Condensates control the actin cytoskeleton
Abstract
The formation of actin filament networks with specific architectures is essential for diverse cellular processes. In this issue of Developmental Cell, Walker et al. demonstrate that biomolecular condensates containing F-actin binding proteins have an inherent capacity to assemble and bundle actin filaments, despite the proteins lacking polymerase or bundling activities.
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Many proteins involved in actin cytoskeletal dynamics undergo LLPS to concentrate effectors and facilitate signal transduction.
“Notably, many proteins involved in actin cytoskeletal dynamics undergo LLPS to concentrate effectors and facilitate signal transduction. 26”
From Aberrant phase separation from a rare <i>ABI3</i> mutation drives microglial dysfunction and Alzheimer's risk (2026) · cites this paper as [26]
Phase separation regulates the cytoskeleton, which is closely linked to cell migration.
“Because phase separation has been reported to regulate the cytoskeleton, 26 which is closely linked to cell migration”
From Aberrant phase separation from a rare <i>ABI3</i> mutation drives microglial dysfunction and Alzheimer's risk (2026) · cites this paper as [26]
LLPS plays key roles in fundamental biological processes such as cytoskeletal regulation, synaptic signaling, and stress granule formation.
“In addition, LLPS plays key roles in fundamental biological processes such as cytoskeletal regulation, 26 synaptic signaling, 49 and stress granule formation. 50 , 51”
From Aberrant phase separation from a rare <i>ABI3</i> mutation drives microglial dysfunction and Alzheimer's risk (2026) · cites this paper as [26]
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Li, S., Lu, J., Zeng, K., Lu, X., Zhang, J., Feng, S., Liang, C., Cai, Y., Yao, S., Huang, Q., et al. (2026) · Alzheimer's & Dementia · doi:10.1002/alz.71812
- Authors
- Cheng, X., & Case, L. B.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Case, Lindsay B.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2025-06
- Volume
- 60
- Issue
- 11
- Pages
- 1519-1520
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W4411135080
- Cited by
- 2
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association Inc
- Air Force Office of Scientific Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- biomolecular condensates, actin cytoskeleton, actin bundling, F-actin binding protein, actin filament assembly, liquid-liquid phase separation
- MeSH terms
- Biomolecular Condensates, Actins, Animals, Humans, Microfilament Proteins, Actin Cytoskeleton
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