Distributed and centralized control during differentiation
Open accessAbstract
A persistent view of cell fate choices during development entails centralized control by so-called master regulators. A recent single-cell study of the large-scale fate specification during mammalian gastrulation (Mittnenzweig et al., 2021) implies the prevalence of more distributed forms of control.
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Cell fate choice involves a more distributed form of control relying on combinatorial activities of dozens of TFs rather than an organization strictly dominated by a few master TFs.
“recent insights into the understanding of cell fate choice, which have suggested a more distributed form of control relying on combinatorial activities of dozens of TFs rather than an organization strictly dominated by a few master TFs (Chubb et al, 2021; Mittnenzweig et al, 2021).”
From An extended transcription factor regulatory network controls hepatocyte identity (2023) · cites this paper as Chubb et al, 2021
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References 9 · Cited by 4
- Authors
- Chubb, J. R., Ford, H. Z., & Antolović, V.
- Affiliations
- MRC Laboratory for Molecular Cell Biology (GB)
- Corresponding author
- Chubb, Jonathan R.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 56
- Issue
- 15
- Pages
- 2142-2144
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W3187781975
- Cited by
- 4
- References
- 9
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 373 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- cell fate specification, master regulators, centralized control, distributed control, single-cell transcriptomics, developmental gene regulation
- MeSH terms
- Animals, Cell Differentiation, Gastrulation
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