
    Bo Wang, Xuan Yao, Yuanping Su, Guo-QiangYuan, YaWen Pan · 2026 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease