Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes
Abstract
We analyzed circulating Meteorin-like (METRNL) levels in human. Serum METRNL levels were significantly lower in subjects with diabetes mellitus compared with those without diabetes. Serum METRNL was negatively correlated with the serum glucose level and insulin resistance. Metformin treatment did not increase the serum METRL levels after 12 weeks.
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Serum Metrnl levels are decreased in patients with T2D and inversely correlate with fasting glucose levels.
“However, serum Metrnl levels are decreased in patients with T2D and inversely correlate with fasting glucose levels 137.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [137]
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References 10 · Cited by 75
- Authors
- Lee, J. H., Kang, Y. E., Kim, J. M., Choung, S., Joung, K. H., Kim, H. J., & Ku, B. J.
- Affiliations
- Chungnam National University (KR)
- Corresponding author
- Ku, Bon Jeong
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 135
- Pages
- 7-10
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W2767126254
- Cited by
- 75
- References
- 10
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 12 · 2022: 8 · 2021: 5 · 2020: 13 · 2019: 8 · 2018: 4
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korean Government (NRF-2016R1D1A1A09916900, NRF-2017R1A1A1A05001474, NRF-2014R1A1A3053786)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- meteorin-like protein, Metrnl, type 2 diabetes, serum biomarkers, insulin resistance, serum glucose, metformin, newly diagnosed diabetes
- MeSH terms
- Diabetes Mellitus, Type 2, Female, Humans, Insulin, Insulin Resistance, Male, Metformin, Middle Aged, Nerve Tissue Proteins, Intercellular Signaling Peptides and Proteins
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