Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family
Open accessAbstract
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics to migrate to other locations and acquire new properties. Epithelial plasticity responses are directed through cooperation of signaling pathways, with TGF-β and TGF-β-related proteins playing prominent instructive roles. Epithelial-mesenchymal transitions (EMTs) directed by activin-like molecules, bone morphogenetic proteins, or TGF-β regulate metazoan development and wound healing and drive fibrosis and cancer progression. In carcinomas, diverse EMTs enable stem cell generation, anti-cancer drug resistance, genomic instability, and localized immunosuppression. This review discusses roles of TGF-β and TGF-β-related proteins, and underlying molecular mechanisms, in epithelial plasticity in development and wound healing, fibrosis, and cancer.
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TGFβ signalling has previously been shown to be an important regulator of epithelial cell plasticity and migration.
“which has previously been shown to be an important regulator of epithelial cell plasticity and migration20”
From Multimodal decoding of human liver regeneration (2024) · cites this paper as [20]
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References 228 · Cited by 187
- Authors
- Katsuno, Y., & Derynck, R.
- Affiliations
- The University of Tokyo (JP)
- University of California, San Francisco (US)
- Corresponding author
- Derynck, Rik
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 56
- Issue
- 6
- Pages
- 726-746
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W3137803078
- Cited by
- 187
- References
- 228
- Citations by year
- 2026: 37 · 2025: 35 · 2024: 41 · 2023: 30 · 2022: 31 · 2021: 12 · 2020: 1
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 386 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (20K07562)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- epithelial plasticity, epithelial-mesenchymal transition, TGF-beta superfamily, bone morphogenetic proteins, metazoan development, wound healing, fibrosis, tumor progression, carcinoma, cancer stem cells, drug resistance, genomic instability, immunosuppression
- MeSH terms
- Animals, Epithelial Cells, Humans, Neoplasms, Transforming Growth Factor beta, Epithelial-Mesenchymal Transition
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