A low-grade increase of serum pancreatic exocrine enzyme levels by dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes
Abstract
A potential adverse effect of dipeptidyl peptidase-4 inhibitors (DPP-4i) on the pancreas remains controversial. We evaluated the DPP-4i effects on pancreatic amylase and lipase activity in patients with type 2 diabetes. These enzymes were slightly but significantly increased, suggesting DPP-4i cause a low-grade inflammatory change in the exocrine pancreas.
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One consistent finding is a subtle and asymptomatic increase in plasma lipase and amylase level, which occurs within hours of administration.
“One consistent finding is a subtle and asymptomatic increase in plasma lipase and amylase level (64, 65), which occurs within hours of administration (66).”
From Safety of Semaglutide (2021) · cites this paper as [65]
Cites
Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits
Drucker, D. J., Sherman, S. I., Gorelick, F. S., Bergenstal, R. M., Sherwin, R. S., & Buse, J. B. (2010) · Diabetes Care · doi:10.2337/dc09-1499 · Cited by 316 · see citing works
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Smits, M. M., & Van Raalte, D. H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.645563 · Cited by 332 · see citing works
Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls
Drucker, D. J. (2013) · Diabetes · doi:10.2337/db13-0822 · Cited by 272 · see citing works
Nauck, M., Rizzo, M., Johnson, A., Bosch-Traberg, H., Madsen, J., & Cariou, B. (2016) · Diabetes Care · doi:10.2337/dc15-2479 · Cited by 143 · see citing works
- Authors
- Tokuyama, H., Kawamura, H., Fujimoto, M., Kobayashi, K., Nieda, M., Okazawa, T., Takemoto, M., & Shimada, F.
- Affiliations
- Chiba University (JP)
- Biotherapy Institute of Japan (JP)
- National Hospital Organization Chiba Medical Center (JP)
- Corresponding author
- Tokuyama, Hirotake
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 100
- Issue
- 3
- Pages
- e66-e69
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W1994258642
- Cited by
- 24
- References
- 1
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 2
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23591297, 24591312)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
- Keywords
- DPP-4 inhibitors, type 2 diabetes, pancreatic exocrine function, serum amylase, serum lipase, adverse drug reactions, pancreatitis, drug safety
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Female, Humans, Lipase, Male, Middle Aged, Pancreas, Pancreatitis, Retrospective Studies, Dipeptidyl-Peptidase IV Inhibitors, Pancreatic alpha-Amylases
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