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Injecting drug use and community-associated methicillin-resistant Staphylococcus aureus infection
Abstract
To demonstrate that injecting drug use is a major risk factor of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection and injecting drug users may be a reservoir of CA-MRSA infection in our community, we conducted a matched case-control study. Cases were CA-MRSA-infected patients at University of California, Davis, Medical Center, Sacramento, CA, from December 1, 2003, to May 31, 2004. Two control groups were community-associated methicillin-susceptible S. aureus (CA-MSSA)-infected patients and a randomly selected uninfected patient group in the same hospital. Controls were matched to cases by age and isolate culture date. One hundred twenty-seven CA-MSSA patients and 381 randomly selected uninfected controls were selected to match the 127 CA-MRSA cases. The adjusted odds ratio of injecting drug use compared with the CA-MSSA group was 2.11 (95% confidence interval [CI], 1.1-4.3) and 4.09 (95% CI, 2.2-7.5) compared with the uninfected group. We suggest that injecting drug use is a significant risk factor for CA-MRSA infection, which could contribute to the increasing prevalence of CA-MRSA in an urban community.
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Individuals who inject illicit drugs are more likely to be positive for CA-MRSA.
“Individuals who inject illicit drugs are more likely to be positive for CA-MRSA [2, 3, 8, 9].”
From Community-associated methicillin-resistant Staphylococcus aureus is prevalent in wounds of community-based injection drug users (2010) · cites this paper as [8]
S. aureus was the most prevalent microbe found in wounds.
“Consistent with the literature, S. aureus was the most prevalent microbe found in wounds [2, 8, 20].”
From Community-associated methicillin-resistant Staphylococcus aureus is prevalent in wounds of community-based injection drug users (2010) · cites this paper as [8]
Injection drug use has been associated as a broad risk factor for CA-MRSA infection.
“Injection drug use has been associated as a broad risk factor for CA-MRSA infection [8].”
From Community-associated methicillin-resistant Staphylococcus aureus is prevalent in wounds of community-based injection drug users (2010) · cites this paper as [8]
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References 21 · Cited by 32
Research works printed but not linked: 16
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Metadata
- Authors
- Huang, H., Cohen, S. H., King, J. H., Monchaud, C., Nguyen, H., & Flynn, N. M.
- Affiliations
- University of California Davis Medical Center (US)
- Corresponding author
- Flynn, Neil M.
- Venue
- Diagnostic Microbiology and Infectious Disease
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 60
- Issue
- 4
- Pages
- 347-350
- ISSN
- 0732-8893 (ISSN-L)
- OpenAlex
- W2041509233
- Cited by
- 32
- References
- 21
- Citations by year
- 2025: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2012: 5
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diagnostic Microbiology and Infectious Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Keywords
- intravenous drug use, community-associated methicillin-resistant Staphylococcus aureus, risk factors, reservoir of infection, urban communities, nosocomial infections, methicillin resistance
- MeSH terms
- Adult, California, Female, Humans, Male, Middle Aged, Risk Factors, Staphylococcal Infections, Staphylococcus aureus, Substance Abuse, Intravenous, Case-Control Studies, Methicillin Resistance, Community-Acquired Infections
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