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Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes
Open accessAbstract
The emergence of carbapenem resistance in Enterobacteriaceae is an important threat to global health. Reported outcomes of infections with carbapenem-resistant Enterobacteriaceae (CRE) are poor. Very few options remain for the treatment of these virulent organisms. Antibiotics which are currently in use to treat CRE infections include aminoglycosides, polymyxins, tigecycline, fosfomycin, and temocillin. In addition, the role of combination therapy, including carbapenem containing regimens, remains to be defined. There are several important concerns regarding all of these treatment options such as limited efficacy, increasing reports of resistance, and specific toxicities. Data from retrospective studies favor combination therapy over single-agent therapy for the treatment of CRE bloodstream infections. In summary, new antibiotics are greatly needed, as is additional prospective research.
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Cited by
Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria
Nordmann, P., & Poirel, L. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz824 · Cited by 721
van Duin, D., & Bonomo, R. A. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw243 · Cited by 549
Self-citationCassotta, A., Goldstein, J. D., Durini, G., Jarrossay, D., Baggi Menozzi, F., Venditti, M., Russo, A., Falcone, M., Lanzavecchia, A., Gagliardi, M. C., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202048630 · Cited by 23
Metadata
- Authors
- van Duin, D., Kaye, K. S., Neuner, E. A., & Bonomo, R. A.
- Venue
- Diagnostic Microbiology and Infectious Disease
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 75
- Issue
- 2
- Pages
- 115-120
- ISSN
- 0732-8893 (ISSN-L)
- OpenAlex
- W2021439166
- Cited by
- 352
- References
- 0
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- green
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- van Duin, D., Kaye, K. S., Neuner, E. A., & Bonomo, R. A. (2013). Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes. Diagnostic Microbiology and Infectious Disease. https://doi.org/10.1016/j.diagmicrobio.2012.11.009
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